Abstract:
PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most intensively in treatment-experienced patients and is the first integrase inhibitor that has been licensed for use in this patient group. Most studies have shown good tolerability data and very potent virus suppression. In patients with limited treatment options, switching from enfuvirtide appears to be well tolerated, whereas switching from a protease inhibitor-based regimen may increase the rates of viral failure. Elvitegravir also showed good results in early phase clinical trials and is currently undergoing phase III clinical trials. SUMMARY:Given that integrase inhibitors belong to a new class of antiretroviral agents with a diverse drug resistance profile, and are active against both chemokine (C-C motif) receptor 5 and chemokine (C-X-C motif) receptor 4 strains, they are exciting additions to salvage therapy regimen. Raltegravir and elvitegravir are metabolized via different pathways, which will affect their respective use. The major limitation for the use of integrase inhibitors is a potentially low threshold for viral drug resistance, so functional monotherapy must be avoided.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Koelsch KK,Cooper DAdoi
10.1097/COH.0b013e328331b526subject
Has Abstractpub_date
2009-11-01 00:00:00pages
518-23issue
6eissn
1746-630Xissn
1746-6318pii
01222929-200911000-00011journal_volume
4pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...
journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:Despite significant technical advances that have permitted an increasingly more quantitative and detailed study of virus-specific cellular immunity over the past few years, our understanding of the nature of immunological control in rare cases of non-progressive HIV infection and diminished control in...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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abstract:PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000022
更新日期:2014-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/coh.0b013e32831a6fe0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review is to summarize the current standards of care for both HIV treatment and HIV prevention in 2019. RECENT FINDINGS:Current HIV treatment is started as soon as feasible in a person with HIV infection and consists of a three-drug oral daily antiretroviral regimen, consisting of...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 社论,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2017-09-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283478757
更新日期:2011-07-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000356
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833ed774
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000102
更新日期:2014-11-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000221593.49412.56
更新日期:2006-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000616
更新日期:2020-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Significant gastrointestinal pathology occurs in progressive HIV and simian immunodeficiency virus (SIV) infections. This review will examine the relationship between the detrimental events to the gastrointestinal tract during the acute phase of infection and disease progression through the chronic ph...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282f9ae9c
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833a0b69
更新日期:2010-07-01 00:00:00
abstract:PURPOSE OF REVIEW:For the first time in decades, there are multiple new drugs in the pipeline for the treatment of tuberculosis (TB). In addition, existing drugs are being repurposed or optimized for TB with the goal of shortened treatment duration for drug-sensitive TB and safer, shorter treatments for multidrug-resis...
journal_title:Current opinion in HIV and AIDS
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更新日期:2013-11-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2021-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833d2e39
更新日期:2010-09-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000046
更新日期:2014-03-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32832f00c0
更新日期:2009-09-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:In this review, we describe the challenges faced by using clinical cohorts to perform Monitoring and Evaluation (M&E) and the possible solutions for increasing and strengthening health systems in low-income and middle-income countries. RECENT FINDINGS:HIV scale-up has facilitated the transition from ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283479316
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328351b9e3
更新日期:2012-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Th17 cells are a newly identified subtype of CD4 T cells that respond to bacterial and fungal antigens and are important in mucosal immunology. Because HIV infection results in loss of CD4 T cells as well as disruption to the gastrointestinal tract that causes microbial translocation and immune activa...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283364846
更新日期:2010-03-01 00:00:00