Th17 cell dynamics in HIV infection.

abstract：PURPOSE OF REVIEW:Approximately 150-175 million people are infected with hepatitis C virus (HCV). Until very recently, the complexity, cost and poor efficacy and tolerability of pegylated interferon and ribavirin (PEG-RBV) treatment have hindered scale up in low-income and middle-income countries (L&MICs). Similarly, t...

journal_title：Current opinion in HIV and AIDS

authors： Cohn J,Roberts T,Amorosa V,Lemoine M,Hill A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to summarize data in the last 18 months on the sexual and reproductive health of perinatally and horizontally infected adolescents and young people living with HIV (age 13-25 years) and to highlight some key issues faced by this group of adolescents as they reach puberty and sexual de...

journal_title：Current opinion in HIV and AIDS

authors： Hamzah L,Hamlyn E

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Highly active antiretroviral therapy has markedly reduced HIV morbidity and mortality in industrialized countries. Expanded access to the 6.5 million individuals in immediate need of antiretroviral therapy using a public-health-systems approach is now promulgated as an international policy. An approxi...

journal_title：Current opinion in HIV and AIDS

authors： Bekker LG,Egger M,Wood R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

journal_title：Current opinion in HIV and AIDS

authors： Sabin KM,Johnston LG

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...

journal_title：Current opinion in HIV and AIDS

authors： Kestens L,Seddiki N,Bohjanen PR

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...

journal_title：Current opinion in HIV and AIDS

authors： Secor WE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:RNA interference is a type of nucleic-acid-based immunity used by cells to restrict transposons, transgenes and viruses. The RNA interference machinery targets long double-stranded RNAs to produce short RNAs that arm cellular ribonucleases to degrade foreign RNAs in a sequence-specific manner. Despite...

journal_title：Current opinion in HIV and AIDS

authors： Bennasser Y,Yeung ML,Benkirane M,Jeang KT

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...

journal_title：Current opinion in HIV and AIDS

authors： Scully EP

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...

journal_title：Current opinion in HIV and AIDS

authors： Duerr A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

journal_title：Current opinion in HIV and AIDS

authors： Essex M,Makhema J,Lockman S

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...

journal_title：Current opinion in HIV and AIDS

authors： Reif LK,McNairy ML,Lamb MR,Fayorsey R,Elul B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...

journal_title：Current opinion in HIV and AIDS

authors： Lessells RJ,Swaminathan S,Godfrey-Faussett P

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...

journal_title：Current opinion in HIV and AIDS

authors： Mehandru S,Dandekar S

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we highlight the latest advances in HIV vaccine concepts that will expand our knowledge on how to elicit effective acquisition-prevention and/or control of simian immunodeficiency virus (SIV) replication in the nonhuman primate (NHP) model. RECENT FINDINGS:In the context of the promising analyse...

journal_title：Current opinion in HIV and AIDS

authors： Lynch RM,Yamamoto T,McDermott AB

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:It is generally accepted that a high degree of adherence to the dosing regimens of protease inhibitors is essential to avoid virological failure. It is also believed that once-daily dosing of protease inhibitors, by improving adherence, will lead to better outcomes. This review will discuss the patter...

journal_title：Current opinion in HIV and AIDS

authors： Blaschke TF

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...

journal_title：Current opinion in HIV and AIDS

authors： Rutstein SE,Sellers CJ,Ananworanich J,Cohen MS

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compare and contrast the application of molecular epidemiology approaches for the improved management and understanding of the HIV versus SARS-CoV-2 epidemics. RECENT FINDINGS:Molecular biology approaches, including PCR and whole genome sequencing (WGS), have become powe...

journal_title：Current opinion in HIV and AIDS

authors： Lorenzo-Redondo R,Ozer EA,Achenbach CJ,D'Aquila RT,Hultquist JF

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cancer, but no...

journal_title：Current opinion in HIV and AIDS

authors： Bernstein WB,Dennis PA

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to ef...

journal_title：Current opinion in HIV and AIDS

authors： Asbach B,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blame...

journal_title：Current opinion in HIV and AIDS

authors： Moran CA,Weitzmann MN,Ofotokun I

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

journal_title：Current opinion in HIV and AIDS

authors： Hall HI,Brooks JT,Mermin J

更新日期：2019-11-01 00:00:00