HIV, alcohol, and noninjection drug use.

abstract：PURPOSE OF REVIEW:To describe the causes, evaluation, and management of early virological failure in patients treated with their first antiretroviral regimen. RECENT FINDINGS:Combination antiretroviral therapy predictably induces a rapid virological response, with the majority of patients achieving an undetectable HIV...

journal_title：Current opinion in HIV and AIDS

authors： Sax PE

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...

journal_title：Current opinion in HIV and AIDS

authors： Secor WE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...

journal_title：Current opinion in HIV and AIDS

authors： Alvarez E,Belloso WH,Boyd MA,Inkaya AÇ,Hsieh E,Kambugu A,Kaminski G,Martinez E,Stellbrink HJ,Walmsley S,Brown TT,Mallon PW

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV functional cure requires the elimination or a major reduction of HIV reservoir pool including male and female genital HIV reservoirs. A comprehensive understanding of HIV dynamics in these compartments is mandatory. RECENT FINDINGS:Data from chronically HIV-infected therapy-naïve individuals or f...

journal_title：Current opinion in HIV and AIDS

authors： Gantner P,Ghosn J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...

journal_title：Current opinion in HIV and AIDS

authors： la Porte C

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review current data on HIV-1 resistance arising from the use of fixed dose combination tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for preexposure prophylaxis (PrEP) to prevent HIV-1 infection. RECENT FINDINGS:Resistance to tenofovir (TNV) or FTC is infrequently selected by TDF/FTC PrEP ...

journal_title：Current opinion in HIV and AIDS

authors： Parikh UM,Mellors JW

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...

journal_title：Current opinion in HIV and AIDS

authors： Lori F,Foli A,Lisziewicz J

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to describe progress in research and development of vaccines to prevent HIV/AIDS, emphasizing clinical trials and human studies published during the past year. RECENT FINDINGS:Clinical trial design depends, in large part, on whether vaccines are expected to provide protecti...

journal_title：Current opinion in HIV and AIDS

authors： Fast PE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

journal_title：Current opinion in HIV and AIDS

authors： Sabin KM,Johnston LG

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...

journal_title：Current opinion in HIV and AIDS

authors： Andersen-Nissen E,Heit A,McElrath MJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...

journal_title：Current opinion in HIV and AIDS

authors： Rueda S,Law S,Rourke SB

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:It has been demonstrated that extensive virus diversification and antibody coevolution are necessary to give rise to broadly neutralizing antibodies targeting the envelope protein of HIV-1. Here, we discuss recent progress of vaccine design approaches aiming on strategies to initiate and guide B-cell ...

journal_title：Current opinion in HIV and AIDS

authors： Peterhoff D,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. RECENT FINDINGS:Most studies show that HIV-infected adults hav...

journal_title：Current opinion in HIV and AIDS

authors： Koay WLA,Siems LV,Persaud D

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

journal_title：Current opinion in HIV and AIDS

authors： Orsi F,d'almeida C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...

journal_title：Current opinion in HIV and AIDS

authors： Duerr A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is bein...

journal_title：Current opinion in HIV and AIDS

authors： Jackson A,McGowan I

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...

journal_title：Current opinion in HIV and AIDS

authors： Nachega JB,Mills EJ,Schechter M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...

journal_title：Current opinion in HIV and AIDS

authors： Scully EP

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The interaction between fall and fracture risk factors is an area of increasing clinical relevance, but little information is known about the age-specific issues in bone health unique to HIV-infected adults. The present review will focus on what is known about falls and fall risk factors among HIV-inf...

journal_title：Current opinion in HIV and AIDS

authors： Erlandson KM,Guaraldi G,Falutz J

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...

journal_title：Current opinion in HIV and AIDS

authors： Davies MA,Gibb D,Turkova A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and ho...

journal_title：Current opinion in HIV and AIDS

authors： Cubas R,Perreau M

更新日期：2014-09-01 00:00:00