Early antiretroviral therapy mortality in resource-limited settings: what can we do about it?

abstract：PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...

journal_title：Current opinion in HIV and AIDS

authors： Scully EP

更新日期：2021-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Osteoporosis remains an important focus of contemporary research in HIV, with co-morbidities and mortality from non-AIDS illnesses now a major barrier to normal lifespan in many populations living with HIV. This review outlines the major recent advances in our understanding of osteoporosis and fractur...

journal_title：Current opinion in HIV and AIDS

authors： Mallon PW

更新日期：2014-07-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV functional cure requires the elimination or a major reduction of HIV reservoir pool including male and female genital HIV reservoirs. A comprehensive understanding of HIV dynamics in these compartments is mandatory. RECENT FINDINGS:Data from chronically HIV-infected therapy-naïve individuals or f...

journal_title：Current opinion in HIV and AIDS

authors： Gantner P,Ghosn J

更新日期：2018-09-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

journal_title：Current opinion in HIV and AIDS

authors： Mayne ES,George JA

更新日期：2017-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

journal_title：Current opinion in HIV and AIDS

authors： Rajasuriar R,Wright E,Lewin SR

更新日期：2015-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most inte...

journal_title：Current opinion in HIV and AIDS

authors： Koelsch KK,Cooper DA

更新日期：2009-11-01 00:00:00

abstract：PURPOSE OF REVIEW:We describe recent mobile health (mHealth) interventions supporting antiretroviral therapy (ART) medication adherence among HIV-positive MSM. RECENT FINDINGS:Keyword searches (1 January 2016-13 May 2017) identified 721 citations. Seven publications reporting on six studies met inclusion criteria. Fiv...

journal_title：Current opinion in HIV and AIDS

authors： Muessig KE,LeGrand S,Horvath KJ,Bauermeister JA,Hightow-Weidman LB

更新日期：2017-09-01 00:00:00

abstract：PURPOSE OF REVIEW:With the large international mobilization against HIV/AIDS, more HIV-infected people in resource-limited settings have access to antiretroviral therapy, including pregnant women. The relevance of simplified prophylactic antiretroviral regimens for the prevention of mother-to-child transmission of HIV ...

journal_title：Current opinion in HIV and AIDS

authors： Arrivé E,Dabis F

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:This article explores new data from recent studies addressing the role of coinfections in immune activation in HIV-1-infected patients, with a focus on immune reconstitution inflammatory syndrome (IRIS), an aberrant inflammatory response occurring shortly after antiretroviral therapy (ART) initiation....

journal_title：Current opinion in HIV and AIDS

authors： Boulougoura A,Sereti I

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

journal_title：Current opinion in HIV and AIDS

authors： Moris A,Pereira M,Chakrabarti L

更新日期：2019-07-01 00:00:00

abstract：PURPOSE OF REVIEW:With the progressive aging of populations of people with HIV (PWH), multimorbidity is increasing. Multimorbidity patterns, that is groups of comorbidities that are likely to co-occur, may suggest shared causes or common risk factors. We review the literature regarding multimorbidity patterns identifie...

journal_title：Current opinion in HIV and AIDS

authors： De Francesco D,Sabin CA,Reiss P

更新日期：2020-03-01 00:00:00

abstract：PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...

journal_title：Current opinion in HIV and AIDS

authors： Andersen-Nissen E,Heit A,McElrath MJ

更新日期：2012-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cancer, but no...

journal_title：Current opinion in HIV and AIDS

authors： Bernstein WB,Dennis PA

更新日期：2008-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Significant gastrointestinal pathology occurs in progressive HIV and simian immunodeficiency virus (SIV) infections. This review will examine the relationship between the detrimental events to the gastrointestinal tract during the acute phase of infection and disease progression through the chronic ph...

journal_title：Current opinion in HIV and AIDS

authors： Brenchley JM,Douek DC

更新日期：2008-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides international insights into the real-world clinical approach to screening for bone mineral density (BMD) and osteoporosis in people living with HIV (PLWH) using opinions from HIV physicians from key regions around the world. RECENT FINDINGS:Although a significant proportion of PL...

journal_title：Current opinion in HIV and AIDS

authors： Alvarez E,Belloso WH,Boyd MA,Inkaya AÇ,Hsieh E,Kambugu A,Kaminski G,Martinez E,Stellbrink HJ,Walmsley S,Brown TT,Mallon PW

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and ho...

journal_title：Current opinion in HIV and AIDS

authors： Cubas R,Perreau M

更新日期：2014-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Modern interferon (IFN)-free, and potentially also ribavirin-free, combinations consisting of two or three direct-acting antivirals (DAAs) are highly efficacious in treating chronic hepatitis C virus (HCV) infection with treatment durations being much shorter and with much more favorable toxicity prof...

journal_title：Current opinion in HIV and AIDS

authors： Boesecke C,Page E

更新日期：2015-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Many of the almost 2 million HIV infections that occurred globally in the last year occurred among adolescents and young people, particularly those from East and Southern Africa and within key populations. Global HIV epidemic control will require that new infections among these youth populations be cu...

journal_title：Current opinion in HIV and AIDS

authors： Pettifor A,Stoner M,Pike C,Bekker LG

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Outcomes among young people living with HIV (YPLWH) remain disturbingly poor. We summarize recent research on youth-friendly services (YFS) and adolescent-specific differentiated care models, which may improve outcomes across the HIV care continuum for this vulnerable population. We further emphasize ...

journal_title：Current opinion in HIV and AIDS

authors： Reif LK,McNairy ML,Lamb MR,Fayorsey R,Elul B

更新日期：2018-05-01 00:00:00

abstract：PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...

journal_title：Current opinion in HIV and AIDS

authors： Okulicz JF,Lambotte O

更新日期：2011-05-01 00:00:00

abstract：PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

journal_title：Current opinion in HIV and AIDS

authors： Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

更新日期：2013-01-01 00:00:00

abstract：PURPOSE OF REVIEW:HIV infection is an established risk factor for osteoporosis and bone fracture. Combination antiretroviral therapy (cART) increases bone resorption leading to an additional 2-6% bone mineral density (BMD) loss within the first 1-2 years of therapy. Although tenofovir disoproxil fumarate is often blame...

journal_title：Current opinion in HIV and AIDS

authors： Moran CA,Weitzmann MN,Ofotokun I

更新日期：2016-05-01 00:00:00

abstract：PURPOSE OF REVIEW:It is 20 years since the start of the combination antiretroviral therapy (cART) era and more than 10 years since cART scale-up began in resource-limited settings. We examined survival of vertically HIV-infected infants and children in the cART era. RECENT FINDINGS:Good survival has been achieved on c...

journal_title：Current opinion in HIV and AIDS

authors： Davies MA,Gibb D,Turkova A

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...

journal_title：Current opinion in HIV and AIDS

authors： Boyer S,Koulla-Shiro S,Abé C,Spire B,Moatti JP

更新日期：2011-07-01 00:00:00

abstract：PURPOSE OF REVIEW:To explore the possible role of current prophylactic vaccines against human papillomavirus (HPV) in the prevention of anal intraepithelial neoplasia and squamous cell carcinoma of the anus (SCCA). RECENT FINDINGS:SCCA incidence is increasing in several developed countries, particularly in HIV-positiv...

journal_title：Current opinion in HIV and AIDS

authors： Franceschi S,De Vuyst H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Immune reconstitution inflammatory syndrome (IRIS) is the paradoxical worsening or unmasking of an infection or neoplasm in HIV-1-infected patients shortly after antiretroviral therapy (ART) initiation. New insights into the pathogenesis of IRIS may help identify biomarkers that could be useful in pre...

journal_title：Current opinion in HIV and AIDS

authors： Sereti I,Rodger AJ,French MA

更新日期：2010-11-01 00:00:00

abstract：PURPOSE OF REVIEW:In the next 5-10 years, neither antiviral drug treatment nor a preventive vaccine is expected to provide a solution to the HIV epidemic. To achieve a relevant public health benefit, it is time to change focus and develop immune therapies to achieve a beneficial viral load reduction in the absence of d...

journal_title：Current opinion in HIV and AIDS

authors： Lisziewicz J

更新日期：2008-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

journal_title：Current opinion in HIV and AIDS

authors： Essex M,Makhema J,Lockman S

更新日期：2019-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Natural killer (NK) cells promote antiviral immunity by producing proinflammatory cytokines and by lysing infected cells. In addition, NK cells can modulate dendritic cell functions. NK-dendritic cell crosstalk results in activation of both cell types, with dendritic cells promoting NK-cell activity a...

journal_title：Current opinion in HIV and AIDS

authors： Gougeon ML,Bras M

更新日期：2011-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

journal_title：Current opinion in HIV and AIDS

authors： Sabin KM,Johnston LG

更新日期：2014-03-01 00:00:00