HIV-1 replicative fitness in elite controllers.

abstract：PURPOSE OF REVIEW:The purpose is to review recent insights into the impact of HIV-associated immune activation on AIDS and non-AIDS morbidity and mortality. RECENT FINDINGS:Immune activation has long been recognized as an important consequence of untreated HIV infection and predictor of AIDS progression, which decline...

journal_title：Current opinion in HIV and AIDS

authors： Utay NS,Hunt PW

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the introduction of combined antiretroviral therapy (cART) and consequent reduction in the incidence of AIDS-related mortality, there has been a relative increase in the importance of non-AIDS-related conditions such as liver disease. This article reviews the positive and potential negative impac...

journal_title：Current opinion in HIV and AIDS

authors： Allen J,Smith C,Bhagani S

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...

journal_title：Current opinion in HIV and AIDS

authors： De Francesco D,Sabin CA,Reiss P

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:To discuss the role of mathematical models of sexual transmission of HIV: the methods used and their impact. RECENT FINDINGS:We use mathematical modelling of 'universal test and treat' as a case study to illustrate wider issues relevant to all modelling of sexual HIV transmission. SUMMARY:Mathematic...

journal_title：Current opinion in HIV and AIDS

authors： Baggaley RF,Fraser C

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the clinical features, pathogenesis and therapeutic options for the dyslipidaemia commonly seen in HIV-infected patients on combination antiretroviral therapy. RECENT FINDINGS:Dyslipidaemia associated with antiretroviral therapy is characterized by elevations in total and low-density lipo...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2007-07-01 00:00:00

abstract：PURPOSE OF REVIEW:T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and ho...

journal_title：Current opinion in HIV and AIDS

authors： Cubas R,Perreau M

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...

journal_title：Current opinion in HIV and AIDS

authors： Boyd MA

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Dendritic cells and their subsets are among the very first immune cells to tackle incoming pathogens and initiate innate and adaptive immune responses. During the past year, some studies investigating the early events occurring at mucosal sites, upon HIV infection, reinforced our view that the virus h...

journal_title：Current opinion in HIV and AIDS

authors： Blanchet F,Moris A,Mitchell JP,Piguet V

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:As understanding and integrating the structural and biomedical determinants of HIV infection is essential for the success of prevention efforts, there is a need for biomedical and social scientists to work together. RECENT FINDINGS:A review of the biomedical research literature indicates that the two...

journal_title：Current opinion in HIV and AIDS

authors： Kippax S

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

journal_title：Current opinion in HIV and AIDS

authors： Sacktor N,Robertson K

更新日期：2014-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...

journal_title：Current opinion in HIV and AIDS

authors： Alvarez E,Belloso WH,Boyd MA,Inkaya AÇ,Hsieh E,Kambugu A,Kaminski G,Martinez E,Stellbrink HJ,Walmsley S,Brown TT,Mallon PW

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...

journal_title：Current opinion in HIV and AIDS

authors： Andersen-Nissen E,Heit A,McElrath MJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update on the origin of the HIV epidemic and insights into how the immune response is shaping virus evolution. RECENT FINDINGS:Characterization of archival samples showed that by the 1960s, HIV had already diverged within humans. It is now estimated that HIV has been in humans since at ...

journal_title：Current opinion in HIV and AIDS

authors： Woodman Z,Williamson C

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...

journal_title：Current opinion in HIV and AIDS

authors： Reif LK,McNairy ML,Lamb MR,Fayorsey R,Elul B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...

journal_title：Current opinion in HIV and AIDS

authors： Grund B,Sabin C

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...

journal_title：Current opinion in HIV and AIDS

authors： Girard MP,Plotkin SA

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Here we present recent studies examining the gastrointestinal tract during primary HIV and simian immunodeficiency virus infections and emphasizing the onset of severe pathologic processes that are not adequately reflected in peripheral blood. We discuss these findings and hypotheses relating to the r...

journal_title：Current opinion in HIV and AIDS

authors： Mehandru S,Dandekar S

更新日期：2008-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...

journal_title：Current opinion in HIV and AIDS

authors： Kestens L,Seddiki N,Bohjanen PR

更新日期：2008-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To describe the causes, evaluation, and management of early virological failure in patients treated with their first antiretroviral regimen. RECENT FINDINGS:Combination antiretroviral therapy predictably induces a rapid virological response, with the majority of patients achieving an undetectable HIV...

journal_title：Current opinion in HIV and AIDS

authors： Sax PE

更新日期：2006-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blame...

journal_title：Current opinion in HIV and AIDS

authors： Moran CA,Weitzmann MN,Ofotokun I

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Adolescents with HIV include both those infected perinatally and behaviourally. This population is confronted by normative challenges and HIV stressors as they move towards becoming increasingly independent adults. This review focuses on mental health and substance use in adolescents with HIV. These a...

journal_title：Current opinion in HIV and AIDS

authors： Evangeli M

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The intricate balance between positive and negative signals delivered by accessory molecules is crucial to generate efficient immune responses while maintaining tolerance and preventing autoimmunity. Of these molecules, programmed death 1 has been described as a negative regulator of T-cell activation...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L,Said EA,Halwani R,Janbazian L,Chomont N,El-Far M,Breton G,Haddad EK,Sekaly RP

更新日期：2007-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Effective therapies have transformed HIV infection into a chronic disease, and new problems are arising related to aging. This article reviews the aging process, age-related deficit accumulation and frailty, and how these might be affected by chronic HIV infection. RECENT FINDINGS:Aging is characteri...

journal_title：Current opinion in HIV and AIDS

authors： Brothers TD,Rockwood K

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...

journal_title：Current opinion in HIV and AIDS

authors： Fox P

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The review addresses the role of dolutegravir (DTG) in first-line therapy. In the era of test and treat, where United Nations AIDS Program and WHO have set the ambitious targets of 90/90/90, new efficacious, well tolerated, and simple therapeutic options are needed. RECENT FINDINGS:DTG has been teste...

journal_title：Current opinion in HIV and AIDS

authors： Cahn P

更新日期：2017-07-01 00:00:00