HIV infection and immune activation: the role of coinfections.

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To examine kinetic issues related to the stability of the latent reservoir and the observation of low levels of viremia (< 50 copies/ml) in patients treated with highly active antiretroviral therapy. RECENT FINDINGS:Once HIV-1 RNA becomes undetectable it is difficult to deduce the events occurring in...

journal_title：Current opinion in HIV and AIDS

authors： Kim H,Perelson AS

更新日期：2006-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...

journal_title：Current opinion in HIV and AIDS

authors： Boyd MA

更新日期：2009-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

journal_title：Current opinion in HIV and AIDS

authors： Trautmann L

更新日期：2016-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is establi...

journal_title：Current opinion in HIV and AIDS

authors： Tomaras GD,Haynes BF

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...

journal_title：Current opinion in HIV and AIDS

authors： El-Bassel N,Wechsberg WM,Shaw SA

更新日期：2012-07-01 00:00:00

abstract：PURPOSE OF REVIEW:In this review, the roles of Fc-gamma receptor polymorphisms are discussed in regards to HIV-1 vaccine efficacy, HIV acquisition, and disease progression. In addition, the significance of the neonatal immunoglobulin G (IgG) Fc receptor and potential effects of the aggregated immunoglobulin A Fc recept...

journal_title：Current opinion in HIV and AIDS

authors： Cocklin SL,Schmitz JE

更新日期：2014-05-01 00:00:00

abstract：PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...

journal_title：Current opinion in HIV and AIDS

authors： Davies MA,Gibb D,Turkova A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Despite significant technical advances that have permitted an increasingly more quantitative and detailed study of virus-specific cellular immunity over the past few years, our understanding of the nature of immunological control in rare cases of non-progressive HIV infection and diminished control in...

journal_title：Current opinion in HIV and AIDS

authors： Migueles SA,Tilton JC,Connors M

更新日期：2006-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Research directed toward an HIV cure presents ethical as well as scientific challenges. RECENT FINDINGS:International guidelines, regulations, and the medical literature provide helpful guidance on protecting research participants. SUMMARY:This review presents points to consider for researchers, spo...

journal_title：Current opinion in HIV and AIDS

authors： Lo B,Grady C,Working Group on Ethics of the International AIDS Society.

更新日期：2013-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The aim of this article is to review recent advances in the clinical care of HIV-infected children. RECENT FINDINGS:Obstacles to diagnosing HIV in children and providing clinical care to those HIV infected relate to a number of technical and operational factors. Most countries now have antiretroviral...

journal_title：Current opinion in HIV and AIDS

authors： Crowley S,Kekitiinwa A,Vaz P

更新日期：2007-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent findings pertaining to the public health impact of schistosomiasis on the epidemiology of HIV/AIDS are summarized. RECENT FINDINGS:Both empiric data and mathematical models support the hypothesis that schistosome infections lead to increased susceptibility to infection with HIV-1, a more r...

journal_title：Current opinion in HIV and AIDS

authors： Secor WE

更新日期：2012-05-01 00:00:00

abstract：PURPOSE OF REVIEW:The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. This review will outline the current epidemiology of HCV in HIV infection, focusing on the recent changes and factors which have been related to the increase in HCV transmission in HIV-infected men who h...

journal_title：Current opinion in HIV and AIDS

authors： Danta M,Rodger AJ

更新日期：2011-11-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

journal_title：Current opinion in HIV and AIDS

authors： Mayne ES,George JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...

journal_title：Current opinion in HIV and AIDS

authors： Sereti I,Rodger AJ,French MA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...

journal_title：Current opinion in HIV and AIDS

authors： Wu L

更新日期：2008-09-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review is to examine the literature regarding HIV-associated neurocognitive disorders, early HIV infection of the central nervous system (CNS), the role of the peripheral immune system in controlling HIV infection and disease within the brain and the potential role that early antir...

journal_title：Current opinion in HIV and AIDS

authors： Wright EJ

更新日期：2009-09-01 00:00:00

abstract：PURPOSE OF REVIEW:To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract. RECENT FINDINGS:Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentration...

journal_title：Current opinion in HIV and AIDS

authors： Taylor S,Davies S

更新日期：2010-07-01 00:00:00

abstract：PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...

journal_title：Current opinion in HIV and AIDS

authors： Heeney JL

更新日期：2006-07-01 00:00:00

abstract：OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...

journal_title：Current opinion in HIV and AIDS

authors： Shahid S,Majeed MF,Awaan AB,Mirza H,Sarfraz N,Veronese V

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:A major focus in HIV vaccine research is the development of suitable antigens that elicit broadly neutralizing antibody responses targeting HIV's envelope protein (Env). Delivery of Env in a repetitive manner on particle-based carriers allows higher avidity interactions and is therefore expected to ef...

journal_title：Current opinion in HIV and AIDS

authors： Asbach B,Wagner R

更新日期：2017-05-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...

journal_title：Current opinion in HIV and AIDS

authors： Girard MP,Plotkin SA

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:This article discusses the interaction between HIV infection, the gut microbiome, inflammation and immune activation, and HIV reservoirs, along with interventions to target the microbiome and their implications for HIV remission and cure. RECENT FINDINGS:Most studies show that HIV-infected adults hav...

journal_title：Current opinion in HIV and AIDS

authors： Koay WLA,Siems LV,Persaud D

更新日期：2018-01-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

journal_title：Current opinion in HIV and AIDS

authors： Southwell M,Shelly S,MacDonald V,Verster A,Maher L

更新日期：2019-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV functional cure requires the elimination or a major reduction of HIV reservoir pool including male and female genital HIV reservoirs. A comprehensive understanding of HIV dynamics in these compartments is mandatory. RECENT FINDINGS:Data from chronically HIV-infected therapy-naïve individuals or f...

journal_title：Current opinion in HIV and AIDS

authors： Gantner P,Ghosn J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...

journal_title：Current opinion in HIV and AIDS

authors： Van Tieu H,Koblin BA

更新日期：2009-07-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV's primary site of infection is at mucosal surfaces. To successfully defend against sexually transmitted diseases (STDs), including HIV, protection may need to be specifically elicited at the mucosal interface, where the organism enters the host. Recent advances in measuring adaptive responses at m...

journal_title：Current opinion in HIV and AIDS

authors： Duerr A

更新日期：2010-09-01 00:00:00