Abstract:
PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in experienced patients. Data from recent clinical studies investigating inhibitory quotient cutoffs to be used in therapeutic drug monitoring will be reviewed. In addition points for discussion regarding the use and study of inhibitory quotients will be presented. RECENT FINDINGS:A number of studies generated data on the use of the inhibitory quotient in general and the genotypic inhibitory quotient in particular. Most of these studies define a cutoff inhibitory quotient value, above which the virological response rate is higher. These cutoff values can be used in therapeutic drug monitoring and give guidance to the clinician on dose adjustments. Genotypic inhibitory quotient cutoff values are available for amprenavir, atazanavir, darunavir, lopinavir, saquinavir and tipranavir. SUMMARY:The inhibitory quotient is becoming a valuable tool in therapeutic drug monitoring. At this moment most data are available for the genotypic inhibitory quotient. Nevertheless, a consensus needs to be reached on a number of items, including the methods to study inhibitory quotient as well as the mathematical and virological background.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
la Porte Cdoi
10.1097/COH.0b013e3282fbaabasubject
Has Abstractpub_date
2008-05-01 00:00:00pages
283-7issue
3eissn
1746-630Xissn
1746-6318pii
01222929-200805000-00015journal_volume
3pub_type
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32801470f6
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2008-11-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2015-11-01 00:00:00