Abstract:
PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burden of harmful health behaviours, injury from HIV infection, HIV treatment toxicity and general burden of age-associated comorbidities. In turn, these factors contribute to geriatric syndromes including multimorbidity and polypharmacy, physiologic frailty, falls and fragility fractures and cognitive dysfunction, which further compromise the quality of life long before they lead to mortality. SUMMARY:Viral suppression of HIV with combination antiviral therapy has led to increasing longevity but has not enabled a complete return to health among ageing HIV-infected individuals (HIV+). As adults age with HIV, the role of HIV itself and associated inflammation, effects of exposure to antiretroviral agents, the high prevalence of modifiable risk factors for age-associated conditions (e.g. smoking), and the effects of other viral coinfections are all influencing the health trajectory of persons ageing with HIV. We must move from the simplistic notion of HIV becoming a 'chronic controllable illness' to understanding the continually evolving 'treated' history of HIV infection with the burden of age-associated conditions and geriatric syndromes in the context of an altered and ageing immune system.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Althoff KN,Smit M,Reiss P,Justice ACdoi
10.1097/COH.0000000000000305subject
Has Abstractpub_date
2016-09-01 00:00:00pages
527-536issue
5eissn
1746-630Xissn
1746-6318journal_volume
11pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328363d389
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Th17 cells are a newly identified subtype of CD4 T cells that respond to bacterial and fungal antigens and are important in mucosal immunology. Because HIV infection results in loss of CD4 T cells as well as disruption to the gastrointestinal tract that causes microbial translocation and immune activa...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283364846
更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000247389.08485.87
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is establi...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32832f00c0
更新日期:2009-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000046
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cancer, but no...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328313915d
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000451
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The available vaccine and therapies against hepatitis B virus (HBV) rarely eliminate chronic infection with the virus. High mortality resulting from complicating cirrhosis and hepatocellular carcinoma makes improving anti-HBV therapy an important priority. Recent advances with using gene therapy to co...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000623
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328344f35e
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Significant gastrointestinal pathology occurs in progressive HIV and simian immunodeficiency virus (SIV) infections. This review will examine the relationship between the detrimental events to the gastrointestinal tract during the acute phase of infection and disease progression through the chronic ph...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282f9ae9c
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Approximately 150-175 million people are infected with hepatitis C virus (HCV). Until very recently, the complexity, cost and poor efficacy and tolerability of pegylated interferon and ribavirin (PEG-RBV) treatment have hindered scale up in low-income and middle-income countries (L&MICs). Similarly, t...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000180
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328341242d
更新日期:2011-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Highly active antiretroviral therapy has markedly reduced HIV morbidity and mortality in industrialized countries. Expanded access to the 6.5 million individuals in immediate need of antiretroviral therapy using a public-health-systems approach is now promulgated as an international policy. An approxi...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3281e72cbd
更新日期:2007-07-01 00:00:00
abstract:PURPOSE OF REVIEW:A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to ef...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000366
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32830634c6
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000071
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The epidemiology of HIV epidemics provides the roadmap for prioritization of programmes and serves over time to evaluate broadly the successes and challenges in prevention. The purpose of this review was to summarize recent information about the epidemiology of HIV in high-income countries with concen...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000039
更新日期:2014-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Nonhuman primate (NHP) models of AIDS are powerful systems for evaluating HIV vaccine approaches in vivo. Authentic features of HIV-1 transmission, dissemination, target cell tropism, and pathogenesis, and aspects of anti-HIV-1 immune responses, can be recapitulated in NHPs provided the appropriate, s...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000311
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000454
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32801470f6
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000554
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32834ddcd9
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:With the introduction of combined antiretroviral therapy (cART) and consequent reduction in the incidence of AIDS-related mortality, there has been a relative increase in the importance of non-AIDS-related conditions such as liver disease. This article reviews the positive and potential negative impac...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000022
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283536ab2
更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833a51b2
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this paper is to assess the contribution of antiretroviral therapy to cardiovascular disease, by evaluating relevant clinical and surrogate outcome studies. RECENT FINDINGS:A large proportion of patients receiving antiretroviral therapy develop insulin resistance and dyslipidemia, particul...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282fb7bcf
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Here we highlight the latest advances in HIV vaccine concepts that will expand our knowledge on how to elicit effective acquisition-prevention and/or control of simian immunodeficiency virus (SIV) replication in the nonhuman primate (NHP) model. RECENT FINDINGS:In the context of the promising analyse...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328361cfe8
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is bein...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000160
更新日期:2015-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328351b9e3
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...
journal_title:Current opinion in HIV and AIDS
pub_type: 社论,评审
doi:10.1097/COH.0b013e32832dd0c2
更新日期:2009-09-01 00:00:00