Abstract:
PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of prostate-specific antigen provides confirmation of condom use. A new weighting scheme based on frequency of venue attendance for time location samples should improve validity of data obtained with this method. Two new proportion estimators, new diagnostic methods, a new population size estimator and new analysis software will provide more robust results from respondent-driven sampling (RDS). SUMMARY:Analytical advances have improved the potential quality of results from surveys using time location and RDS. However, data from sufficient numbers of sites over sufficient number of years are still needed to provide clear national pictures of distribution and trends of HIV infection.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Sabin KM,Johnston LGdoi
10.1097/COH.0000000000000046subject
Has Abstractpub_date
2014-03-01 00:00:00pages
101-6issue
2eissn
1746-630Xissn
1746-6318journal_volume
9pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328351b9e3
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000241
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:It has been demonstrated that extensive virus diversification and antibody coevolution are necessary to give rise to broadly neutralizing antibodies targeting the envelope protein of HIV-1. Here, we discuss recent progress of vaccine design approaches aiming on strategies to initiate and guide B-cell ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000356
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000566
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000342
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. This review will outline the current epidemiology of HCV in HIV infection, focusing on the recent changes and factors which have been related to the increase in HCV transmission in HIV-infected men who h...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32834b4974
更新日期:2011-11-01 00:00:00
abstract:PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000595
更新日期:2020-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282fbaaba
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...
journal_title:Current opinion in HIV and AIDS
pub_type: 社论,评审
doi:10.1097/COH.0b013e32832dd0c2
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000454
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282f51b89
更新日期:2008-03-01 00:00:00
abstract:PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833860ba
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000616
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328011aad6
更新日期:2007-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328302ebbb
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282f331b0
更新日期:2008-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/coh.0b013e32831a6fe0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000232350.61650.f0
更新日期:2006-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32834ddc96
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283478757
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000203836.08974.96
更新日期:2006-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000580
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32832aa902
更新日期:2009-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is bein...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000160
更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Effective therapies have transformed HIV infection into a chronic disease, and new problems are arising related to aging. This article reviews the aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection. RECENT FINDINGS:Aging is characteri...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000070
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed recent literature on the role of family planning in eliminating new pediatric HIV infections. RECENT FINDINGS:Global commitments to eliminate new pediatric HIV infections recognize that preventing unintended pregnancies among women with HIV is essential to achieving this goal. However, su...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283632bd7
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833d2e39
更新日期:2010-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review recent advances in the clinical care of HIV-infected children. RECENT FINDINGS:Obstacles to diagnosing HIV in children and providing clinical care to those HIV infected relate to a number of technical and operational factors. Most countries now have antiretroviral...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282ddedf5
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32834ddcd9
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000286
更新日期:2016-07-01 00:00:00