HIV vaccine development at the turn of the 21st century.

abstract：PURPOSE OF REVIEW:With the introduction of combined antiretroviral therapy (cART) and consequent reduction in the incidence of AIDS-related mortality, there has been a relative increase in the importance of non-AIDS-related conditions such as liver disease. This article reviews the positive and potential negative impac...

journal_title：Current opinion in HIV and AIDS

authors： Allen J,Smith C,Bhagani S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Effective therapies have transformed HIV infection into a chronic disease, and new problems are arising related to aging. This article reviews the aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection. RECENT FINDINGS:Aging is characteri...

journal_title：Current opinion in HIV and AIDS

authors： Brothers TD,Rockwood K

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...

journal_title：Current opinion in HIV and AIDS

authors： Shahid S,Majeed MF,Awaan AB,Mirza H,Sarfraz N,Veronese V

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

journal_title：Current opinion in HIV and AIDS

authors： Orsi F,d'almeida C

更新日期：2010-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...

journal_title：Current opinion in HIV and AIDS

authors： Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to describe progress in research and development of vaccines to prevent HIV/AIDS, emphasizing clinical trials and human studies published during the past year. RECENT FINDINGS:Clinical trial design depends, in large part, on whether vaccines are expected to provide protecti...

journal_title：Current opinion in HIV and AIDS

authors： Fast PE

更新日期：2006-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...

journal_title：Current opinion in HIV and AIDS

authors： Nachega JB,Mills EJ,Schechter M

更新日期：2010-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...

journal_title：Current opinion in HIV and AIDS

authors： Wright EJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...

journal_title：Current opinion in HIV and AIDS

authors： Grund B,Sabin C

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...

journal_title：Current opinion in HIV and AIDS

authors： Clotet B,Paredes R

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Deep sequencing of the V3 region of the HIV envelope gene can detect minority non-R5 variants in patients with high sensitivity and specificity. As next-generation sequencing approaches have matured, the clinical utility of deep sequencing for HIV tropism has entered the clinic. Accurate and sensitive...

journal_title：Current opinion in HIV and AIDS

authors： Swenson LC,Däumer M,Paredes R

更新日期：2012-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this paper is to assess the contribution of antiretroviral therapy to cardiovascular disease, by evaluating relevant clinical and surrogate outcome studies. RECENT FINDINGS:A large proportion of patients receiving antiretroviral therapy develop insulin resistance and dyslipidemia, particul...

journal_title：Current opinion in HIV and AIDS

authors： Friis-Møller N,Smieja M,Klein D

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Natural killer (NK) cells promote antiviral immunity by producing proinflammatory cytokines and by lysing infected cells. In addition, NK cells can modulate dendritic cell functions. NK-dendritic cell crosstalk results in activation of both cell types, with dendritic cells promoting NK-cell activity a...

journal_title：Current opinion in HIV and AIDS

authors： Gougeon ML,Bras M

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...

journal_title：Current opinion in HIV and AIDS

authors： Wu L

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Early studies have cast doubt on the utility of animal models for predicting success or failure of HIV-prevention strategies, but results of multiple human phase 3 microbicide trials, and interrogations into the discrepancies between human and animal model trials, indicate that animal models were, and...

journal_title：Current opinion in HIV and AIDS

authors： Veazey RS

更新日期：2013-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite significant technical advances that have permitted an increasingly more quantitative and detailed study of virus-specific cellular immunity over the past few years, our understanding of the nature of immunological control in rare cases of non-progressive HIV infection and diminished control in...

journal_title：Current opinion in HIV and AIDS

authors： Migueles SA,Tilton JC,Connors M

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...

journal_title：Current opinion in HIV and AIDS

authors： Scully EP

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. RECENT FINDINGS:Most studies show that HIV-infected adults hav...

journal_title：Current opinion in HIV and AIDS

authors： Koay WLA,Siems LV,Persaud D

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonhuman primate (NHP) models of AIDS are powerful systems for evaluating HIV vaccine approaches in vivo. Authentic features of HIV-1 transmission, dissemination, target cell tropism, and pathogenesis, and aspects of anti-HIV-1 immune responses, can be recapitulated in NHPs provided the appropriate, s...

journal_title：Current opinion in HIV and AIDS

authors： Del Prete GQ,Lifson JD,Keele BF

更新日期：2016-11-01 00:00:00