Direct-acting antiviral-based therapy for acute hepatitis C coinfection.

abstract：PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

journal_title：Current opinion in HIV and AIDS

authors： Essex M,Makhema J,Lockman S

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...

journal_title：Current opinion in HIV and AIDS

authors： De Francesco D,Sabin CA,Reiss P

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...

journal_title：Current opinion in HIV and AIDS

authors： Lobritz MA,Lassen KG,Arts EJ

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this review was to compare and contrast the application of molecular epidemiology approaches for the improved management and understanding of the HIV versus SARS-CoV-2 epidemics. RECENT FINDINGS:Molecular biology approaches, including PCR and whole genome sequencing (WGS), have become powe...

journal_title：Current opinion in HIV and AIDS

authors： Lorenzo-Redondo R,Ozer EA,Achenbach CJ,D'Aquila RT,Hultquist JF

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review current data on HIV-1 resistance arising from the use of fixed dose combination tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for preexposure prophylaxis (PrEP) to prevent HIV-1 infection. RECENT FINDINGS:Resistance to tenofovir (TNV) or FTC is infrequently selected by TDF/FTC PrEP ...

journal_title：Current opinion in HIV and AIDS

authors： Parikh UM,Mellors JW

更新日期：2016-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract. RECENT FINDINGS:Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentration...

journal_title：Current opinion in HIV and AIDS

authors： Taylor S,Davies S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Research directed toward an HIV cure presents ethical as well as scientific challenges. RECENT FINDINGS:International guidelines, regulations, and the medical literature provide helpful guidance on protecting research participants. SUMMARY:This review presents points to consider for researchers, spo...

journal_title：Current opinion in HIV and AIDS

authors： Lo B,Grady C,Working Group on Ethics of the International AIDS Society.

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. RECENT FINDINGS:DTG has been teste...

journal_title：Current opinion in HIV and AIDS

authors： Cahn P

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Nonhuman primate (NHP) models of AIDS are powerful systems for evaluating HIV vaccine approaches in vivo. Authentic features of HIV-1 transmission, dissemination, target cell tropism, and pathogenesis, and aspects of anti-HIV-1 immune responses, can be recapitulated in NHPs provided the appropriate, s...

journal_title：Current opinion in HIV and AIDS

authors： Del Prete GQ,Lifson JD,Keele BF

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:As understanding and integrating the structural and biomedical determinants of HIV infection is essential for the success of prevention efforts, there is a need for biomedical and social scientists to work together. RECENT FINDINGS:A review of the biomedical research literature indicates that the two...

journal_title：Current opinion in HIV and AIDS

authors： Kippax S

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...

journal_title：Current opinion in HIV and AIDS

authors： Mehandru S,Dandekar S

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

journal_title：Current opinion in HIV and AIDS

authors： Hall HI,Brooks JT,Mermin J

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...

journal_title：Current opinion in HIV and AIDS

authors： Boyer S,Koulla-Shiro S,Abé C,Spire B,Moatti JP

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...

journal_title：Current opinion in HIV and AIDS

authors： Clotet B,Paredes R

更新日期：2007-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed recent literature on the role of family planning in eliminating new pediatric HIV infections. RECENT FINDINGS:Global commitments to eliminate new pediatric HIV infections recognize that preventing unintended pregnancies among women with HIV is essential to achieving this goal. However, su...

journal_title：Current opinion in HIV and AIDS

authors： Wilcher R,Petruney T,Cates W

更新日期：2013-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...

journal_title：Current opinion in HIV and AIDS

authors： Kestens L,Seddiki N,Bohjanen PR

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burd...

journal_title：Current opinion in HIV and AIDS

authors： Althoff KN,Smit M,Reiss P,Justice AC

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The detrimental synergy of colliding HIV and tuberculosis (TB) epidemics is most devastating among children and adolescents living with HIV (CALWH) who shoulder a disproportionate burden of all child TB mortality. RECENT FINDINGS:CALWH benefit less from Bacille-Calmette Guerin vaccination than HIV-un...

journal_title：Current opinion in HIV and AIDS

authors： Kay A,Garcia-Prats AJ,Mandalakas AM

更新日期：2018-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...

journal_title：Current opinion in HIV and AIDS

authors： Richardson SI,Moore PL

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Long-acting injectable antiretroviral (ARV) formulations are being developed for the treatment and prevention of HIV infection. The purpose of this review is to summarize recent preclinical and clinical data on TMC278 (rilpivirine), a nonnucleoside reverse transcriptase inhibitor (NNRTI), that is bein...

journal_title：Current opinion in HIV and AIDS

authors： Jackson A,McGowan I

更新日期：2015-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent advances in the clinical care of HIV-infected children. RECENT FINDINGS:Obstacles to diagnosing HIV in children and providing clinical care to those HIV infected relate to a number of technical and operational factors. Most countries now have antiretroviral...

journal_title：Current opinion in HIV and AIDS

authors： Crowley S,Kekitiinwa A,Vaz P

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore the possible role of current prophylactic vaccines against human papillomavirus (HPV) in the prevention of anal intraepithelial neoplasia and squamous cell carcinoma of the anus (SCCA). RECENT FINDINGS:SCCA incidence is increasing in several developed countries, particularly in HIV-positiv...

journal_title：Current opinion in HIV and AIDS

authors： Franceschi S,De Vuyst H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemiology of HIV epidemics provides the roadmap for prioritization of programmes and serves over time to evaluate broadly the successes and challenges in prevention. The purpose of this review was to summarize recent information about the epidemiology of HIV in high-income countries with concen...

journal_title：Current opinion in HIV and AIDS

authors： Sullivan PS,Jones JS,Baral SD

更新日期：2014-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Approximately 150-175 million people are infected with hepatitis C virus (HCV). Until very recently, the complexity, cost and poor efficacy and tolerability of pegylated interferon and ribavirin (PEG-RBV) treatment have hindered scale up in low-income and middle-income countries (L&MICs). Similarly, t...

journal_title：Current opinion in HIV and AIDS

authors： Cohn J,Roberts T,Amorosa V,Lemoine M,Hill A

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...

journal_title：Current opinion in HIV and AIDS

authors： Evangeli M

更新日期：2018-05-01 00:00:00