Abstract:
PURPOSE OF REVIEW:The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is established. We review recent data on HIV-1-specific antibody isotypes induced following HIV-1 transmission: to understand the effects of HIV-1 on B cell and T cell effector responses, to understand the timing of the rise and fall of different anti-HIV-1 antibodies and to understand how antibodies could contribute to protective immunity if they were either pre-existing or elicited immediately after HIV-1 transmission. RECENT FINDINGS:Studies of the earliest events following infection by the transmitted/founder virus have recently revealed that early destruction of B cell generative microenvironments may be responsible for delay of potentially protective anti-HIV-1 antibody responses. Unlike the initial CD8 T cell response to HIV-1, the initial induced antibody response is usually ineffective in controlling virus replication during acute HIV-1 infection. SUMMARY:The antibody isotypes and specificities elicited during HIV-1 infection can provide a window into deciphering the detrimental effects of HIV-1 on B cell and T cell responses. Additionally, further characterization of the virus inhibitory capabilities of anti-HIV-1 antibody isotypes can define the spectrum of potential protective HIV-1 antibodies that could be readily elicited by experimental vaccines and adjuvants.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Tomaras GD,Haynes BFdoi
10.1097/COH.0b013e32832f00c0subject
Has Abstractpub_date
2009-09-01 00:00:00pages
373-9issue
5eissn
1746-630Xissn
1746-6318pii
01222929-200909000-00006journal_volume
4pub_type
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283536ab2
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journal_title:Current opinion in HIV and AIDS
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更新日期:2014-01-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...
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abstract:PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...
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journal_title:Current opinion in HIV and AIDS
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pub_type: 杂志文章,评审
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更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2018-11-01 00:00:00