Abstract:
:The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that in air. The present study focused on such a situation in order to better understand the biokinetics of radon. To mathematically express the entry of radon through the skin into the body, we first modified the latest sophisticated biokinetic model for noble gases. Values of an important parameter for the model-the skin permeability coefficient K (m s(-1))-were derived using data from previous human studies. The analysis of such empirical data, which corresponded to radon concentrations in the air exhaled by subjects during and following bathing in radon-rich thermal water, revealed that the estimated K values had a log-normal distribution. The validity of the K values and the characteristics of the present model are then discussed. Furthermore, the impact of the intake of radon or its progeny via inhalation or skin absorption on radiation dose was also assessed for possible exposure scenarios in a radon hot spring. It was concluded that, depending on the radon concentration in thermal water, there might be situations in which the dose contribution resulting from skin absorption of radon is comparable to that resulting from inhalation of radon and its progeny. This conclusion can also apply to other therapeutic situations (e.g. staying in the pool for a longer period).
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Sakoda A,Ishimori Y,Tschiersch Jdoi
10.1093/jrr/rrw024subject
Has Abstractpub_date
2016-07-01 00:00:00pages
336-42issue
4eissn
0449-3060issn
1349-9157pii
rrw024journal_volume
57pub_type
杂志文章abstract::Direct irradiation may cause malfunctioning of cardiac implantable electronic devices (CIEDs). Therefore, a treatment plan that does not involve direct irradiation of CIEDs should be formulated. However, CIEDs may be directly exposed to radiation because of the sudden intrafractional movement of the patient. The proba...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa016
更新日期:2020-05-22 00:00:00
abstract::The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw075
更新日期:2016-09-01 00:00:00
abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry107
更新日期:2019-03-01 00:00:00
abstract::The radioprotective effect of hawthorn (Crataegus microphylla) fruit extract against genotoxicity induced by gamma irradiation has been investigated in mouse bone marrow cells. A single intraperitoneal (ip) administration of hawthorn extract at doses of 25, 50, 100 and 200 mg/kg 1h prior to gamma irradiation (2 Gy) re...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.06032
更新日期:2007-01-01 00:00:00
abstract::Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole bod...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.127
更新日期:2004-03-01 00:00:00
abstract::We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt081
更新日期:2014-01-01 00:00:00
abstract::The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10116
更新日期:2011-01-01 00:00:00
abstract::Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.267
更新日期:1991-09-01 00:00:00
abstract::Carbon-ion therapy by layer-stacking irradiation for static targets has been practised in clinical treatments. In order to apply this technique to a moving target, disturbances of carbon-ion dose distributions due to respiratory motion have been studied based on the measurement using a respiratory motion phantom, and ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx001
更新日期:2017-11-01 00:00:00
abstract::The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of w...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_231
更新日期:1991-03-01 00:00:00
abstract::A biological dosimetry system for measuring solar UV-B light was established using bacteriophage T1 with E. coli Bs-1 as the host cell. Also a new physical UV-B dosimeter was developed which can specifically detect the UV spectral region related to inactivation of phage T1. Phage T1 is very stable in liquid suspension...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.189
更新日期:1990-06-01 00:00:00
abstract::In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10185
更新日期:2011-01-01 00:00:00
abstract::In vivo laboratory experiments on tritium gas (HT) fixation in pine trees were conducted using one-way circuit inhalation apparatus and dwarf pine trees. After 2 hours of exposure to HT, tritium distribution in pine needles, branches, trunk, roots and soil was measured. The specific activity of tritium in pine needles...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.30.330
更新日期:1989-12-01 00:00:00
abstract::The present paper reports and discusses the results concerning both the inter- and intrafraction accuracy achievable combining the immobilization system employed in patients with head-and-neck, brain and skull base tumors with image guidance at our particle therapy center. Moreover, we investigated the influence of in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt038
更新日期:2013-07-01 00:00:00
abstract::The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.s31
更新日期:2000-10-01 00:00:00
abstract::We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.40.s21
更新日期:1999-12-01 00:00:00
abstract::Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa044
更新日期:2020-07-06 00:00:00
abstract::Previous studies have demonstrated that X-ray irradiation affects angiogenesis in tumors. Here, we studied the effects of gamma-ray irradiation on boron-10 compound accumulation in a murine tumor model. The mouse squamous cell carcinoma was irradiated with gamma-ray before BSH ((10)B-enriched borocaptate sodium) admin...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.09071
更新日期:2009-11-01 00:00:00
abstract::The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s53
更新日期:2002-12-01 00:00:00
abstract::The purpose of this study was to quantify the changes of tumor blood flow (BF) in cervical cancer after radiation therapy by using perfusion computed tomography (CT), and to examine the difference between maximum slope (MS) and single-input one-compartment model (SOCM) methods. Fourteen consecutive patients who receiv...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11079
更新日期:2011-01-01 00:00:00
abstract::An overview is given of the dose-response relationship for stable chromosome aberrations (i.e., translocations and inversions) in the peripheral blood lymphocytes of A-bomb survivors in Hiroshima. Special emphasis is placed on (i) the overdispersion of survivor cases with either unexpectedly high or low aberration fre...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.33.supplement_206
更新日期:1992-03-01 00:00:00
abstract::Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coi...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09012s
更新日期:2009-03-01 00:00:00
abstract::The physico-chemical form in which plutonium enters the body influences the lung distribution and the transfer rate from lungs to blood. In the present study, we evaluated the early lung damage and macrophage activation after pulmonary contamination of plutonium of various preparation modes which produce different sol...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11112
更新日期:2012-01-01 00:00:00
abstract::Boron neutron capture therapy (BNCT) is an emerging radiation treatment modality, exhibiting the potential to selectively destroy cancer cells. Currently, BNCT is conducted using a nuclear reactor. However, the future trend is to move toward an accelerator-based system for use in hospital environments. A typical BNCT ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz101
更新日期:2020-03-23 00:00:00
abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx088
更新日期:2018-05-01 00:00:00
abstract::To evaluate the lifetime hazards of ionizing radiation exposure, 1680 beagles received whole-body, 60-Cobalt gamma exposures or sham-exposures during development. Eight groups of 120 dogs each received mean doses of 16 or 83 cGy at 8 (preimplantation), 28 (embryonic), or 55 (late fetal) days postcoitus (dpc), or 2 (ne...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement2_86
更新日期:1991-12-01 00:00:00
abstract::We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs021
更新日期:2012-09-01 00:00:00
abstract::This study determined whether dynamic F-18 FDG PET imaging could differentiate benign from malignant solitary pulmonary nodules (SPNs). Histopathologically confirmed SPNs (10-35 mm), 24 malignant and 10 benign, from 34 patients were studied through both dynamic and static F-18 FDG PET imaging of all patients. Volumes ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11089
更新日期:2012-01-01 00:00:00
abstract::While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.38.179
更新日期:1997-09-01 00:00:00
abstract::Radiation therapy (RT) has become particularly important recently for treatment of liver tumors, but there are few experimental investigations pertaining to radiation-induced liver injuries over long-term follow-up periods. Thus, the present study examined pathological liver features over a 10-month period using an in...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru005
更新日期:2014-07-01 00:00:00