Neutrophils, but not lymphocytes or monocytes, infiltrate maternal systemic vasculature in women with preeclampsia.

Abstract:

OBJECTIVE:Leukocytes are activated in women with preeclampsia, but the class of leukocytes that infiltrates the maternal vasculature and, therefore, is most likely to cause vascular dysfunction is not known. METHODS:Subcutaneous fat biopsies were obtained at Cesarean section or abdominal surgery from 7 normal non-pregnant women, 7 women with normal pregnancies, and 7 women with preeclampsia. Tissues were immunohistochemically stained for CD14, a monocyte/macrophage antigen, CD99, a lymphocyte antigen, and CD66b, a neutrophil antigen. RESULTS:CD14 stained cells were found infiltrated into fat tissue but were not present in vessels for any of the groups. CD99-stained cells were present in approximately 20% to 30% of vessels with no difference among groups. CD66b-stained cells were present in all groups with a significantly greater percentage of vessels stained for preeclamptic than normal pregnant or normal non-pregnant women (70 +/- 6 vs. 43 +/- 9 vs. 21 +/- 5%, respectively, p < 0.01). CD66b cells were the most abundant cell type that infiltrated vessels of preeclamptic women. CONCLUSIONS:1) A significantly greater number of neutrophils adhered to endothelium and infiltrated into the intimal space in the maternal systemic vasculature of preeclamptic women than in that of normal pregnant women or normal non-pregnant women; 2) No significant difference in lymphocyte infiltration was observed among the patient groups, and lymphocytes were present in much lower numbers than-neutrophils; 3) Monocytes/macrophages were found in fat tissue but not in vessels. We speculate that neutrophils are the class of leukocytes that cause the majority of vascular cell dysfunction in women with preeclampsia.

journal_name

Hypertens Pregnancy

authors

Cadden KA,Walsh SW

doi

10.1080/10641950801958067

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

396-405

issue

4

eissn

1064-1955

issn

1525-6065

pii

905424225

journal_volume

27

pub_type

杂志文章
  • Predicting transformation from gestational hypertension to preeclampsia in clinical practice: a possible role for 24 hour ambulatory blood pressure monitoring.

    abstract:OBJECTIVE:To identify parameters that may assist clinicians in predicting which women will develop preeclampsia (PE) after initially presenting with gestational hypertension (GH). METHODS:118 women were recruited to the study with GH or PE. They were divided into three groups based on their diagnosis at delivery- (1) ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950601147952

    authors: Davis GK,Mackenzie C,Brown MA,Homer CS,Holt J,McHugh L,Mangos G

    更新日期:2007-01-01 00:00:00

  • Hypertensive disorders in primigravid black South African women: A one-year descriptive analysis.

    abstract:OBJECTIVE:To describe the incidence and obstetric and perinatal outcomes in primigravid Black South Africans with hypertensive disorders of pregnancy (HDP). METHOD:All primigravidae who booked for antenatal care were followed up until hospital discharge. Relevant clinical and demographic data were collected in structu...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1193190

    authors: Moodley J,Onyangunga OA,Maharaj NR

    更新日期:2016-11-01 00:00:00

  • Elevated serum-soluble Fas in preeclampsia: correlation with clinical, laboratory, and Doppler parameters.

    abstract:OBJECTIVES:(i) To compare the levels of soluble Fas (sFas) in the sera of patients with variable degrees of preeclampsia and in healthy gravidas; and (ii) to correlate sFas with clinical, laboratory, and Doppler parameters in preeclampsia. METHODS:Fifty patients with mild preeclampsia, 50 patients with severe preeclam...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2010.544804

    authors: El-Sherbiny W,Soliman A,El-Mazny A

    更新日期:2011-01-01 00:00:00

  • Markers for presymptomatic prediction of preeclampsia and intrauterine growth restriction.

    abstract::Preeclampsia and intrauterine growth restriction are both characterized by placental malfunction. The pathological processes of abnormal trophoblast invasion, partial absence of maternal spiral artery modification, increased apoptosis of trophoblast cells, and placental ischemia are all associated with the release of ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.1081/PRG-120028292

    authors: Tjoa ML,Oudejans CB,van Vugt JM,Blankenstein MA,van Wijk IJ

    更新日期:2004-01-01 00:00:00

  • Basic fibroblast growth factor and hypertensive disorders in pregnancy.

    abstract:OBJECTIVE:We examined serum concentrations of basic fibroblast growth factor (bFGF) in women with hypertensive disorders in pregnancy and analyzed whether serum concentrations of bFGF can be used as a discriminator between mild and severe preeclampsia. METHODS:One hundred and twenty pregnant women were included in thi...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120016790

    authors: Hohlagschwandtner M,Knöfler M,Ploner M,Zeisler H,Joura EA,Husslein P

    更新日期:2002-01-01 00:00:00

  • ADAMTS 1, 4, 12, and 13 levels in maternal blood, cord blood, and placenta in preeclampsia.

    abstract::The aim of this study is to compare ADAMTS (A Disintegrin and Metalloprotease Domains with Thrombospondins motifs) 1, 4, 12, and 13 levels in maternal and cord blood and placental tissue between preeclampsia and uncomplicated pregnancies. The enzyme-linked immunosorbent assay (ELISA) results showed that ADAMTS 1, 4, 1...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1397690

    authors: Namlı Kalem M,Kalem Z,Yüce T,Soylemez F

    更新日期:2018-02-01 00:00:00

  • Serum apelin and galectin-3 in preeclampsia in Iraq.

    abstract:OBJECTIVE:This study investigates the correlation between serum apelin and galectin-3 levels with insulin resistance (IR) in women with preeclampsia (PE). METHODS:Serum apelin, galectin-3, and insulin levels were measured in 60 PE women and 30 normotensive pregnant. RESULTS:The PE group had significantly lower apelin...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1777300

    authors: Sattar Taha A,Zahraei Z,Al-Hakeim HK

    更新日期:2020-11-01 00:00:00

  • Is gestational hypertension associated with affective temperaments?

    abstract::Objective: Gestational hypertension (GH) is an important pregnancy complication. Sparse studies have shown a correlation between this complication and psychological disorders in patients. In this study, we aimed to assess the possible association between affective temperaments and GH.Methods: This cross-sectional stud...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1749279

    authors: Rezaei Ardani A,Tara F,Naghizadeh Kashani S,Hatami SB,Emadzadeh M,Nahidi M

    更新日期:2020-05-01 00:00:00

  • Pathological uterine perfusion in the second trimester is not associated with neutrophil activation.

    abstract:OBJECTIVE:Preeclampsia and intrauterine growth retardation (IUGR) are associated with elevated concentrations of myeloperoxidase (MPO) and polymorphonuclear (PMN) elastase, which indicate maternal neutrophil activation. The aim of the study was to measure maternal MPO and PMN elastase plasma concentrations in second tr...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-120024027

    authors: Stepan H,Heihoff-Klose A,Faber R

    更新日期:2003-01-01 00:00:00

  • Counselling and management of cardiovascular risk factors after preeclampsia.

    abstract:OBJECTIVE:Women with a history of preeclampsia have an increased risk of cardiovascular disease. Gynaecologists have an important role in the counselling and management of cardiovascular risk factors after preeclampsia. We aimed to assess the role of gynaecologists in informing women on interventions and risk factor fo...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1100311

    authors: van Kesteren F,Visser S,Hermes W,Teunissen PW,Franx A,van Pampus MG,Mol BW,de Groot CJ

    更新日期:2016-01-01 00:00:00

  • Clinical usefulness of maternal body mass index in twin pregnancies.

    abstract:OBJECTIVE:We examined whether maternal body mass index (BMI) during prepregnancy is useful for prediction of maternal preeclampsia in twin pregnancies. METHODS:We studied 250 dichorionic twin pregnancies and 3196 singleton pregnancies. Maternal BMI was calculated during prepregnancy in both twin and singleton pregnanc...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/prg-100101988

    authors: Suzuki S,Yoneyama Y,Sawa R,Shin S,Araki T

    更新日期:2000-01-01 00:00:00

  • Hypertensive disorders during monozygotic and dizygotic twin gestations: A population-based study.

    abstract:OBJECTIVE:To determine whether the incidence of hypertensive disorders is different in monozygotic compared to dizygotic twin pregnancies. METHODS:A registry-based survey of twin pregnancies delivered during 2003 to 2012. We used the best clinical estimate of zygosity based on the concept that all monochorionic twins ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1197936

    authors: Lučovnik M,Blickstein I,Lasič M,Fabjan-Vodušek V,Bržan-Simenc G,Verdenik I,Tul N

    更新日期:2016-11-01 00:00:00

  • Cytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women.

    abstract:OBJECTIVE:To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS:Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lympho...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950701885006

    authors: van Nieuwenhoven AL,Moes H,Heineman MJ,Santema J,Faas MM

    更新日期:2008-01-01 00:00:00

  • The effect of mode of delivery on placental chorionic plate vascular reactivity.

    abstract:OBJECTIVE:To determine whether delivery mode influences placental chorionic plate arterial and venous vascular reactivity. METHODS:Normal term placentas were obtained after vaginal delivery or cesarean section. Chorionic plate arterial and venous function was assessed by wire myography. RESULTS:Sodium nitroprusside-i...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10601330701274824

    authors: Mills TA,Baker PN,Wareing M

    更新日期:2007-01-01 00:00:00

  • Ethnic differences in the monthly variation of preeclampsia among Bedouin and Jewish parturients in the Negev.

    abstract:OBJECTIVE:To assess seasonal patterns and monthly variations in the incidence of preeclampsia in the Jewish and Bedouin population in Israel, assuming that ethnicity and environmental factors may have a role in the causal mechanism. METHODS:A retrospective population-based study comparing all singleton pregnancies of ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641950902968692

    authors: Shental O,Friger M,Sheiner E

    更新日期:2010-01-01 00:00:00

  • Perinatal and maternal outcome following abruptio placentae.

    abstract:OBJECTIVE:To characterize the maternal and fetal presentation of abruptio placentae and associated maternal and fetal morbidity and mortality by mode of delivery and fetal status on admission. STUDY DESIGN:Perinatal data (gestational age > 24 weeks) from women with abruptio placentae at a tertiary referral center were...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-100106969

    authors: Witlin AG,Sibai BM

    更新日期:2001-01-01 00:00:00

  • SDF-1/CXCL12 and CXCR4 gene variants, and elevated serum SDF-1 levels are associated with preeclampsia.

    abstract:OBJECTIVE:We aimed to compare the frequencies of stromal cell-derived factor-1 (SDF-1) 3'A and CXCR4 single-nucleotide polymorphisms (SNPs) and serum SDF-1 levels in patients with preeclampsia (PE). METHODS:In total, 89 women with PE and 89 control women were included in the study. Genotyping was done by polymerase ch...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2016.1250904

    authors: Karakus S,Bagci B,Bagci G,Sancakdar E,Yildiz C,Akkar O,Cetin A

    更新日期:2017-05-01 00:00:00

  • A randomised, double-blinded, placebo-controlled study of the phosphodiesterase type 5 inhibitor sildenafil for the treatment of preeclampsia.

    abstract:OBJECTIVE:To determine if the phosphodiesterase type 5 inhibitor sildenafil prolongs pregnancy in women with preeclampsia. METHODS:Women with preeclampsia at gestational ages 24-34 weeks were recruited from nine hospitals in the UK, and randomly assigned to sildenafil citrate or placebo. Medication was increased every...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/10641950802601278

    authors: Samangaya RA,Mires G,Shennan A,Skillern L,Howe D,McLeod A,Baker PN

    更新日期:2009-08-01 00:00:00

  • CA-125 and CRP are elevated in preeclampsia.

    abstract:OBJECTIVE:To determine the relationship between the cancer antigen-125 (CA-125) and C-reactive protein (CRP) with preeclampsia and eclampsia. METHODS:The study group included 54 preeclamptic/eclamptic women, and 56 healthy pregnant women served as the control group. Mean arterial pressure (MAP) and albumin levels were...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950802601187

    authors: Cebesoy FB,Balat O,Dikensoy E,Kalayci H,Ibar Y

    更新日期:2009-05-01 00:00:00

  • Serum levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and soluble vascular endothelial growth factor receptor (sVEGFR)-1 and -2 in HIV associated preeclampsia.

    abstract:OBJECTIVE:The angiogenic-antiangiogenic imbalance evident in preeclampsia (PE) may be used as a predictive tool to identify women likely to develop the clinical features in early pregnancy. METHOD:This retrospective study examined normotensive pregnant (n = 38) and preeclamptic (n = 38) HIV-infected and uninfected wom...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2017.1280049

    authors: Thakoordeen S,Moodley J,Naicker T

    更新日期:2017-05-01 00:00:00

  • Intraplatelet cyclic guanosine-3',5'-monophosphate levels during pregnancy and preeclampsia.

    abstract:OBJECTIVE:To investigate the intraplatelet cyclic guanosine-3',5'-monophosphate (cGMP) levels during normal pregnancy and preeclampsia. STUDY DESIGN:Pregnant women (n = 15), women with preeclampsia (n = 15), and nonpregnant, normotensive women (n = 15) were included. Intraplatelet cyclic guanosine-3',5'-monophosphate ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/PRG-200030860

    authors: Teran E,Escudero C,Vivero S,Enriquez A,Calle A

    更新日期:2004-01-01 00:00:00

  • Management of severe pregnancy-induced hypertension after 34 weeks of gestation: A prospective study to reduce the rate of cesarean section.

    abstract:OBJECTIVE:The aim of this study was to reduce the rate of cesarean section (CS) in severe pregnancy-induced hypertension (PIH) by introducing a set of indicative criteria for CS. METHODS:Labor induction was attempted in Japanese patients (n = 41) with severe PIH after 34 weeks of gestation. Vital signs and symptoms th...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2015.1115061

    authors: Shibata T,Nakago S,Kato H,Tokuda H,Matsuki R,Kotsuji F

    更新日期:2016-01-01 00:00:00

  • Nutritional status of women with gestational hypertension compared with normal pregnant women.

    abstract:BACKGROUND:Some evidence indicated the role of nutrition in the development of hypertensive disorders of pregnancy. METHODS:This case-control study was conducted on 113 women with gestational hypertension and 150 healthy pregnant women referred to Shahid Akbarabadi Hospital in Tehran. A demographic questionnaire was f...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2013.784782

    authors: Kazemian E,Dorosty-Motlagh AR,Sotoudeh G,Eshraghian MR,Ansary S,Omidian M

    更新日期:2013-05-01 00:00:00

  • Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats.

    abstract::The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery dur...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2020.1762894

    authors: Rozkova I,Brusentsev E,Igonina T,Ragaeva D,Petrova O,Tikhonova MA,Akopyan AA,Amstislavskaya TG,Antonov YV,Amstislavsky S

    更新日期:2020-08-01 00:00:00

  • MicroRNA analysis in placentas from patients with preeclampsia: comparison of new and published results.

    abstract:OBJECTIVE:The aim was to identify differences in microRNA expression between patients with and without preeclampsia. METHODS:Microarray-based study was carried out with placental samples. RESULTS:Comparison of eight previous studies with the current study revealed a total of 138 microRNAs; only 20/138 (14%), however,...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章,评审

    doi:10.3109/10641955.2013.807819

    authors: Betoni JS,Derr K,Pahl MC,Rogers L,Muller CL,Packard RE,Carey DJ,Kuivaniemi H,Tromp G

    更新日期:2013-11-01 00:00:00

  • The activity of erythrocyte sodium-proton exchanger in women with pregnancy- induced hypertension.

    abstract:BACKGROUND:Hypertension that develops after 20 gestational weeks and is defined as pregnancy-induced hypertension (PIH). The main cause of PIH is vasoconstriction and the thickening of vascular media, which decreases vascular capacity and increases peripheral resistance. One of the theories postulated to explain this p...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641950600601835

    authors: Kwiatkowski S,Kwiatkowska E,Czajka R,Ciechanowski K,Kedzierska K,Bober J,Rzepka R,Golembiewska E,Chlubek D

    更新日期:2006-01-01 00:00:00

  • Effects of in vitro culture at the preimplantation embryo stage on early development and hypertension in ISIAH rats.

    abstract::Objective: The study investigates how IVC and ET affect hypertensive phenotype in ISIAH rats. Methods: ISIAH rats born as the result of ET and IVC were compared with naturally conceived controls. Results: Embryo transfer from hypertensive ISIAH rats to normotensive recipient dams caused lower SBP and DBP in the female...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1080/10641955.2019.1647232

    authors: Igonina TN,Ragaeva DS,Petrova OM,Rozkova IN,Brusentsev EY,Amstislavsky SY

    更新日期:2019-11-01 00:00:00

  • Mortality and morbidity associated with early-onset preeclampsia.

    abstract:OBJECTIVE:To examine the management of early-onset preeclampsia and its maternal and fetal morbidity and mortality. DESIGN:Retrospective cohort study of 49,812 births at a university teaching hospital between June 1986 and March 1997. Seventy-one women were identified with a diagnosis of preeclampsia with an onset at ...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.1081/prg-100100138

    authors: Murphy DJ,Stirrat GM

    更新日期:2000-01-01 00:00:00

  • Massive respiratory dysfunction as sign of fulminant peripartum cardiomyopathy (PPCM).

    abstract:OBJECTIVE:Case report of a 35-year-old gravida 3, para 2, at 40 + 6 weeks with massive respiratory dysfunction with need of oxygenation, requiring cesarean section. CASE REPORT:Postpartum investigations revealed pathological cardiomegaly with left ventricular failure (NYHAIV). Cardiac biopsy diagnosed postpartum dilat...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641955.2012.679014

    authors: Freerksen N,Jaekel J,Menon AK,Maass N,Bauerschlag D

    更新日期:2012-01-01 00:00:00

  • Mechanisms of endothelium-dependent relaxation in myometrial resistance vessels and their alteration in preeclampsia.

    abstract:OBJECTIVE:To investigate the importance of prostacyclin and nitric oxide synthesis in endothelium-dependent relaxation in myometrial resistance vessels, and to test the hypothesis that a deficiency in nitric oxide synthesis contributes to the known alterations in endothelial function in preeclampsia. METHODS:Thirty-si...

    journal_title:Hypertension in pregnancy

    pub_type: 杂志文章

    doi:10.3109/10641959909009611

    authors: Ashworth JR,Baker PN,Warren AY,Johnson IR

    更新日期:1999-01-01 00:00:00