Abstract:
PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antiretroviral treatment may play in the preservation of neurocognitive health in patients with more than 500 CD4+ cells/microl. RECENT FINDINGS:In the post highly active antiretroviral therapy (HAART) era, HIV-associated neurocognitive disorders remain prevalent and even mild-moderate immunosuppression carries a risk for the development of HIV-associated dementia. HIV infection of the CNS occurs early in the illness, and data suggest that a robust peripheral immune system is key to the long-term control of CNS HIV infection. HAART results in clinical, neuropsychological and neuroradiological improvement in patients with HIV-associated neurocognitive disorders, and the prescription of HAART regimens with good cerebrospinal fluid penetration appears to be preferable in this setting. There is little evidence that HAART causes CNS toxicity. The benefits and risks of HAART in the preservation or enhancement of neurocognitive function in well, HIV-infected patients with more than 500 CD4+ cells/microl are unknown. SUMMARY:The prescription of HAART in well, HIV-infected patients with high CD4+ cell counts may afford enhanced control of CNS HIV infection as a result of the benefits of HAART upon peripheral immune function. In turn, this may result in superior or preserved neurocognitive performance in comparison to the current practice of commencing HAART when CD4+ cells reach 350 cells/microl or lower. This hypothesis will be tested in an upcoming randomized clinical trial.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Wright EJdoi
10.1097/COH.0b013e32832dd0c2subject
Has Abstractpub_date
2009-09-01 00:00:00pages
447-52issue
5eissn
1746-630Xissn
1746-6318pii
01222929-200909000-00016journal_volume
4pub_type
社论,评审abstract:PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...
journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...
journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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更新日期:2009-11-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2010-05-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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更新日期:2013-07-01 00:00:00
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更新日期:2013-07-01 00:00:00
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更新日期:2010-07-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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更新日期:2007-01-01 00:00:00
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更新日期:2008-11-01 00:00:00