Abstract:
PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic liver transplantation in this population compared with the HIV-negative population. RECENT FINDINGS:Many studies have described epidemiological aspects, including the increasing incidence of end-stage liver disease, as a cause of non-AIDS-related death in the co-infected population in developed countries, whereas other reports have focused on the clinical presentation and prognosis of end-stage liver disease in this specific clinical setting. The medical management of end-stage liver disease should be the same as for the HIV-negative population, and orthotopic liver transplantation is the only therapeutic option for HIV-infected patients who are eligible for this procedure. SUMMARY:End-stage liver disease is becoming a major issue in the HIV/HCV-coinfected population because of its increasing frequency, especially now the prognosis of HIV infection has improved with combined antiretroviral therapy. Medical management is essential and should be considered a bridge to orthotopic liver transplantation. Nevertheless, many issues remain unclear and must be examined in further studies.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Agüero F,Laguno M,Moreno A,Rimola A,Miró JM,Hospital Clinic OLT in HIV Working Group.doi
10.1097/COH.0b013e3282f0aaddsubject
Has Abstractpub_date
2007-11-01 00:00:00pages
474-81issue
6eissn
1746-630Xissn
1746-6318pii
01222929-200711000-00006journal_volume
2pub_type
杂志文章abstract:PURPOSE OF REVIEW:Modern interferon (IFN)-free, and potentially also ribavirin-free, combinations consisting of two or three direct-acting antivirals (DAAs) are highly efficacious in treating chronic hepatitis C virus (HCV) infection with treatment durations being much shorter and with much more favorable toxicity prof...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000181
更新日期:2015-09-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000342
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review discusses the use of the inhibitory quotient in light of therapeutic drug monitoring of antiretroviral drugs. The inhibitory quotient is a parameter that combines viral resistance data with drug exposure data, and has its main role in therapeutic drug monitoring of protease inhibitors in e...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282fbaaba
更新日期:2008-05-01 00:00:00
abstract:PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000241
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000401
更新日期:2017-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000578
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000661
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Small molecule inhibitors targeting the CCR5 coreceptor represent a new class of drugs for treating HIV-1 infection. Maraviroc has received regulatory approvals, and vicriviroc is in phase 3 trials. Understanding how resistance to these drugs develops and is diagnosed is essential to guide clinical pr...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283223d46
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burd...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000305
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the risk of cardiovascular complications in HIV-infected patients receiving combination antiretroviral treatment. RECENT FINDINGS:Recent data suggest that patients with chronic HIV infection will require continuous lifelong combination antiretroviral treatment, which may increase the risk o...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000247389.08485.87
更新日期:2006-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review the most recent literature regarding the immunopathogenesis of pathogen-associated immune reconstitution disease and to discuss the role of immune activation and various effector molecules and cells such as macrophages, effector and regulatory T cells, and natural ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328302ebbb
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:As understanding and integrating the structural and biomedical determinants of HIV infection is essential for the success of prevention efforts, there is a need for biomedical and social scientists to work together. RECENT FINDINGS:A review of the biomedical research literature indicates that the two...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32830136a0
更新日期:2008-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000197
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000071
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most inte...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328331b526
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review the status of HIV vaccine development RECENT FINDINGS:Since the discovery of HIV-1 in the early 1980s considerable effort has been exerted to develop a prophylactic vaccine, with relatively meagre results. The absence of natural immunity has proven to be a major stumbling block in identifyi...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32834ddc96
更新日期:2012-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000554
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833860ba
更新日期:2010-05-01 00:00:00
abstract:PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000303
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000566
更新日期:2019-09-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000102
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328363d389
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000080
更新日期:2014-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current data on HIV-1 resistance arising from the use of fixed dose combination tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) for preexposure prophylaxis (PrEP) to prevent HIV-1 infection. RECENT FINDINGS:Resistance to tenofovir (TNV) or FTC is infrequently selected by TDF/FTC PrEP ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000209
更新日期:2016-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833ed774
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this article is to review recent advances in the clinical care of HIV-infected children. RECENT FINDINGS:Obstacles to diagnosing HIV in children and providing clinical care to those HIV infected relate to a number of technical and operational factors. Most countries now have antiretroviral...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282ddedf5
更新日期:2007-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Here we highlight the latest advances in HIV vaccine concepts that will expand our knowledge on how to elicit effective acquisition-prevention and/or control of simian immunodeficiency virus (SIV) replication in the nonhuman primate (NHP) model. RECENT FINDINGS:In the context of the promising analyse...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328361cfe8
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Differential rates of disease progression are obviously multifactorial, but the virulence of the actual infecting virus is most frequently ignored as potential source of slow or rapid disease progression. In this review, the argument will be made that nearly all elite suppressors are infected by weak ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283454cf5
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833ed742
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research an...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000616
更新日期:2020-05-01 00:00:00