Abstract:
PURPOSE OF REVIEW:With the introduction of combined antiretroviral therapy (cART) and consequent reduction in the incidence of AIDS-related mortality, there has been a relative increase in the importance of non-AIDS-related conditions such as liver disease. This article reviews the positive and potential negative impact of cART on liver-related morbidity and mortality. RECENT FINDINGS:Though non-AIDS-related mortality, and particular, liver disease now accounts for a larger proportion of deaths in HIV-positive individuals than we have previously seen, liver-related mortality is decreasing. This is likely to be as a result of both the use of cART and improved patient management. Most liver-related mortality is related with viral hepatitis, the outcomes of which are improved with cART. Serious hepatotoxicity and death from cART is rare and mainly attributable to older antiretroviral drugs. SUMMARY:This review shows that outcomes are improving, but more work is required to improve liver-related morbidity and mortality further and determine any other longer-term positive and negative effects of cART.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Allen J,Smith C,Bhagani Sdoi
10.1097/COH.0000000000000022subject
Has Abstractpub_date
2014-01-01 00:00:00pages
48-53issue
1eissn
1746-630Xissn
1746-6318journal_volume
9pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Modern interferon (IFN)-free, and potentially also ribavirin-free, combinations consisting of two or three direct-acting antivirals (DAAs) are highly efficacious in treating chronic hepatitis C virus (HCV) infection with treatment durations being much shorter and with much more favorable toxicity prof...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....
journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...
journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...
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journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:As understanding and integrating the structural and biomedical determinants of HIV infection is essential for the success of prevention efforts, there is a need for biomedical and social scientists to work together. RECENT FINDINGS:A review of the biomedical research literature indicates that the two...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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更新日期:2018-05-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
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更新日期:2016-05-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000399
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328333ad61
更新日期:2010-01-01 00:00:00
abstract:PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2012-07-01 00:00:00
abstract:PURPOSE OF REVIEW:T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and ho...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...
journal_title:Current opinion in HIV and AIDS
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
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更新日期:2010-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...
journal_title:Current opinion in HIV and AIDS
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abstract:PURPOSE OF REVIEW:Early studies have cast doubt on the utility of animal models for predicting success or failure of HIV-prevention strategies, but results of multiple human phase 3 microbicide trials, and interrogations into the discrepancies between human and animal model trials, indicate that animal models were, and...
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journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282fbaaba
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...
journal_title:Current opinion in HIV and AIDS
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更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
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更新日期:2008-09-01 00:00:00