Abstract:
:We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2000 day•Bq/m(3), activation of SOD activities in plasma, liver, pancreas, heart, thymus, and kidney showed dose-rate effects. Our results also suggested that continuous exposure to radon increased SOD activity, but SOD activity transiently returned to normal levels at around 2 days. Moreover, we classified the organs into four groups (1. plasma, brain, lung; 2. heart, liver, pancreas, small intestine; 3. kidney, thymus; 4. stomach) based on changes in SOD activity. Thymus had the highest responsiveness and stomach had lowest. These data provide useful baseline measurements for future studies on radon effects.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Kataoka T,Sakoda A,Ishimori Y,Toyota T,Nishiyama Y,Tanaka H,Mitsunobu F,Yamaoka Kdoi
10.1269/jrr.10072subject
Has Abstractpub_date
2011-01-01 00:00:00pages
775-81issue
6eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/10072journal_volume
52pub_type
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