Transmission of HCV in HIV-positive populations.


PURPOSE OF REVIEW:The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. This review will outline the current epidemiology of HCV in HIV infection, focusing on the recent changes and factors which have been related to the increase in HCV transmission in HIV-infected men who have sex with men (MSM). RECENT FINDINGS:Since 2000 there has been recognition in the postindustrialized world that there has been a dramatic rise in the incidence of HCV in HIV-infected MSM. Whereas sexual transmission of HCV remains controversial in the general population, there is increasing evidence that permucosal (sexual and mucosally administered drugs) rather than parenteral risks have become key factors in HCV transmission in HIV-infected MSM. At the most basic level, transmission depends on disruption of a barrier and exposure to infected fluids, usually blood. Whereas transmission factors are often closely entwined, they can be characterized as behavioural and biological factors. SUMMARY:With an improved understanding of the epidemiology of HCV in this population, interventions by relevant health authorities could be better focused.


Curr Opin HIV AIDS


Danta M,Rodger AJ




Has Abstract


2011-11-01 00:00:00














  • The HIV treatment cascade in acutely infected people: informing global guidelines.

    abstract:PURPOSE OF REVIEW:Acute and early HIV (AHI) is a pivotal time during HIV infection, yet there remain major shortfalls in diagnosis, linkage to care, and antiretroviral therapy (ART) initiation during AHI. We introduce an AHI-specific cascade, review recent evidence pertaining to the unique challenges of AHI, and discus...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Rutstein SE,Sellers CJ,Ananworanich J,Cohen MS

    更新日期:2015-11-01 00:00:00

  • Dual HIV risk and vulnerabilities among women who use or inject drugs: no single prevention strategy is the answer.

    abstract:PURPOSE OF REVIEW:This article examines the dual HIV and sexually transmitted infection (STI) risk behaviors engaged in by women who use or inject drugs; the individual, social, and structural drivers of HIV and STI risk; prevention strategies; and the implications for multilevel, combined, sex-specific HIV prevention ...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: El-Bassel N,Wechsberg WM,Shaw SA

    更新日期:2012-07-01 00:00:00

  • More than osteoporosis: age-specific issues in bone health.

    abstract:PURPOSE OF REVIEW:The interaction between fall and fracture risk factors is an area of increasing clinical relevance, but little information is known about the age-specific issues in bone health unique to HIV-infected adults. The present review will focus on what is known about falls and fall risk factors among HIV-inf...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Erlandson KM,Guaraldi G,Falutz J

    更新日期:2016-05-01 00:00:00

  • Profiling immunity to HIV vaccines with systems biology.

    abstract:PURPOSE OF REVIEW:The recent modest success of the RV144 HIV vaccine trial in Thailand has shown that development of an HIV vaccine is possible. Designing a vaccine that achieves better protection, however, will require a more complete understanding of vaccine mechanisms of action and correlates of protection. Systems ...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Andersen-Nissen E,Heit A,McElrath MJ

    更新日期:2012-01-01 00:00:00

  • HIV-1-specific antibody responses during acute and chronic HIV-1 infection.

    abstract:PURPOSE OF REVIEW:The humoral immune response to HIV-1 throughout infection is comprised of complex mixtures of antibody isotypes with numerous HIV-1 specificities. However, unlike antibody responses to most infections, protective antibody responses are delayed and do not arise until long after HIV-1 latency is establi...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Tomaras GD,Haynes BF

    更新日期:2009-09-01 00:00:00

  • Recent developments with advancing gene therapy to treat chronic infection with hepatitis B virus.

    abstract:PURPOSE OF REVIEW:The available vaccine and therapies against hepatitis B virus (HBV) rarely eliminate chronic infection with the virus. High mortality resulting from complicating cirrhosis and hepatocellular carcinoma makes improving anti-HBV therapy an important priority. Recent advances with using gene therapy to co...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章


    authors: Maepa MB,Jacobs R,van den Berg F,Arbuthnot P

    更新日期:2020-05-01 00:00:00

  • Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?

    abstract:PURPOSE OF REVIEW:Natural killer (NK) cells promote antiviral immunity by producing proinflammatory cytokines and by lysing infected cells. In addition, NK cells can modulate dendritic cell functions. NK-dendritic cell crosstalk results in activation of both cell types, with dendritic cells promoting NK-cell activity a...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Gougeon ML,Bras M

    更新日期:2011-09-01 00:00:00

  • A pièce de resistance: how HIV-1 escapes small molecule CCR5 inhibitors.

    abstract:PURPOSE OF REVIEW:Small molecule inhibitors targeting the CCR5 coreceptor represent a new class of drugs for treating HIV-1 infection. Maraviroc has received regulatory approvals, and vicriviroc is in phase 3 trials. Understanding how resistance to these drugs develops and is diagnosed is essential to guide clinical pr...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Moore JP,Kuritzkes DR

    更新日期:2009-03-01 00:00:00

  • Analysis of biomarker data: logs, odds ratios, and receiver operating characteristic curves.

    abstract:PURPOSE OF REVIEW:We discuss two data analysis issues for studies that use binary clinical outcomes (whether or not an event occurred): the choice of an appropriate scale and transformation when biomarkers are evaluated as explanatory factors in logistic regression and assessing the ability of biomarkers to improve pre...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Grund B,Sabin C

    更新日期:2010-11-01 00:00:00

  • Preclinical primate studies of HIV-1-envelope-based vaccines: towards human clinical trials.

    abstract:PURPOSE OF REVIEW:There is growing debate on how nonhuman primate models of AIDS can best guide and facilitate clinical development of HIV vaccines. This review covers the simian/human immunodeficiency virus primate model and its strategic use in guiding the development and selection of HIV-1-envelope-based vaccine can...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章


    authors: Heeney JL

    更新日期:2006-07-01 00:00:00

  • Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage.

    abstract:PURPOSE OF REVIEW:The purpose of this review was to summarize recent studies on the effect of early antiretroviral therapy (ART) in HIV-infected patients on markers of immune activation/inflammation, viral persistence and serious non-AIDS events. RECENT FINDINGS:Early ART, initiated within days to months of HIV infect...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Rajasuriar R,Wright E,Lewin SR

    更新日期:2015-01-01 00:00:00

  • Reaching 90-90-90 in Botswana.

    abstract:PURPOSE OF REVIEW:Botswana, a small country in southern Africa, has had a very high prevalence of HIV since about 1995. It seems important to analyze the response of this country to help us understand how it became one of the first nations to achieve the 90-90-90 targets. RECENT FINDINGS:Botswana began a national prog...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Essex M,Makhema J,Lockman S

    更新日期:2019-11-01 00:00:00

  • Kill: boosting HIV-specific immune responses.

    abstract:PURPOSE OF REVIEW:Increasing evidence suggests that purging the latent HIV reservoir in virally suppressed individuals will require both the induction of viral replication from its latent state and the elimination of these reactivated HIV-infected cells ('Shock and Kill' strategy). Boosting potent HIV-specific CD8 T ce...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Trautmann L

    更新日期:2016-07-01 00:00:00

  • Hidden in plain sight: sex and gender in global pandemics.

    abstract:PURPOSE OF REVIEW:The global pandemic caused by the severe acute respiratory virus coronavirus 2 (SARS-CoV-2) has a male bias in mortality likely driven by both gender and sex-based differences between male and female individuals. This is consistent with sex and gender-based features of HIV infection and overlap betwee...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Scully EP

    更新日期:2021-01-01 00:00:00

  • Epidemiological challenges to the assessment of HIV burdens among key populations: respondent-driven sampling, time-location sampling and demographic and health surveys.

    abstract:PURPOSE OF REVIEW:Measuring the burden of HIV among key populations is subject to many challenges. Sufficient quantities of valid HIV prevalence and programme coverage data are required to effectively respond to the epidemic. RECENT FINDINGS:Ability to validate exposure to unprotected sex through the innovative use of...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Sabin KM,Johnston LG

    更新日期:2014-03-01 00:00:00

  • A role for antibodies in natural HIV control.

    abstract:PURPOSE OF REVIEW:Rare patients naturally control HIV replication without antiretroviral therapy. Understanding the mechanisms implicated in natural HIV control will inform the development of immunotherapies against HIV. Elite controllers are known for developing efficient antiviral T-cell responses, but recent finding...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Moris A,Pereira M,Chakrabarti L

    更新日期:2019-07-01 00:00:00

  • Antiretroviral therapy adherence and retention in care in middle-income and low-income countries: current status of knowledge and research priorities.

    abstract:PURPOSE OF REVIEW:Adherence to combination antiretroviral therapy (cART) is one of the most important contributing factors to positive clinical outcomes in patients with HIV, and long-term retention of patients in low-income and middle-income countries is emerging as an important issue in rapidly expanding cART program...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Nachega JB,Mills EJ,Schechter M

    更新日期:2010-01-01 00:00:00

  • Soaring antiretroviral prices, TRIPS and TRIPS flexibilities: a burning issue for antiretroviral treatment scale-up in developing countries.

    abstract:PURPOSE OF REVIEW:The achievement of significant reductions in the price of antiretroviral drugs constitutes one of the main economic pillars of antiretroviral treatment scale-up in developing countries. Today this economic pillar is threatened. RECENT FINDINGS:The prohibitive prices of newer first-line and second-lin...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Orsi F,d'almeida C

    更新日期:2010-05-01 00:00:00

  • HIV treatment cascade in tuberculosis patients.

    abstract:PURPOSE OF REVIEW:Globally, the number of deaths associated with tuberculosis (TB) and HIV coinfection remains unacceptably high. We review the evidence around the impact of strengthening the HIV treatment cascade in TB patients and explore recent findings about how best to deliver integrated TB/HIV services. RECENT F...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Lessells RJ,Swaminathan S,Godfrey-Faussett P

    更新日期:2015-11-01 00:00:00

  • Psychosocial, mental health, and behavioral issues of aging with HIV.

    abstract:PURPOSE OF REVIEW:People with HIV continue to live with the health consequences of an episodic illness that limits their ability to fully participate in society, particularly for the growing number of older people living with HIV. The present review describes the recent evidence exploring the psychosocial challenges fa...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Rueda S,Law S,Rourke SB

    更新日期:2014-07-01 00:00:00

  • Can the United States achieve 90-90-90?

    abstract:PURPOSE OF REVIEW:To summarize recent trends in knowledge of HIV status, care and viral suppression, and the status of implementation of relevant contextual requirements for the United States to achieve the 90-90-90 goals. Recently, the US government announced a plan to decrease HIV incidence by over 90% by 2030. Reach...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Hall HI,Brooks JT,Mermin J

    更新日期:2019-11-01 00:00:00

  • Evolving clinical phenotypes in HIV-associated neurocognitive disorders.

    abstract:PURPOSE OF REVIEW:To describe the changes in the presentation of HIV-associated neurocognitive disorders (HAND) comparing the current combination antiretroviral therapy (cART) treatment era to the pre-cART era. RECENT FINDINGS:The frequency of the most severe stage of HAND, HIV-associated dementia (HAD), has decreased...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Sacktor N,Robertson K

    更新日期:2014-11-01 00:00:00

  • Biology of HIV mucosal transmission.

    abstract:PURPOSE OF REVIEW:HIV-1 mucosal transmission plays a critical role in HIV-1 infection and AIDS pathogenesis. This review summarizes the latest advances in biological studies of HIV-1 mucosal transmission, highlighting the implications of these studies in the development of microbicides to prevent HIV-1 transmission. R...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章


    authors: Wu L

    更新日期:2008-09-01 00:00:00

  • Emerging HIV-1 drug resistance after roll-out of antiretroviral therapy in sub-Saharan Africa.

    abstract:PURPOSE OF REVIEW:This review provides an update of recent data on the development of HIV-1 drug resistance during treatment and its transmission in sub-Saharan Africa after the scale-up of antiretroviral therapy (ART). RECENT FINDINGS:Evidence is accumulating of a rising prevalence of transmitted HIV drug resistance ...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Hamers RL,Sigaloff KC,Kityo C,Mugyenyi P,de Wit TF

    更新日期:2013-01-01 00:00:00

  • HIV and ageing: improving quantity and quality of life.

    abstract:PURPOSE OF REVIEW:Evidence-based strategies are needed to address the growing complexity of care of those ageing with HIV so that as life expectancy is extended, quality of life is also enhanced. RECENT FINDINGS:Modifiable contributing factors to the quantity and quality of life in adults ageing with HIV include: burd...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Althoff KN,Smit M,Reiss P,Justice AC

    更新日期:2016-09-01 00:00:00

  • Mortal allies: human immunodeficiency virus and noncommunicable diseases.

    abstract:PURPOSE OF REVIEW:HIV-infected individuals have improved access to antiretroviral therapy. This has resulted in a shift in causes of mortality from infectious diseases to noncommunicable diseases including cardiovascular disease, chronic kidney disease (CKD) and malignancies. This review will look at the epidemiologica...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Mayne ES,George JA

    更新日期:2017-03-01 00:00:00

  • HIV, alcohol, and noninjection drug use.

    abstract:PURPOSE OF REVIEW:Alcohol and noninjection drug use has been shown to be associated with increased risk of HIV infection in select populations. In this review, we discuss recent data on the prevalence of alcohol and noninjection drug use and the relationship to HIV acquisition and transmission risk. RECENT FINDINGS:A ...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Van Tieu H,Koblin BA

    更新日期:2009-07-01 00:00:00

  • The mucosal barrier and immune activation in HIV pathogenesis.

    abstract:PURPOSE OF REVIEW:Significant gastrointestinal pathology occurs in progressive HIV and simian immunodeficiency virus (SIV) infections. This review will examine the relationship between the detrimental events to the gastrointestinal tract during the acute phase of infection and disease progression through the chronic ph...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章


    authors: Brenchley JM,Douek DC

    更新日期:2008-05-01 00:00:00

  • Direct-acting antiviral-based therapy for acute hepatitis C coinfection.

    abstract:PURPOSE OF REVIEW:Modern interferon (IFN)-free, and potentially also ribavirin-free, combinations consisting of two or three direct-acting antivirals (DAAs) are highly efficacious in treating chronic hepatitis C virus (HCV) infection with treatment durations being much shorter and with much more favorable toxicity prof...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Boesecke C,Page E

    更新日期:2015-09-01 00:00:00

  • Transforming lives and empowering communities: evidence, harm reduction and a holistic approach to people who use drugs.

    abstract:PURPOSE OF REVIEW:We reviewed the global state of harm reduction for people who use and/or inject drugs. KEY FINDINGS:Although harm reduction is now the key response to HIV among people who use drugs globally, intervention coverage remains suboptimal, exacerbated by chronic under-funding, declining donor support and l...

    journal_title:Current opinion in HIV and AIDS

    pub_type: 杂志文章,评审


    authors: Southwell M,Shelly S,MacDonald V,Verster A,Maher L

    更新日期:2019-09-01 00:00:00