Sham surgical embryo transfer affects offspring neurodevelopment and manifestation of hypertensive phenotype in ISIAH rats.

Abstract:

:The study investigates how surgery during pregnancy, i.e., sham operation associated with embryo transfer, affects hypertensive phenotype in ISIAH rats genetically predisposed to hypertension. ISIAH rats born after maternal surgery at fourth day of pregnancy were compared with naturally conceived controls. Surgery during pregnancy in ISIAH rats caused acceleration of neurodevelopment in young offspring, as well as aggravating hypertension, suppressing exploratory activity, reducing hippocampal BDNF expression, and compensatory increasing of hippocampal neuronal density in adult ISIAH offspring. Maternal surgery during early pregnancy caused alterations in offspring phenotype in hypertensive ISIAH rat model.

journal_name

Hypertens Pregnancy

authors

Rozkova I,Brusentsev E,Igonina T,Ragaeva D,Petrova O,Tikhonova MA,Akopyan AA,Amstislavskaya TG,Antonov YV,Amstislavsky S

doi

10.1080/10641955.2020.1762894

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

283-294

issue

3

eissn

1064-1955

issn

1525-6065

journal_volume

39

pub_type

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