Evaluation and management of early virological failure.

abstract：PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...

journal_title：Current opinion in HIV and AIDS

authors： Heeney JL

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed recent literature on the role of family planning in eliminating new pediatric HIV infections. RECENT FINDINGS:Global commitments to eliminate new pediatric HIV infections recognize that preventing unintended pregnancies among women with HIV is essential to achieving this goal. However, su...

journal_title：Current opinion in HIV and AIDS

authors： Wilcher R,Petruney T,Cates W

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...

journal_title：Current opinion in HIV and AIDS

authors： Reif LK,McNairy ML,Lamb MR,Fayorsey R,Elul B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...

journal_title：Current opinion in HIV and AIDS

authors： Clotet B,Paredes R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...

journal_title：Current opinion in HIV and AIDS

authors： Shahid S,Majeed MF,Awaan AB,Mirza H,Sarfraz N,Veronese V

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...

journal_title：Current opinion in HIV and AIDS

authors： De Francesco D,Sabin CA,Reiss P

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blame...

journal_title：Current opinion in HIV and AIDS

authors： Moran CA,Weitzmann MN,Ofotokun I

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Approximately 150-175 million people are infected with hepatitis C virus (HCV). Until very recently, the complexity, cost and poor efficacy and tolerability of pegylated interferon and ribavirin (PEG-RBV) treatment have hindered scale up in low-income and middle-income countries (L&MICs). Similarly, t...

journal_title：Current opinion in HIV and AIDS

authors： Cohn J,Roberts T,Amorosa V,Lemoine M,Hill A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...

journal_title：Current opinion in HIV and AIDS

authors： Evangeli M

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

journal_title：Current opinion in HIV and AIDS

authors： Orsi F,d'almeida C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract. RECENT FINDINGS:Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentration...

journal_title：Current opinion in HIV and AIDS

authors： Taylor S,Davies S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...

journal_title：Current opinion in HIV and AIDS

authors： Allweiss L,Strick-Marchand H

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...

journal_title：Current opinion in HIV and AIDS

authors： Rueda S,Law S,Rourke SB

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...

journal_title：Current opinion in HIV and AIDS

authors： Lori F,Foli A,Lisziewicz J

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...

journal_title：Current opinion in HIV and AIDS

authors： Kestens L,Seddiki N,Bohjanen PR

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. RECENT FINDINGS:Most studies show that HIV-infected adults hav...

journal_title：Current opinion in HIV and AIDS

authors： Koay WLA,Siems LV,Persaud D

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...

journal_title：Current opinion in HIV and AIDS

authors： Grund B,Sabin C

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore the possible role of current prophylactic vaccines against human papillomavirus (HPV) in the prevention of anal intraepithelial neoplasia and squamous cell carcinoma of the anus (SCCA). RECENT FINDINGS:SCCA incidence is increasing in several developed countries, particularly in HIV-positiv...

journal_title：Current opinion in HIV and AIDS

authors： Franceschi S,De Vuyst H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The available vaccine and therapies against hepatitis B virus (HBV) rarely eliminate chronic infection with the virus. High mortality resulting from complicating cirrhosis and hepatocellular carcinoma makes improving anti-HBV therapy an important priority. Recent advances with using gene therapy to co...

journal_title：Current opinion in HIV and AIDS

authors： Maepa MB,Jacobs R,van den Berg F,Arbuthnot P

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burd...

journal_title：Current opinion in HIV and AIDS

authors： Althoff KN,Smit M,Reiss P,Justice AC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...

journal_title：Current opinion in HIV and AIDS

authors： Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...

journal_title：Current opinion in HIV and AIDS

authors： Law MG

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...

journal_title：Current opinion in HIV and AIDS

authors： Lessells RJ,Swaminathan S,Godfrey-Faussett P

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity ...

journal_title：Current opinion in HIV and AIDS

authors： Margolis DM

更新日期：2011-01-01 00:00:00