Abstract:
PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delivery such as ritonavir 'boosting' of HIV-protease inhibitors have led to a perception of improvements in the tolerability and durability of contemporary cART regimens. It is in turn assumed that these developments have led to improved outcomes in the latter era of cART. RECENT FINDINGS:Both cohort studies and randomized clinical trials suggest improvements in cART outcomes over calendar time. Key associated factors include reduced pill burden and dosing interval and improved tolerability and reduced toxicity of newer ART. A critical appreciation of the association between ART adherence and regimen durability has been important. Cohorts in recent times have included more patients who are completely ART-naïve at therapy initiation. SUMMARY:The prognosis of HIV infection in developed countries is in the order of 40 years after cART initiation. An appreciation of the factors associated with long-term control of HIV viraemia is essential for the optimal management of the HIV-infected individual in contemporary practice.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Boyd MAdoi
10.1097/COH.0b013e328329fc8dsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
194-9issue
3eissn
1746-630Xissn
1746-6318pii
01222929-200905000-00008journal_volume
4pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. RECENT FINDINGS:DTG has been teste...
journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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更新日期:2011-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282fbaaba
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...
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更新日期:2020-03-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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更新日期:2010-03-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00