Psychosocial, mental health, and behavioral issues of aging with HIV.

abstract：PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...

journal_title：Current opinion in HIV and AIDS

authors： Parks CL,Picker LJ,King CR

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

journal_title：Current opinion in HIV and AIDS

authors： Hall HI,Brooks JT,Mermin J

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...

journal_title：Current opinion in HIV and AIDS

authors： Lori F,Foli A,Lisziewicz J

更新日期：2007-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

journal_title：Current opinion in HIV and AIDS

authors： Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to ef...

journal_title：Current opinion in HIV and AIDS

authors： Asbach B,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV functional cure requires the elimination or a major reduction of HIV reservoir pool including male and female genital HIV reservoirs. A comprehensive understanding of HIV dynamics in these compartments is mandatory. RECENT FINDINGS:Data from chronically HIV-infected therapy-naïve individuals or f...

journal_title：Current opinion in HIV and AIDS

authors： Gantner P,Ghosn J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity ...

journal_title：Current opinion in HIV and AIDS

authors： Margolis DM

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...

journal_title：Current opinion in HIV and AIDS

authors： Davies MA,Gibb D,Turkova A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

journal_title：Current opinion in HIV and AIDS

authors： Mayne ES,George JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...

journal_title：Current opinion in HIV and AIDS

authors： Law MG

更新日期：2006-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemiology of HIV epidemics provides the roadmap for prioritization of programmes and serves over time to evaluate broadly the successes and challenges in prevention. The purpose of this review was to summarize recent information about the epidemiology of HIV in high-income countries with concen...

journal_title：Current opinion in HIV and AIDS

authors： Sullivan PS,Jones JS,Baral SD

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...

journal_title：Current opinion in HIV and AIDS

authors： Utay NS,Hunt PW

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore the possible role of current prophylactic vaccines against human papillomavirus (HPV) in the prevention of anal intraepithelial neoplasia and squamous cell carcinoma of the anus (SCCA). RECENT FINDINGS:SCCA incidence is increasing in several developed countries, particularly in HIV-positiv...

journal_title：Current opinion in HIV and AIDS

authors： Franceschi S,De Vuyst H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...

journal_title：Current opinion in HIV and AIDS

authors： Reif LK,McNairy ML,Lamb MR,Fayorsey R,Elul B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...

journal_title：Current opinion in HIV and AIDS

authors： Sereti I,Rodger AJ,French MA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...

journal_title：Current opinion in HIV and AIDS

authors： Secor WE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although there has been a significant increase in mHealth interventions addressing the HIV prevention and care continuum, interventions using game mechanics have been less explored. Digital games are rapidly becoming an important tool for improving health behaviors and supporting the delivery of care ...

journal_title：Current opinion in HIV and AIDS

authors： Hightow-Weidman LB,Muessig KE,Bauermeister JA,LeGrand S,Fiellin LE

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:As understanding and integrating the structural and biomedical determinants of HIV infection is essential for the success of prevention efforts, there is a need for biomedical and social scientists to work together. RECENT FINDINGS:A review of the biomedical research literature indicates that the two...

journal_title：Current opinion in HIV and AIDS

authors： Kippax S

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to describe progress in research and development of vaccines to prevent HIV/AIDS, emphasizing clinical trials and human studies published during the past year. RECENT FINDINGS:Clinical trial design depends, in large part, on whether vaccines are expected to provide protecti...

journal_title：Current opinion in HIV and AIDS

authors： Fast PE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:It has been demonstrated that extensive virus diversification and antibody coevolution are necessary to give rise to broadly neutralizing antibodies targeting the envelope protein of HIV-1. Here, we discuss recent progress of vaccine design approaches aiming on strategies to initiate and guide B-cell ...

journal_title：Current opinion in HIV and AIDS

authors： Peterhoff D,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

journal_title：Current opinion in HIV and AIDS

authors： Essex M,Makhema J,Lockman S

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:For the first time in decades, there are multiple new drugs in the pipeline for the treatment of tuberculosis (TB). In addition, existing drugs are being repurposed or optimized for TB with the goal of shortened treatment duration for drug-sensitive TB and safer, shorter treatments for multidrug-resis...

journal_title：Current opinion in HIV and AIDS

authors： Dooley KE,Nuermberger EL,Diacon AH

更新日期：2013-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

journal_title：Current opinion in HIV and AIDS

authors： Orsi F,d'almeida C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burd...

journal_title：Current opinion in HIV and AIDS

authors： Althoff KN,Smit M,Reiss P,Justice AC

更新日期：2016-09-01 00:00:00