Abstract:
:We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment response on prognosis. Sixty-five patients treated between January 1998 and December 2008, and whose follow-up duration was more than 2 years were included. The Response Evaluation Criteria in Solid Tumors (version 1.1) was used for the evaluation of treatment. Median age was 59 years (range 21-83 years). Olfactory neuroblastoma (n = 20, 30%) and squamous cell carcinoma (n = 15, 23%) were the major pathological tumor types. The median follow-up duration was 51.6 months. Radiological response evaluation within 6 months after treatment demonstrated that 15% of the patients achieved complete response (CR), and 3-year progression free survival rates of all patients was 49.2%. The 3-year PFS rates according to response for the treatment were 55.6% in the patients with CR and 46.4% in those with non-CR, respectively (P = 0.643). However, the 3-year PFS rates were 80.% in the patients with CR and 10.% in those with non-CR (P = 0.051) in the patients with squamous cell carcinoma (SCC) histology. Radiological response evaluation within 6 months did not have a significant impact on prognosis when analysis included all histology, although early radiological response within 6 months after RT had a borderline significant impact on treatment outcomes for the patients with nasal and paranasal SCC.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Hojo H,Zenda S,Akimoto T,Kohno R,Kawashima M,Arahira S,Nishio T,Tahara M,Hayashi R,Sasai Kdoi
10.1093/jrr/rrs021subject
Has Abstractpub_date
2012-09-01 00:00:00pages
704-9issue
5eissn
0449-3060issn
1349-9157pii
rrs021journal_volume
53pub_type
杂志文章abstract::Investigating the biological effects of high-LET heavy-ion irradiation at low fluence is important to evaluate the risk of radiation in space. It is especially necessary to detect radiation damage induced by a precise number of heavy ions in individual cells. We thus compared the number of ions traversing a cell and t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s153
更新日期:2002-12-01 00:00:00
abstract::Several studies have reported the usefulness of the field-in-field (FIF) technique in breast radiotherapy. However, the methods for the FIF technique used in these studies vary. These methods were classified into three categories. We simulated a radiotherapy plan with each method and analyzed the outcomes. In the firs...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt233
更新日期:2014-07-01 00:00:00
abstract::The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.s31
更新日期:2000-10-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10036
更新日期:2010-01-01 00:00:00
abstract::The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs084
更新日期:2013-03-01 00:00:00
abstract::We examined the effect of whole body low-dose gamma-irradiation on the status of the antioxidant defense system in the rodent kidneys at different time intervals. Young male Balb/c mice were exposed to whole body radiation from a (60)Co source at doses of 10, 25 and 50 cGy (48.78 cGy/min). Antioxidant status and lipid...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06063
更新日期:2007-03-01 00:00:00
abstract::Modern treatment machines have shown small inter-unit variability regarding beam data. Recently, vendor-provided average beam data, such as the Representative Beam Data (RBD) of the TrueBeam (Varian Medical Systems, Palo Alto, CA, USA), has been used for modeling of the Eclipse (Varian Medical Systems) treatment plann...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrz082
更新日期:2020-03-23 00:00:00
abstract::Coal, fly ash and bottom ash samples were taken from a 300-MWe coal-fired power plant with a daily coal consumption of 2400 tons. A high volume sampler coupled with several mesh testing sieves was used to separate fly ash samples into different size fractions. Determination of the concentrations of 40K, 238U, 226Ra, 2...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.141
更新日期:1992-06-01 00:00:00
abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry107
更新日期:2019-03-01 00:00:00
abstract::To analyze the biological effects of the space environment, we flew nine lines of rice seeds on the Chinese 20(th) recoverable satellite for a duration of 18 days. The same lines of seeds were also irradiated to low doses (2.0 mGy) of Carbon, or Neon or Iron ions (with different LET value of 13.3 keV/microm, 31 keV/mi...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.0613
更新日期:2006-11-01 00:00:00
abstract::Due to the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident, the evacuees from Namie Town still cannot reside in the town, and some continue to live in temporary housing units. In this study, the radon activity concentrations were measured at temporary housing facilities, apartments and detached houses in Fukush...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv102
更新日期:2016-07-01 00:00:00
abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.389
更新日期:1991-12-01 00:00:00
abstract::Radiation therapy (RT) has become particularly important recently for treatment of liver tumors, but there are few experimental investigations pertaining to radiation-induced liver injuries over long-term follow-up periods. Thus, the present study examined pathological liver features over a 10-month period using an in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru005
更新日期:2014-07-01 00:00:00
abstract::The purpose of the present study was to develop a hybrid magnetic resonance/computed tomography (MR/CT)-compatible phantom and tissue-equivalent materials for each MR and CT image. Therefore, the essential requirements necessary for the development of a hybrid MR/CT-compatible phantom were determined and the developme...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz094
更新日期:2020-03-23 00:00:00
abstract::Paired Fricke solutions, made up from light water or heavy water and 0.8N in H2SO4 and 1 mM in Fe(NH4)2(SO4)2 and NaCl, were calibrated with 60Co gamma rays and with mixed neutron and gamma radiation from a 252Cf source. Absorbance increases, AL and AH, in light- and heavy-water Fricke dosimeters, respectively, increa...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.37.97
更新日期:1996-06-01 00:00:00
abstract::The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv099
更新日期:2016-03-01 00:00:00
abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt108
更新日期:2014-03-01 00:00:00
abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_310
更新日期:1991-03-01 00:00:00
abstract::The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.301
更新日期:1992-12-01 00:00:00
abstract::Six Japanese patients in Hokkaido area were diagnosed as xeroderma pigmentosum (XP) at two University Hospital; one patient, a 29 years old female (XP2AS) at Asahikawa Medical College, and five patients, namely, a 53 years old male (XP1SA), a 45 years old female (XP2SA), a 46 years old female (XP3SA), a 47 years old m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.168
更新日期:1994-09-01 00:00:00
abstract::This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs050
更新日期:2012-11-01 00:00:00
abstract::A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt041
更新日期:2013-07-01 00:00:00
abstract::The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw075
更新日期:2016-09-01 00:00:00
abstract::Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was igno...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_154
更新日期:1991-03-01 00:00:00
abstract::Brain metastasis from esophageal carcinoma has been considered rare and survival following esophageal carcinoma with distant metastasis is poor. The purpose of this report was to clarify cumulative incidence and risk factors for brain metastasis after chemoradiotherapy for esophageal carcinoma, and to consider recomme...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10184
更新日期:2011-01-01 00:00:00
abstract::Irregular breathing can influence the outcome of 4D computed tomography imaging and cause artifacts. Visual biofeedback systems associated with a patient-specific guiding waveform are known to reduce respiratory irregularities. In Japan, abdomen and chest motion self-control devices (Abches) (representing simpler visu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv106
更新日期:2016-07-01 00:00:00
abstract::Radiation-induced rescue effect (RIRE) in cells refers to the phenomenon where irradiated cells (IRCs) receive help from feedback signals produced by partnered bystander unirradiated cells (UIRCs) or from the conditioned medium (CM) that has previously conditioned the UIRCs. In the present work, we explored the role o...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa023
更新日期:2020-05-22 00:00:00
abstract::Although radon inhalation increases superoxide dismutase (SOD) activities in mouse organs, the mechanisms and pathways have not yet been fully clarified. The aim of this study was to determine the details of SOD activation in mouse brain tissue following the inhalation of radon at concentrations of 500 or 2000 Bq/m3 f...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx048
更新日期:2017-11-01 00:00:00
abstract::Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness of proton beam therapy (PBT) using a patch-field technique for large HCC. Data from nine patients (aged 52-79 years) with large HCC tr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry056
更新日期:2018-09-01 00:00:00