Abstract:
:While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded the checkpoint concept to mammalian cells. The growing list of p53-activating factors ranges from genotoxic agents to non-genotoxic stresses. The diverse involvement of p53 and its close linkage to other nuclear and extranuclear signaling networks force us to reconsider the concept of cellular stress response. A signaling network emerges from crosstalks between different types of stress in the same signaling pathway and crosstalks between different pathways in response to the same stress. We review the present knowledge on cellular stress signaling with emphasis on the crosstalks between different pathways and the molecules which mediate these crosstalks and offer our concept of signaling checkpoints. The importance of stress signaling checkpoints in cancer evolution and cancer therapy is also discussed.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Wang X,Ohnishi Tdoi
10.1269/jrr.38.179subject
Has Abstractpub_date
1997-09-01 00:00:00pages
179-94issue
3eissn
0449-3060issn
1349-9157journal_volume
38pub_type
杂志文章,评审abstract::Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and...
journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2016-07-01 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:Journal of radiation research
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pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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journal_title:Journal of radiation research
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更新日期:2017-01-01 00:00:00
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更新日期:2008-05-01 00:00:00
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更新日期:2011-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:1990-06-01 00:00:00
abstract::Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...
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pub_type: 杂志文章
doi:10.1269/jrr.07100
更新日期:2008-05-01 00:00:00
abstract::In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.0625
更新日期:2007-01-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
abstract::To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s261
更新日期:2002-12-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.361
更新日期:2002-12-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2020-09-08 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2020-03-23 00:00:00
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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更新日期:1996-09-01 00:00:00
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更新日期:2019-07-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2003-12-01 00:00:00
abstract::Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...
journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2017-05-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Journal of radiation research
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
abstract::In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09050
更新日期:2009-09-01 00:00:00