Abstract：
:Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyzed in migration and adhesion experiments with and without photon and carbon ion irradiation. Expression of integrins was determined by quantitative FACS analysis. Matrix metalloproteinase concentrations within cell culture supernatants were investigated by enzyme-linked immunosorbent assay (ELISA). Statistical analysis was performed using Student's t-test. Both photon and carbon ion irradiation significantly reduced chemotactic medulloblastoma cell transmigration through 8-μm pore size membranes, while simultaneously increasing adherence to fibronectin- and collagen I- and IV-coated surfaces. Correspondingly, both photon and carbon ion irradiation downregulate soluble MMP9 concentrations, while upregulating cell surface expression of proadhesive extracellular matrix protein-binding integrin α5. The observed phenotype of radiation-altered motility is more pronounced following carbon ion than photon irradiation. Both photon and (even more so) carbon ion irradiation are effective in inhibiting medulloblastoma cell migration through downregulation of matrix metalloproteinase 9 and upregulation of proadhesive cell surface integrin α5, which lead to increased cell adherence to extracellular matrix proteins.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Rieken S,Rieber J,Brons S,Habermehl D,Rief H,Orschiedt L,Lindel K,Weber KJ,Debus J,Combs SEdoi
10.1093/jrr/rru120subject
Has Abstractpub_date
2015-05-01 00:00:00pages
430-6issue
3eissn
0449-3060issn
1349-9157pii
rru120journal_volume
56pub_type
杂志文章abstract：:Several models for the action of mixed irradiation with two types of radiation have been proposed in the last two decades, although the superiority or inferiority of these models is not completely elucidated. However, mixed irradiation is sometimes composed of more than two types of radiation, and for this type of mix...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.39.215
更新日期：1998-09-01 00:00:00
abstract：:We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...
journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
abstract：:The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...
journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：2014-03-01 00:00:00
abstract：:Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...
journal_title：Journal of radiation research
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doi：10.1093/jrr/rrt140
更新日期：2014-05-01 00:00:00
abstract：:To clarify the nature of the genes that contribute to the radiosensitivity of human hematopoietic stem/progenitor cells (HSPCs), we analyzed the gene expression profiles detected in HSPCs irradiated with 2 Gy X-rays after culture with or without an optimal combination of hematopoietic cytokines. Highly purified CD34(+...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrv071
更新日期：2016-01-01 00:00:00
abstract：:We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...
journal_title：Journal of radiation research
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更新日期：2012-09-01 00:00:00
abstract：:Non-homologous end-joining (NHEJ) is the predominant pathway for the repair of DNA double-strand breaks (DSBs) in human cells. XRCC4 is indispensable to NHEJ and functions together with DNA ligase IV in the rejoining of broken DNA ends. Artemis is a nuclease required for trimming of some, but not all, types of broken ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10168
更新日期：2011-01-01 00:00:00
abstract：:A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrt041
更新日期：2013-07-01 00:00:00
abstract：:This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All g...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrv009
更新日期：2015-05-01 00:00:00
abstract：:The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...
journal_title：Journal of radiation research
pub_type： 杂志文章
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更新日期：2016-07-01 00:00:00
abstract：:Patient A who was exposed to a critical dose of radiation developed skin lesions throughout the body surface, gastrointestinal disorder with massive diarrhea and prominent bleeding, which caused severe loss in body fluids. Gastrointestinal bleeding due to the deteriorated intestinal mucosa was considered to be one of ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.42.s167
更新日期：2001-09-01 00:00:00
abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.41.s31
更新日期：2000-10-01 00:00:00
abstract：:Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10036
更新日期：2010-01-01 00:00:00
abstract：:Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rry085
更新日期：2019-01-01 00:00:00
abstract：:Male C3H/HeN mice were exposed to 252Cf radiation and mated with unirradiated C57BL/6N females. F1 mice were analyzed for germline mutation at the paternally derived C3H/HeN allele of a hypervariable minisatellite locus, Ms6hm. This locus exhibited a high frequency of length change mutation spontaneously, and the muta...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.37.217
更新日期：1996-09-01 00:00:00
abstract：:While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...
journal_title：Journal of radiation research
pub_type： 杂志文章,评审
doi：10.1269/jrr.38.179
更新日期：1997-09-01 00:00:00
abstract：:The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrt032
更新日期：2013-09-01 00:00:00
abstract：:The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrt108
更新日期：2014-03-01 00:00:00
abstract：:The effectiveness of an Electronic Personal Dosemeter (Siemens EPD) for cosmic-radiation dosimetry at aviation altitudes was examined on eight international flights between March and September, 1998. The EPD values (Hepd) of the dose equivalent from penetrating radiation, Hp(10), were assumed to be almost the same as ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.42.57
更新日期：2001-03-01 00:00:00
abstract：:In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...
journal_title：Journal of radiation research
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
abstract：:Estimation of the relative biological effectiveness (RBE) of the proton beam at the National Cancer Center Proton Therapy Center in Korea (NCCPTC) is required clinically for the treatment of cancer. The proton beam was fixed at 190 MeV with 6 cm a spread out Bragg peaks (SOBP) for which corresponds to most frequent cl...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.08017
更新日期：2008-09-01 00:00:00
abstract：:The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.47.69
更新日期：2006-03-01 00:00:00
abstract：:The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using t...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rraa120
更新日期：2021-01-01 00:00:00
abstract：:The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrx030
更新日期：2017-11-01 00:00:00
abstract：:Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrs014
更新日期：2012-07-01 00:00:00
abstract：:Six Japanese patients in Hokkaido area were diagnosed as xeroderma pigmentosum (XP) at two University Hospital; one patient, a 29 years old female (XP2AS) at Asahikawa Medical College, and five patients, namely, a 53 years old male (XP1SA), a 45 years old female (XP2SA), a 46 years old female (XP3SA), a 47 years old m...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.35.168
更新日期：1994-09-01 00:00:00
abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.44.117
更新日期：2003-06-01 00:00:00
abstract：:This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out the...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.47.135
更新日期：2006-06-01 00:00:00
abstract：:The purpose of the study was to quantify local setup errors and evaluate the planning target volume (PTV) margins for sub-regions in cone-beam computed tomography (CBCT)-guided post-mastectomy radiation therapy (PMRT). The local setup errors of 20 patients undergoing CBCT-guided PMRT were analysed retrospectively. Ima...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rraa007
更新日期：2020-05-22 00:00:00
abstract：:Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...
journal_title：Journal of radiation research
pub_type： 杂志文章,评审
doi：10.1093/jrr/rrv013
更新日期：2015-05-01 00:00:00
