Microbicides: chemistry, structure, and strategy.

Abstract:

PURPOSE OF REVIEW:To highlight promising areas of research and preview future generations of microbicides, this review will focus on reports that described new cellular or viral targets, drug substances, or strategies that are specifically intended for topical microbicides. Those reports that dealt with the design, discovery, and synthesis of anti-HIV agents for use in oral or parenteral formulations, while important for the microbicide field, are beyond the scope of this review. RECENT FINDINGS:Drug substances intended for topical microbicides are becoming increasingly target specific and, structurally, more complex. New production methods might reduce the cost of microbicides that contain these complex molecules. Genetically engineered probiotic vaginal bacteria express an even wider range of antiviral compounds, perhaps resulting in uninterrupted, coitally independent protection. Combination microbicides that contain two or more drug substances frequently act synergistically. The discovery of new cellular targets such as syndecan-3 might lead to more effective microbicides. SUMMARY:Future generations of microbicides will likely contain one or more complex or highly specific drug substances, resulting in safer and more effective products. Since compliance issues continue to confound HIV and herpes simplex virus trials, efforts to bring practical, coitally independent microbicides to developing countries will become a top priority.

journal_name

Curr Opin HIV AIDS

authors

Zydowsky TM

doi

10.1097/COH.0b013e32830ab9dd

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

548-53

issue

5

eissn

1746-630X

issn

1746-6318

pii

01222929-200809000-00005

journal_volume

3

pub_type

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