Pipeline of drugs for related diseases: tuberculosis.

abstract：PURPOSE OF REVIEW:Interest has re-emerged in approaches to eradicate HIV infection. A series of modifications of nucleosomal histones within chromatin are a key mechanism of HIV gene regulation that alters the recruitment of transcription factors to viral DNA. The balance of these histone modifications in the vicinity ...

journal_title：Current opinion in HIV and AIDS

authors： Margolis DM

更新日期：2011-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...

journal_title：Current opinion in HIV and AIDS

authors： Clotet B,Paredes R

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...

journal_title：Current opinion in HIV and AIDS

authors： Richardson SI,Moore PL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The interaction between fall and fracture risk factors is an area of increasing clinical relevance, but little information is known about the age-specific issues in bone health unique to HIV-infected adults. The present review will focus on what is known about falls and fall risk factors among HIV-inf...

journal_title：Current opinion in HIV and AIDS

authors： Erlandson KM,Guaraldi G,Falutz J

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this paper is to assess the contribution of antiretroviral therapy to cardiovascular disease, by evaluating relevant clinical and surrogate outcome studies. RECENT FINDINGS:A large proportion of patients receiving antiretroviral therapy develop insulin resistance and dyslipidemia, particul...

journal_title：Current opinion in HIV and AIDS

authors： Friis-Møller N,Smieja M,Klein D

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the causes, evaluation, and management of early virological failure in patients treated with their first antiretroviral regimen. RECENT FINDINGS:Combination antiretroviral therapy predictably induces a rapid virological response, with the majority of patients achieving an undetectable HIV...

journal_title：Current opinion in HIV and AIDS

authors： Sax PE

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution. RECENT FINDINGS:Characterization of archival samples showed that by the 1960s, HIV had already diverged within humans. It is now estimated that HIV has been in humans since at ...

journal_title：Current opinion in HIV and AIDS

authors： Woodman Z,Williamson C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...

journal_title：Current opinion in HIV and AIDS

authors： Rutstein SE,Sellers CJ,Ananworanich J,Cohen MS

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L,Said EA,Halwani R,Janbazian L,Chomont N,El-Far M,Breton G,Haddad EK,Sekaly RP

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Although there has been a significant increase in mHealth interventions addressing the HIV prevention and care continuum, interventions using game mechanics have been less explored. Digital games are rapidly becoming an important tool for improving health behaviors and supporting the delivery of care ...

journal_title：Current opinion in HIV and AIDS

authors： Hightow-Weidman LB,Muessig KE,Bauermeister JA,LeGrand S,Fiellin LE

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...

journal_title：Current opinion in HIV and AIDS

authors： Wright EJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...

journal_title：Current opinion in HIV and AIDS

authors： Nachega JB,Mills EJ,Schechter M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Effective therapies have transformed HIV infection into a chronic disease, and new problems are arising related to aging. This article reviews the aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection. RECENT FINDINGS:Aging is characteri...

journal_title：Current opinion in HIV and AIDS

authors： Brothers TD,Rockwood K

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...

journal_title：Current opinion in HIV and AIDS

authors： Duerr A

更新日期：2010-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...

journal_title：Current opinion in HIV and AIDS

authors： El-Bassel N,Wechsberg WM,Shaw SA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Natural killer (NK) cells promote antiviral immunity by producing proinflammatory cytokines and by lysing infected cells. In addition, NK cells can modulate dendritic cell functions. NK-dendritic cell crosstalk results in activation of both cell types, with dendritic cells promoting NK-cell activity a...

journal_title：Current opinion in HIV and AIDS

authors： Gougeon ML,Bras M

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:RNA interference is a type of nucleic-acid-based immunity used by cells to restrict transposons, transgenes and viruses. The RNA interference machinery targets long double-stranded RNAs to produce short RNAs that arm cellular ribonucleases to degrade foreign RNAs in a sequence-specific manner. Despite...

journal_title：Current opinion in HIV and AIDS

authors： Bennasser Y,Yeung ML,Benkirane M,Jeang KT

更新日期：2006-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...

journal_title：Current opinion in HIV and AIDS

authors： Kestens L,Seddiki N,Bohjanen PR

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...

journal_title：Current opinion in HIV and AIDS

authors： Utay NS,Hunt PW

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract. RECENT FINDINGS:Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentration...

journal_title：Current opinion in HIV and AIDS

authors： Taylor S,Davies S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed recent literature on the role of family planning in eliminating new pediatric HIV infections. RECENT FINDINGS:Global commitments to eliminate new pediatric HIV infections recognize that preventing unintended pregnancies among women with HIV is essential to achieving this goal. However, su...

journal_title：Current opinion in HIV and AIDS

authors： Wilcher R,Petruney T,Cates W

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight promising areas of research and preview future generations of microbicides, this review will focus on reports that described new cellular or viral targets, drug substances, or strategies that are specifically intended for topical microbicides. Those reports that dealt with the design, dis...

journal_title：Current opinion in HIV and AIDS

authors： Zydowsky TM

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. RECENT FINDINGS:Most studies show that HIV-infected adults hav...

journal_title：Current opinion in HIV and AIDS

authors： Koay WLA,Siems LV,Persaud D

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...

journal_title：Current opinion in HIV and AIDS

authors： Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.

更新日期：2007-11-01 00:00:00