Kinetic analysis of double-strand break rejoining reveals the DNA reparability of gamma-irradiated tobacco cultured cells.

abstract：:The purpose of this multi-institutional Phase II trial study was to prospectively investigate the efficacy of the herbal medicine TJ-14 for acute radiation-induced enteritis (ARE). TJ-14 was administered orally as a first-line treatment for ARE. The primary end point was efficacy at 1 week. The secondary end points we...

journal_title：Journal of radiation research

authors： Murai T,Matsuo M,Tanaka H,Manabe Y,Takaoka T,Hachiya K,Yamaguchi T,Otsuka S,Shibamoto Y

更新日期：2020-01-23 00:00:00

abstract：:This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for ge...

journal_title：Journal of radiation research

authors： Minicucci EM,Kowalski LP,Maia MA,Pereira A,Ribeiro LR,de Camargo JL,Salvadori DM

更新日期：2005-06-01 00:00:00

abstract：:We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2...

journal_title：Journal of radiation research

authors： Kataoka T,Sakoda A,Ishimori Y,Toyota T,Nishiyama Y,Tanaka H,Mitsunobu F,Yamaoka K

更新日期：2011-01-01 00:00:00

abstract：:We investigated the sensitizing effect of the 2-nitroimidazole analogue doranidazole, a new hypoxic radiosensitizer, on radiation-induced apoptosis in L5178Y cells. Apoptosis was assessed by checking DNA ladder formation, the presence of sub-G1 peaks in flow cytometry, and chromatin condensation. A radiosensitizing ef...

journal_title：Journal of radiation research

authors： Aoki M,Furusawa Y,Shibamoto Y,Kobayashi A,Tsujitani M

更新日期：2002-06-01 00:00:00

abstract：:Neutron dose is transferred to biological materials through the recoil protons produced by elastic scattering. When a low-velocity proton collides with the atoms or molecules of a target, it changes to a hydrogen atom by electron capture; this hydrogen atom then changes to a proton by losing the electron. Because the ...

journal_title：Journal of radiation research

authors： Endo S

更新日期：2004-09-01 00:00:00

abstract：:New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesor...

journal_title：Journal of radiation research

authors： Alickikus ZA,Kuru A,Aydin B,Akcay D,Gorken IB

更新日期：2020-03-23 00:00:00

abstract：:Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and...

journal_title：Journal of radiation research

authors： Kashihara T,Murakami N,Tselis N,Kobayashi K,Tsuchida K,Shima S,Masui K,Yoshida K,Takahashi K,Inaba K,Umezawa R,Igaki H,Ito Y,Kato T,Uno T,Itami J

更新日期：2019-07-01 00:00:00

abstract：:In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...

journal_title：Journal of radiation research

authors： Yatagai F,Sugasawa K,Enomoto S,Honma M

更新日期：2009-09-01 00:00:00

abstract：:To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...

journal_title：Journal of radiation research

authors： Okaichi K,Usui A,Ohnishi T,Okumura Y

更新日期：2002-12-01 00:00:00

abstract：:We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...

journal_title：Journal of radiation research

authors： Ryo H,Nakajima H,Nomura T

更新日期：2006-01-01 00:00:00

abstract：:The radioprotective activity of the hydroalcoholic extract of jamun seeds (SCE) was studied in mice exposed to different doses of gamma radiation. The mice were injected with 0, 5, 10, 20, 40, 60, 80, 100, 120, 140 or 160 mg/kg body weight of SCE, before exposure to 10 Gy of gamma radiation, to select the optimum dose...

journal_title：Journal of radiation research

authors： Jagetia GC,Baliga MS,Venkatesh P

更新日期：2005-03-01 00:00:00

abstract：:The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...

journal_title：Journal of radiation research

authors： Ochiai S,Nomoto Y,Watanabe Y,Yamashita Y,Toyomasu Y,Kawamura T,Takada A,Noriko,Sakuma H

更新日期：2016-09-01 00:00:00

abstract：:The aim of the present study was to examine the excess relative risk for leukemia mortality and all cancers, except leukemia, among Hiroshima atomic-bomb survivors by applying ABS93D and ABS2000D. Particular attention was given to any difference in the neutron-dose estimates between the two dosimetry systems. The stud...

journal_title：Journal of radiation research

authors： Katayama H,Matsuura M,Endo S,Hoshi M,Ohtaki M,Hayakawa N

更新日期：2002-03-01 00:00:00

abstract：:We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...

journal_title：Journal of radiation research

authors： Hojo H,Zenda S,Akimoto T,Kohno R,Kawashima M,Arahira S,Nishio T,Tahara M,Hayashi R,Sasai K

更新日期：2012-09-01 00:00:00

abstract：:Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...

journal_title：Journal of radiation research

authors： Izumi Y,Fujii K,Yamamoto S,Matsuo K,Namatame H,Taniguchi M,Yokoya A

更新日期：2017-01-01 00:00:00

abstract：:The brachytherapy dose calculations used in treatment planning systems (TPSs) have conventionally been performed assuming homogeneous water. Using measurements and a Monte Carlo simulation, we evaluated the dosimetric impact of an air passage on brachytherapy for bronchus cancer. To obtain the geometrical characterist...

journal_title：Journal of radiation research

authors： Okamoto H,Wakita A,Nakamura S,Nishioka S,Aikawa A,Kato T,Abe Y,Kobayashi K,Inaba K,Murakami N,Itami J

更新日期：2016-11-01 00:00:00

abstract：:This study aimed to clarify the motivations and timing of the decision to become radiation oncologists. MATERIALS AND METHODS:We conducted an online survey for new members of the Japanese Society for Radiation Oncology (JASTRO). RESULTS:The response rate was 43.3%. Data of the 79 respondents who wanted to obtain a b...

journal_title：Journal of radiation research

authors： Murakami Y,Noda SE,Hatayama Y,Maebayashi T,Jingu K,Nagata Y,Mizowaki T

更新日期：2020-09-08 00:00:00

abstract：:The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...

journal_title：Journal of radiation research

authors： Sakurai T,Kiyokawa T,Narita E,Suzuki Y,Taki M,Miyakoshi J

更新日期：2011-01-01 00:00:00

abstract：:To understand the biological response of normal cells to fractionated carbon beam irradiation, the effects of potentially lethal damage repair (PLDR) and sublethal damage repair (SLDR) were both taken into account in a linear-quadratic (LQ) model. The model was verified by the results of a fractionated cell survival e...

journal_title：Journal of radiation research

authors： Wada M,Suzuki M,Liu C,Kaneko Y,Fukuda S,Ando K,Matsufuji N

更新日期：2013-09-01 00:00:00

abstract：:Recently fluorescence in situ hybridization protocols have been developed which allow the painting of individual chromosomes using DNA-libraries from sorted human chromosomes. This approach has the particular advantage that radiation induced chromosome translocations can be easily detected, if chromosomes of distinctl...

journal_title：Journal of radiation research

authors： Popp S,Cremer T

更新日期：1992-03-01 00:00:00

abstract：:Non-homologous end-joining (NHEJ) is the predominant pathway for the repair of DNA double-strand breaks (DSBs) in human cells. XRCC4 is indispensable to NHEJ and functions together with DNA ligase IV in the rejoining of broken DNA ends. Artemis is a nuclease required for trimming of some, but not all, types of broken ...

journal_title：Journal of radiation research

authors： Katsube T,Mori M,Tsuji H,Shiomi T,Shiomi N,Onoda M

更新日期：2011-01-01 00:00:00

abstract：:The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...

journal_title：Journal of radiation research

authors： Amelio D,Winter M,Habermehl D,Jäkel O,Debus J,Combs SE

更新日期：2013-07-01 00:00:00

abstract：:The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...

journal_title：Journal of radiation research

authors： Yang S,Yang S,Liao W,Huang R,Li B,Lu S,Li C,Wang Z,Li C,Pei J,Wen H,Zhang S

更新日期：2019-10-23 00:00:00

abstract：:In vivo laboratory experiments on tritium gas (HT) fixation in pine trees were conducted using one-way circuit inhalation apparatus and dwarf pine trees. After 2 hours of exposure to HT, tritium distribution in pine needles, branches, trunk, roots and soil was measured. The specific activity of tritium in pine needles...

journal_title：Journal of radiation research

authors： Ichimasa M,Ichimasa Y,Akita Y

更新日期：1989-12-01 00:00:00

abstract：:X-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the ef...

journal_title：Journal of radiation research

authors： Sakiyama H,Yasukawa M,Nishijima M,Wada E,Kanegasaki S

更新日期：1993-12-01 00:00:00

abstract：:To clarify the nature of the genes that contribute to the radiosensitivity of human hematopoietic stem/progenitor cells (HSPCs), we analyzed the gene expression profiles detected in HSPCs irradiated with 2 Gy X-rays after culture with or without an optimal combination of hematopoietic cytokines. Highly purified CD34(+...

journal_title：Journal of radiation research

authors： Tsujiguchi T,Hirouchi T,Monzen S,Tabuchi Y,Takasaki I,Kondo T,Kashiwakura I

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...

journal_title：Journal of radiation research

authors： Demirel C,Kilçiksiz S,Ay OI,Gürgül S,Ay ME,Erdal N

更新日期：2009-01-01 00:00:00

abstract：:Low-doses of irradiation have been reported to have beneficial effects, particularly anti-tumor effects. In this paper, we show the effects of the low-dose irradiation on T cell activation induced by dendritic cells (DCs). DCs, which had been pre-irradiated at 0.02-1.0 Gy from a (137)Cs source, were cultured with allo...

journal_title：Journal of radiation research

authors： Shigematsu A,Adachi Y,Koike-Kiriyama N,Suzuki Y,Iwasaki M,Koike Y,Nakano K,Mukaide H,Imamura M,Ikehara S

更新日期：2007-01-01 00:00:00

abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

journal_title：Journal of radiation research

authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

更新日期：2014-07-01 00:00:00

abstract：:The aim of this study was to evaluate the effectiveness and tolerability of definitive chemo-radiation or radiotherapy alone in patients with esophageal cancer. We retrospectively analyzed the medical records of n = 238 patients with squamous cell carcinoma or adenocarcinoma of the esophagus treated with definitive ra...

journal_title：Journal of radiation research

authors： Haefner MF,Lang K,Krug D,Koerber SA,Uhlmann L,Kieser M,Debus J,Sterzing F

更新日期：2015-07-01 00:00:00