Abstract:
:Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coincided with major changes in our understanding of how radiation interacts with cells. In particular, the evidence that bystander responses occur, where cells not directly irradiated can respond to irradiated neighbours, has brought about the evolution of new models of radiation response. Although these processes have been studied using a range of experimental approaches, microbeams offer a unique route by which bystander responses can be elucidated. Without exception, all of the microbeams currently active internationally have studied bystander responses in a range of cell and tissue models. Together these studies have considerably advanced our knowledge of bystander responses and the underpinning mechanisms. Much of this has come from charged particle microbeam studies, but increasingly, X-ray and electron microbeams are starting to contribute quantitative and mechanistic information on bystander effects. A recent development has been the move from studies with 2-D cell culture models to more complex 3-D systems where the possibilities of utilizing the unique characteristics of microbeams in terms of their spatial and temporal delivery will make a major impact.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Prise KM,Schettino G,Vojnovic B,Belyakov O,Shao Cdoi
10.1269/jrr.09012ssubject
Has Abstractpub_date
2009-03-01 00:00:00pages
A1-6eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/09012Sjournal_volume
50 Suppl Apub_type
杂志文章,评审abstract::Efficacy of different schedules of HDR brachytherapy in concurrent chemoradiotherapy was evaluated. The study compared the effectiveness of the two HDR brachytherapy schedules which have the same Biological Effective Dose (BED) in locally advanced cervical carcinoma that was treated with concurrent chemoradiotherapy. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,随机对照试验
doi:10.1269/jrr.11038
更新日期:2012-01-01 00:00:00
abstract::Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09039
更新日期:2009-07-01 00:00:00
abstract::In patients with various cancers, modified Glasgow prognostic score (mGPS) before treatment has predicted prognoses after antitumor therapy. This study aimed to assess whether pretreatment mGPS also has predictive value in patients with muscle-invasive bladder cancer (MIBC) after radiotherapy. A retrospective review a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa039
更新日期:2020-07-06 00:00:00
abstract::The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s53
更新日期:2002-12-01 00:00:00
abstract::This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.38.45
更新日期:1997-03-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common progressive and irreversible neurodegenerative disease and it is caused by neuronal death in the brain. Recent studies have shown that non-ionizing radiofrequency (RF) radiation has some beneficial cognitive effects in animal models of AD. In this study, we examined the effe...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw040
更新日期:2016-11-01 00:00:00
abstract::PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms of tumor-specific radiosensitizat...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw054
更新日期:2016-09-01 00:00:00
abstract::The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz042
更新日期:2019-10-23 00:00:00
abstract::Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry085
更新日期:2019-01-01 00:00:00
abstract::Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs014
更新日期:2012-07-01 00:00:00
abstract::Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10036
更新日期:2010-01-01 00:00:00
abstract::The physico-chemical form in which plutonium enters the body influences the lung distribution and the transfer rate from lungs to blood. In the present study, we evaluated the early lung damage and macrophage activation after pulmonary contamination of plutonium of various preparation modes which produce different sol...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11112
更新日期:2012-01-01 00:00:00
abstract::A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.361
更新日期:2001-12-01 00:00:00
abstract::Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to 239PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeare...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.301
更新日期:2002-09-01 00:00:00
abstract::The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.s31
更新日期:2000-10-01 00:00:00
abstract::We previously showed that free radicals and oxidative stress are involved in radiation-induced skin reactions. Since vitamin E (VE) is a particularly important lipophilic antioxidant, VE-deficient mice were used to examine its effects on radiation-induced skin damage. The VE content of the skin was reduced to one four...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10042
更新日期:2011-01-01 00:00:00
abstract::To improve treatment conformity for prostate cancer, we investigated daily applicator displacement during high-dose-rate interstitial brachytherapy (HDR-ISBT). Thirty patients treated with HDR-ISBT as monotherapy were examined. All patients received a treatment dosage of 49 Gy per 7 fractions over 4 days. For dose adm...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:
更新日期:2012-01-01 00:00:00
abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru093
更新日期:2015-01-01 00:00:00
abstract::Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.116
更新日期:1994-06-01 00:00:00
abstract::Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clini...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry033
更新日期:2018-05-01 00:00:00
abstract::A biological dosimetry system for measuring solar UV-B light was established using bacteriophage T1 with E. coli Bs-1 as the host cell. Also a new physical UV-B dosimeter was developed which can specifically detect the UV spectral region related to inactivation of phage T1. Phage T1 is very stable in liquid suspension...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.189
更新日期:1990-06-01 00:00:00
abstract::Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.07100
更新日期:2008-05-01 00:00:00
abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry107
更新日期:2019-03-01 00:00:00
abstract::Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw106
更新日期:2017-03-01 00:00:00
abstract::Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru079
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to analyze the dosimetry and investigate the clinical outcomes of radiation-induced rib fractures (RIRFs) after stereotactic body radiotherapy (SBRT). A total of 126 patients with Stage I primary lung cancer treated with SBRT, who had undergone follow-up computed tomography (CT) at least ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru107
更新日期:2015-03-01 00:00:00
abstract::In vivo laboratory experiments on tritium gas (HT) fixation in pine trees were conducted using one-way circuit inhalation apparatus and dwarf pine trees. After 2 hours of exposure to HT, tritium distribution in pine needles, branches, trunk, roots and soil was measured. The specific activity of tritium in pine needles...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.30.330
更新日期:1989-12-01 00:00:00
abstract::XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv086
更新日期:2016-03-01 00:00:00
abstract::Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyz...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru120
更新日期:2015-05-01 00:00:00
abstract::The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.08066
更新日期:2009-01-01 00:00:00