Profiling immunity to HIV vaccines with systems biology.

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...

journal_title：Current opinion in HIV and AIDS

authors： Sereti I,Rodger AJ,French MA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...

journal_title：Current opinion in HIV and AIDS

authors： Alvarez E,Belloso WH,Boyd MA,Inkaya AÇ,Hsieh E,Kambugu A,Kaminski G,Martinez E,Stellbrink HJ,Walmsley S,Brown TT,Mallon PW

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to describe progress in research and development of vaccines to prevent HIV/AIDS, emphasizing clinical trials and human studies published during the past year. RECENT FINDINGS:Clinical trial design depends, in large part, on whether vaccines are expected to provide protecti...

journal_title：Current opinion in HIV and AIDS

authors： Fast PE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity ...

journal_title：Current opinion in HIV and AIDS

authors： Margolis DM

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Highly active antiretroviral therapy has markedly reduced HIV morbidity and mortality in industrialized countries. Expanded access to the 6.5 million individuals in immediate need of antiretroviral therapy using a public-health-systems approach is now promulgated as an international policy. An approxi...

journal_title：Current opinion in HIV and AIDS

authors： Bekker LG,Egger M,Wood R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...

journal_title：Current opinion in HIV and AIDS

authors： Duerr A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

journal_title：Current opinion in HIV and AIDS

authors： Mayne ES,George JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to ef...

journal_title：Current opinion in HIV and AIDS

authors： Asbach B,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Deep sequencing of the V3 region of the HIV envelope gene can detect minority non-R5 variants in patients with high sensitivity and specificity. As next-generation sequencing approaches have matured, the clinical utility of deep sequencing for HIV tropism has entered the clinic. Accurate and sensitive...

journal_title：Current opinion in HIV and AIDS

authors： Swenson LC,Däumer M,Paredes R

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution. RECENT FINDINGS:Characterization of archival samples showed that by the 1960s, HIV had already diverged within humans. It is now estimated that HIV has been in humans since at ...

journal_title：Current opinion in HIV and AIDS

authors： Woodman Z,Williamson C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...

journal_title：Current opinion in HIV and AIDS

authors： Rutstein SE,Sellers CJ,Ananworanich J,Cohen MS

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...

journal_title：Current opinion in HIV and AIDS

authors： Richardson SI,Moore PL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...

journal_title：Current opinion in HIV and AIDS

authors： Evangeli M

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...

journal_title：Current opinion in HIV and AIDS

authors： Heeney JL

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...

journal_title：Current opinion in HIV and AIDS

authors： Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...

journal_title：Current opinion in HIV and AIDS

authors： la Porte C

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...

journal_title：Current opinion in HIV and AIDS

authors： Utay NS,Hunt PW

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...

journal_title：Current opinion in HIV and AIDS

authors： Davies MA,Gibb D,Turkova A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L,Said EA,Halwani R,Janbazian L,Chomont N,El-Far M,Breton G,Haddad EK,Sekaly RP

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...

journal_title：Current opinion in HIV and AIDS

authors： Wright EJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Knowledge of HIV status is the gateway to HIV treatment and prevention, and optimizing this pillar is essential to bend the curve of the HIV epidemic toward zero new infections. This review will discuss the epidemiology of serostatus awareness, including disparities among key populations, and explore ...

journal_title：Current opinion in HIV and AIDS

authors： Thompson M

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00