Histone deacetylase inhibitors and HIV latency.

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...

journal_title：Current opinion in HIV and AIDS

authors： Boyer S,Koulla-Shiro S,Abé C,Spire B,Moatti JP

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

journal_title：Current opinion in HIV and AIDS

authors： Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It is generally accepted that a high degree of adherence to the dosing regimens of protease inhibitors is essential to avoid virological failure. It is also believed that once-daily dosing of protease inhibitors, by improving adherence, will lead to better outcomes. This review will discuss the patter...

journal_title：Current opinion in HIV and AIDS

authors： Blaschke TF

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...

journal_title：Current opinion in HIV and AIDS

authors： Lessells RJ,Swaminathan S,Godfrey-Faussett P

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...

journal_title：Current opinion in HIV and AIDS

authors： Heeney JL

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern interferon (IFN)-free, and potentially also ribavirin-free, combinations consisting of two or three direct-acting antivirals (DAAs) are highly efficacious in treating chronic hepatitis C virus (HCV) infection with treatment durations being much shorter and with much more favorable toxicity prof...

journal_title：Current opinion in HIV and AIDS

authors： Boesecke C,Page E

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...

journal_title：Current opinion in HIV and AIDS

authors： Rutstein SE,Sellers CJ,Ananworanich J,Cohen MS

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, we describe the challenges faced by using clinical cohorts to perform Monitoring and Evaluation (M&E) and the possible solutions for increasing and strengthening health systems in low-income and middle-income countries. RECENT FINDINGS:HIV scale-up has facilitated the transition from ...

journal_title：Current opinion in HIV and AIDS

authors： Ekouevi DK,Karcher S,Coffie PA

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...

journal_title：Current opinion in HIV and AIDS

authors： Allweiss L,Strick-Marchand H

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. RECENT FINDINGS:DTG has been teste...

journal_title：Current opinion in HIV and AIDS

authors： Cahn P

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. RECENT FINDINGS:CALWH benefit less from Bacille-Calmette Guerin vaccination than HIV-un...

journal_title：Current opinion in HIV and AIDS

authors： Kay A,Garcia-Prats AJ,Mandalakas AM

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Although there has been a significant increase in mHealth interventions addressing the HIV prevention and care continuum, interventions using game mechanics have been less explored. Digital games are rapidly becoming an important tool for improving health behaviors and supporting the delivery of care ...

journal_title：Current opinion in HIV and AIDS

authors： Hightow-Weidman LB,Muessig KE,Bauermeister JA,LeGrand S,Fiellin LE

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Highly active antiretroviral therapy has markedly reduced HIV morbidity and mortality in industrialized countries. Expanded access to the 6.5 million individuals in immediate need of antiretroviral therapy using a public-health-systems approach is now promulgated as an international policy. An approxi...

journal_title：Current opinion in HIV and AIDS

authors： Bekker LG,Egger M,Wood R

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

journal_title：Current opinion in HIV and AIDS

authors： Essex M,Makhema J,Lockman S

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:RNA interference is a type of nucleic-acid-based immunity used by cells to restrict transposons, transgenes and viruses. The RNA interference machinery targets long double-stranded RNAs to produce short RNAs that arm cellular ribonucleases to degrade foreign RNAs in a sequence-specific manner. Despite...

journal_title：Current opinion in HIV and AIDS

authors： Bennasser Y,Yeung ML,Benkirane M,Jeang KT

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...

journal_title：Current opinion in HIV and AIDS

authors： Van Tieu H,Koblin BA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...

journal_title：Current opinion in HIV and AIDS

authors： la Porte C

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blame...

journal_title：Current opinion in HIV and AIDS

authors： Moran CA,Weitzmann MN,Ofotokun I

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...

journal_title：Current opinion in HIV and AIDS

authors： Alvarez E,Belloso WH,Boyd MA,Inkaya AÇ,Hsieh E,Kambugu A,Kaminski G,Martinez E,Stellbrink HJ,Walmsley S,Brown TT,Mallon PW

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

journal_title：Current opinion in HIV and AIDS

authors： Sabin KM,Johnston LG

更新日期：2014-03-01 00:00:00