Abstract:
PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the role of the gastrointestinal tract in HIV-1 pathogenesis. RECENT FINDINGS:High levels of viral replication in the gastrointestinal mucosa during primary HIV and simian immunodeficiency virus infections lead to severe depletion of effector memory CD4 T cells coinciding with increased immune activation and mucosal damage. Viral reservoirs established at this stage appear to be persistent over the course of infection and during therapy. In the simian immunodeficiency virus model of AIDS, onset of the impaired intestinal epithelial barrier function and renewal was observed during primary viral infection. Dysfunction of the mucosal immune system and the epithelial barrier may contribute to viral persistence and impaired responses to microbial pathogens in infected individuals. SUMMARY:A better understanding of the impact of HIV infection on the mucosal immune system may help in the development of newer preventive and therapeutic strategies directed against the virus.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Mehandru S,Dandekar Sdoi
10.1097/COH.0b013e3282f331b0subject
Has Abstractpub_date
2008-01-01 00:00:00pages
22-7issue
1eissn
1746-630Xissn
1746-6318pii
01222929-200801000-00006journal_volume
3pub_type
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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更新日期:2006-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2018-05-01 00:00:00