More than osteoporosis: age-specific issues in bone health.

Abstract:

PURPOSE OF REVIEW:The interaction between fall and fracture risk factors is an area of increasing clinical relevance, but little information is known about the age-specific issues in bone health unique to HIV-infected adults. The present review will focus on what is known about falls and fall risk factors among HIV-infected adults, and then review the association between decreased muscle, increased adiposity, and frailty with both low bone mineral density (BMD) and falls. RECENT FINDINGS:The rate of falls among middle-aged HIV-infected adults is similar to that of HIV-uninfected adults 65 years and older. Many of the clinical factors that contribute to low BMD overlap with risk factors for falls, resulting in a high risk of a serious fall among older adults with the greatest risk for a fracture. Low muscle mass, increased adiposity and metabolic syndrome, physical function impairment and frailty, common among older HIV-infected adults, contribute to an increased risk for low BMD and falls, and subsequently, may increase the risk of fracture among HIV-infected older adults. SUMMARY:Interventions with dual benefit on reducing fall risk and improving BMD are likely to have the greatest impact on fracture prevention in the older, HIV-infected adult.

journal_name

Curr Opin HIV AIDS

authors

Erlandson KM,Guaraldi G,Falutz J

doi

10.1097/COH.0000000000000258

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

343-50

issue

3

eissn

1746-630X

issn

1746-6318

journal_volume

11

pub_type

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