Abstract:
PURPOSE OF REVIEW:The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. This review will outline the current epidemiology of HCV in HIV infection, focusing on the recent changes and factors which have been related to the increase in HCV transmission in HIV-infected men who have sex with men (MSM). RECENT FINDINGS:Since 2000 there has been recognition in the postindustrialized world that there has been a dramatic rise in the incidence of HCV in HIV-infected MSM. Whereas sexual transmission of HCV remains controversial in the general population, there is increasing evidence that permucosal (sexual and mucosally administered drugs) rather than parenteral risks have become key factors in HCV transmission in HIV-infected MSM. At the most basic level, transmission depends on disruption of a barrier and exposure to infected fluids, usually blood. Whereas transmission factors are often closely entwined, they can be characterized as behavioural and biological factors. SUMMARY:With an improved understanding of the epidemiology of HCV in this population, interventions by relevant health authorities could be better focused.
journal_name
Curr Opin HIV AIDSjournal_title
Current opinion in HIV and AIDSauthors
Danta M,Rodger AJdoi
10.1097/COH.0b013e32834b4974subject
Has Abstractpub_date
2011-11-01 00:00:00pages
451-8issue
6eissn
1746-630Xissn
1746-6318pii
01222929-201111000-00003journal_volume
6pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000193
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To briefly describe some of the replication-competent vectors being investigated for development of candidate HIV vaccines focusing primarily on technologies that have advanced to testing in macaques or have entered clinical trials. RECENT FINDINGS:Replication-competent viral vectors have advanced to...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328363d389
更新日期:2013-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The aim of this review was to compare and contrast the application of molecular epidemiology approaches for the improved management and understanding of the HIV versus SARS-CoV-2 epidemics. RECENT FINDINGS:Molecular biology approaches, including PCR and whole genome sequencing (WGS), have become powe...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000660
更新日期:2021-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Given the lack of evidence on how to best design and implement antiretroviral therapy (ART) scaling-up policies, operational research has seen a surge in interest. There is, however, little published information on the contribution of operational research in ART programs' implementation or in improvem...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283478757
更新日期:2011-07-01 00:00:00
abstract:PURPOSE OF REVIEW:This review provides information on the natural history of end-stage liver disease in HIV/hepatitis C virus-coinfected patients from diagnosis to liver transplantation or death and summarizes recent developments in the epidemiology, management, and prognosis of end-stage liver disease and orthotopic l...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e3282f0aadd
更新日期:2007-11-01 00:00:00
abstract:PURPOSE OF REVIEW:For the first time in decades, there are multiple new drugs in the pipeline for the treatment of tuberculosis (TB). In addition, existing drugs are being repurposed or optimized for TB with the goal of shortened treatment duration for drug-sensitive TB and safer, shorter treatments for multidrug-resis...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000009
更新日期:2013-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Despite significant technical advances that have permitted an increasingly more quantitative and detailed study of virus-specific cellular immunity over the past few years, our understanding of the nature of immunological control in rare cases of non-progressive HIV infection and diminished control in...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/01.COH.0000194108.14601.69
更新日期:2006-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Early studies have cast doubt on the utility of animal models for predicting success or failure of HIV-prevention strategies, but results of multiple human phase 3 microbicide trials, and interrogations into the discrepancies between human and animal model trials, indicate that animal models were, and...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328361d096
更新日期:2013-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32832aa902
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:To explore the utility of home and community-based HIV testing and counseling (HTC) to increase detection of undiagnosed HIV among female spouses and children of HIV-positive PWID in Punjab province, Pakistan. DESIGN:Between March 2014 and March 2015, home-based HTC was provided by a local NGO to spouses of...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0000000000000263
更新日期:2016-03-01 00:00:00
abstract:PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000102
更新日期:2014-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To examine the literature in search of data supporting (stopping highly active antiretroviral therapy (HAART) temporarily in the absence of virus rebound) to expand HIV treatment options. RECENT FINDINGS:We proposed investigating HAART interruptions after the 'Berlin patient' had discontinued HAART w...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328011aad6
更新日期:2007-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The introduction of combination antiretroviral therapy (cART) led to substantial reductions in HIV-associated morbidity and mortality. However, the regimens in the early cART era were cumbersome and toxic. The introduction of new ART agents, fixed-dose combinations and novel strategies for cART delive...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328329fc8d
更新日期:2009-05-01 00:00:00
abstract:PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e32833ed742
更新日期:2010-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight promising areas of research and preview future generations of microbicides, this review will focus on reports that described new cellular or viral targets, drug substances, or strategies that are specifically intended for topical microbicides. Those reports that dealt with the design, dis...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32830ab9dd
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Knowledge of HIV status is the gateway to HIV treatment and prevention, and optimizing this pillar is essential to bend the curve of the HIV epidemic toward zero new infections. This review will discuss the epidemiology of serostatus awareness, including disparities among key populations, and explore ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000590
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:It is generally accepted that a high degree of adherence to the dosing regimens of protease inhibitors is essential to avoid virological failure. It is also believed that once-daily dosing of protease inhibitors, by improving adherence, will lead to better outcomes. This review will discuss the patter...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32831271c2
更新日期:2008-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To determine whether current evidence and expert opinion support the routine use of anal cytology and high-resolution anoscopy in men who have sex with men. RECENT FINDINGS:Most recently published guidelines do not recommend routine anal cytology, but anal cancer is undoubtedly a serious and growing ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/coh.0b013e32831a6fe0
更新日期:2009-01-01 00:00:00
abstract:PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000197
更新日期:2015-11-01 00:00:00
abstract:PURPOSE OF REVIEW:To review current knowledge and the role of integrase inhibitors in the setting of HIV salvage therapy. We will discuss results from recent studies and literature and comment on the potential for integrase inhibitors in defined clinical settings. RECENT FINDINGS:Raltegravir has been studied most inte...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328331b526
更新日期:2009-11-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to summarize data in the last 18 months on the sexual and reproductive health of perinatally and horizontally infected adolescents and young people living with HIV (age 13-25 years) and to highlight some key issues faced by this group of adolescents as they reach puberty and sexual de...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000456
更新日期:2018-05-01 00:00:00
abstract:PURPOSE OF REVIEW:T follicular helper (Tfh) cells play a critical role as providers of B-cell help and dysfunction in Tfh/B-cell interactions can lead to autoimmunity or immunodeficiency. These observations have generated a great deal of interest in understanding how these cells are affected during HIV infection and ho...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000095
更新日期:2014-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Small molecule inhibitors targeting the CCR5 coreceptor represent a new class of drugs for treating HIV-1 infection. Maraviroc has received regulatory approvals, and vicriviroc is in phase 3 trials. Understanding how resistance to these drugs develops and is diagnosed is essential to guide clinical pr...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e3283223d46
更新日期:2009-03-01 00:00:00
abstract:PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32830634c6
更新日期:2008-09-01 00:00:00
abstract:PURPOSE OF REVIEW:The body of knowledge regarding antiretroviral drug resistance is rapidly evolving as a result of extensive research and the continuous availability of new antiretroviral drugs. The interpretation of drug resistance tests may be difficult for clinicians not working in highly specialized healthcare env...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e32801470f6
更新日期:2007-03-01 00:00:00
abstract:PURPOSE OF REVIEW:It has been demonstrated that extensive virus diversification and antibody coevolution are necessary to give rise to broadly neutralizing antibodies targeting the envelope protein of HIV-1. Here, we discuss recent progress of vaccine design approaches aiming on strategies to initiate and guide B-cell ...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000356
更新日期:2017-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000580
更新日期:2019-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Recent studies have been published characterizing the epidemiology of elite controllers. The demographic features, clinical characteristics, and HIV disease outcomes of elite controllers are summarized. RECENT FINDINGS:Elite controllers are defined by the ability to spontaneously suppress plasma vire...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0b013e328344f35e
更新日期:2011-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Although the goal of preventive HIV vaccine design is primarily the induction of broadly neutralizing antibodies (bNAbs), recent evidence suggests that a protective response will also benefit from Fc effector functions. Here, we provide an update on the antibody response to HIV infection, including bo...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章,评审
doi:10.1097/COH.0000000000000559
更新日期:2019-07-01 00:00:00
abstract:PURPOSE OF REVIEW:Although designed to target only the HIV protease, HIV protease inhibitors induce toxicities in patients such as insulin resistance and lipodystrophy that suggest that protease inhibitors have other targets in mammalian cells. Akt controls insulin signaling and is an important target in cancer, but no...
journal_title:Current opinion in HIV and AIDS
pub_type: 杂志文章
doi:10.1097/COH.0b013e328313915d
更新日期:2008-11-01 00:00:00