Ethical considerations in HIV cure research: points to consider.

abstract：PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

journal_title：Current opinion in HIV and AIDS

authors： Sabin KM,Johnston LG

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...

journal_title：Current opinion in HIV and AIDS

authors： Girard MP,Plotkin SA

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

journal_title：Current opinion in HIV and AIDS

authors： Hall HI,Brooks JT,Mermin J

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonhuman primate (NHP) models of AIDS are powerful systems for evaluating HIV vaccine approaches in vivo. Authentic features of HIV-1 transmission, dissemination, target cell tropism, and pathogenesis, and aspects of anti-HIV-1 immune responses, can be recapitulated in NHPs provided the appropriate, s...

journal_title：Current opinion in HIV and AIDS

authors： Del Prete GQ,Lifson JD,Keele BF

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...

journal_title：Current opinion in HIV and AIDS

authors： Evangeli M

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed recent literature on the role of family planning in eliminating new pediatric HIV infections. RECENT FINDINGS:Global commitments to eliminate new pediatric HIV infections recognize that preventing unintended pregnancies among women with HIV is essential to achieving this goal. However, su...

journal_title：Current opinion in HIV and AIDS

authors： Wilcher R,Petruney T,Cates W

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...

journal_title：Current opinion in HIV and AIDS

authors： Boyd MA

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Small molecule inhibitors targeting the CCR5 coreceptor represent a new class of drugs for treating HIV-1 infection. Maraviroc has received regulatory approvals, and vicriviroc is in phase 3 trials. Understanding how resistance to these drugs develops and is diagnosed is essential to guide clinical pr...

journal_title：Current opinion in HIV and AIDS

authors： Moore JP,Kuritzkes DR

更新日期：2009-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cancer, but no...

journal_title：Current opinion in HIV and AIDS

authors： Bernstein WB,Dennis PA

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

journal_title：Current opinion in HIV and AIDS

authors： Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...

journal_title：Current opinion in HIV and AIDS

authors： Grund B,Sabin C

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...

journal_title：Current opinion in HIV and AIDS

authors： Parks CL,Picker LJ,King CR

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...

journal_title：Current opinion in HIV and AIDS

authors： Allweiss L,Strick-Marchand H

更新日期：2020-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract. RECENT FINDINGS:Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentration...

journal_title：Current opinion in HIV and AIDS

authors： Taylor S,Davies S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...

journal_title：Current opinion in HIV and AIDS

authors： De Francesco D,Sabin CA,Reiss P

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...

journal_title：Current opinion in HIV and AIDS

authors： Nachega JB,Mills EJ,Schechter M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution. RECENT FINDINGS:Characterization of archival samples showed that by the 1960s, HIV had already diverged within humans. It is now estimated that HIV has been in humans since at ...

journal_title：Current opinion in HIV and AIDS

authors： Woodman Z,Williamson C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV functional cure requires the elimination or a major reduction of HIV reservoir pool including male and female genital HIV reservoirs. A comprehensive understanding of HIV dynamics in these compartments is mandatory. RECENT FINDINGS:Data from chronically HIV-infected therapy-naïve individuals or f...

journal_title：Current opinion in HIV and AIDS

authors： Gantner P,Ghosn J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This review examines evidence regarding the differential effects of high dead-space syringes (HDSS) and low dead-space syringes (LDSS) on HIV transmission among people who inject drugs (PWID). It also identifies areas for additional research and examines potential barriers to interventions that promot...

journal_title：Current opinion in HIV and AIDS

authors： Zule WA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...

journal_title：Current opinion in HIV and AIDS

authors： Utay NS,Hunt PW

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

journal_title：Current opinion in HIV and AIDS

authors： Mayne ES,George JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...

journal_title：Current opinion in HIV and AIDS

authors： Wright EJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...

journal_title：Current opinion in HIV and AIDS

authors： Rueda S,Law S,Rourke SB

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is bein...

journal_title：Current opinion in HIV and AIDS

authors： Jackson A,McGowan I

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...

journal_title：Current opinion in HIV and AIDS

authors： Lori F,Foli A,Lisziewicz J

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...

journal_title：Current opinion in HIV and AIDS

authors： Richardson SI,Moore PL

更新日期：2019-07-01 00:00:00