Abstract:
:The mechanical properties of soft biological tissues in general and early stage engineered tissues in particular limit the feasibility of conventional tensile tests for their mechanical characterisation. Furthermore, the most important mode in development of deep tissue injury (DTI) is compression. Therefore, an inverse numerical-experimental approach using a finite spherical indentation test is proposed. To demonstrate the feasibility of the approach indentation tests are applied to bio-artificial muscle (BAM) tissue. BAMs are cultured in vitro with (n = 20) or without (n = 12) myoblast cells to quantify the effect of the cells on the passive transverse mechanical properties. Indentation tests are applied up to 80% of the tissue thickness. A non-linear Neo-Hookean constitutive model is fitted to the experimental results for parameter estimation. BAMs with cells demonstrated both stiffer and more non-linear material behaviour than BAMs without cells.
journal_name
Comput Methods Biomech Biomed Enginauthors
Cox MA,Gawlitta D,Driessen NJ,Oomens CW,Baaijens FPdoi
10.1080/10255840701771768subject
Has Abstractpub_date
2008-10-01 00:00:00pages
585-92issue
5eissn
1025-5842issn
1476-8259journal_volume
11pub_type
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