Abstract:
:The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal human glial cell line, SVGp12, using DNA microarray. Microarray analysis revealed 23 assigned gene spots and 5 non-assigned gene spots as prospective altered gene spots. Twenty-two genes out of the 23 assigned gene spots were further analyzed by reverse transcription-polymerase chain reaction to validate the results of microarray, and no significant alterations in gene expression were observed. Under the experimental conditions used in this study, we found no evidence that exposure to RF fields affected gene expression in SVGp12 cells.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Sakurai T,Kiyokawa T,Narita E,Suzuki Y,Taki M,Miyakoshi Jdoi
10.1269/jrr.10116subject
Has Abstractpub_date
2011-01-01 00:00:00pages
185-92issue
2eissn
0449-3060issn
1349-9157pii
JST.JSTAGE/jrr/10116journal_volume
52pub_type
杂志文章abstract::Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.255
更新日期:2003-09-01 00:00:00
abstract::Intrafractional motion and interfractional changes affect the accuracy of the delivered dose in radiotherapy, particularly in charged-particle radiotherapy. Most recent studies are focused on intrafractional motion (respiratory motion). Here, we report a quantitative simulation analysis of the effects of interfraction...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.09032
更新日期:2009-11-01 00:00:00
abstract::Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt140
更新日期:2014-05-01 00:00:00
abstract::We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt081
更新日期:2014-01-01 00:00:00
abstract::Pericardial effusion is an important late toxicity after concurrent chemoradiotherapy (CCRT) for locally advanced esophageal cancer. We investigated the clinical and dosimetric factors that were related to pericardial effusion among patients with thoracic esophageal cancer who were treated with definitive CCRT using t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry029
更新日期:2018-05-01 00:00:00
abstract::In our previous studies, we found that low-dose radiation inhibits oxidative stress-induced diseases due to increased antioxidants. Although these effects of low-dose radiation were demonstrated, further research was needed to clarify the effects. However, the analysis of oxidative stress is challenging, especially th...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw083
更新日期:2017-01-01 00:00:00
abstract::We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...
journal_title:Journal of radiation research
pub_type: 历史文章,杂志文章
doi:10.1269/jrr.47.b31
更新日期:2006-01-01 00:00:00
abstract::Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10036
更新日期:2010-01-01 00:00:00
abstract::X-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the ef...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.34.285
更新日期:1993-12-01 00:00:00
abstract::This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and the dose-volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed the data of 83 patients with esophageal cancer treated using definitive...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa001
更新日期:2020-03-23 00:00:00
abstract::This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw043
更新日期:2016-11-01 00:00:00
abstract::We investigated the sensitizing effect of the 2-nitroimidazole analogue doranidazole, a new hypoxic radiosensitizer, on radiation-induced apoptosis in L5178Y cells. Apoptosis was assessed by checking DNA ladder formation, the presence of sub-G1 peaks in flow cytometry, and chromatin condensation. A radiosensitizing ef...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.161
更新日期:2002-06-01 00:00:00
abstract::In patients with various cancers, modified Glasgow prognostic score (mGPS) before treatment has predicted prognoses after antitumor therapy. This study aimed to assess whether pretreatment mGPS also has predictive value in patients with muscle-invasive bladder cancer (MIBC) after radiotherapy. A retrospective review a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa039
更新日期:2020-07-06 00:00:00
abstract::The purpose of this study was to quantify the changes of tumor blood flow (BF) in cervical cancer after radiation therapy by using perfusion computed tomography (CT), and to examine the difference between maximum slope (MS) and single-input one-compartment model (SOCM) methods. Fourteen consecutive patients who receiv...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.11079
更新日期:2011-01-01 00:00:00
abstract::The rejoining efficiency of double-strand breaks (DSBs) was quantified by a DNA fragment-size analysis in tobacco protoplasts and CHO-K1 cells following gamma-ray irradiation in order to compare DNA reparability of higher plants with mammals. Results showed that the DSB rejoining efficiency of tobacco protoplasts is d...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.08064
更新日期:2009-03-01 00:00:00
abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.389
更新日期:1991-12-01 00:00:00
abstract::The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.301
更新日期:1992-12-01 00:00:00
abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt061
更新日期:2013-11-01 00:00:00
abstract::A series of experiments was carried out using female (C57BL/6N x C3H/He)F1 mice (BCF1) to assess the carcinogenic effect of tritiated water (HTO) following a preliminary experiment in which the acute effect of HTO was studied in young female mice of C57BL/6L strain in an attempt to gain basic information on the long-t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement2_132
更新日期:1991-12-01 00:00:00
abstract::To gain an insight into the relationship between UVB-carcinogenesis and natural killer activity, we examined ultraviolet light-induced carcinogenesis in mice with high natural killer, activity (KSN) and mice with natural killer deficiency (KSN-bg). We exposed mice six times a week to three levels of daily ultraviolet ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.39.119
更新日期:1998-06-01 00:00:00
abstract::Non-homologous end-joining (NHEJ) is the predominant pathway for the repair of DNA double-strand breaks (DSBs) in human cells. XRCC4 is indispensable to NHEJ and functions together with DNA ligase IV in the rejoining of broken DNA ends. Artemis is a nuclease required for trimming of some, but not all, types of broken ...
journal_title:Journal of radiation research
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更新日期:2011-01-01 00:00:00
abstract::Spatial distributions of soil contamination by 137Cs (89 sampling points) and 239+240Pu (76 points) near and within Dolon village were analyzed. An essential exponential decrease of contamination was found in Dolon village: the distance of a half reduction in contamination is about 0.87-1.25 km (in a northwest-southea...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.47.a149
更新日期:2006-02-01 00:00:00
abstract::This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs050
更新日期:2012-11-01 00:00:00
abstract::To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1269/jrr.45.269
更新日期:2004-06-01 00:00:00
abstract::This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for ge...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1269/jrr.46.135
更新日期:2005-06-01 00:00:00
abstract::The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.46.215
更新日期:2005-06-01 00:00:00
abstract::In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09050
更新日期:2009-09-01 00:00:00
abstract::Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry085
更新日期:2019-01-01 00:00:00
abstract::This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw053
更新日期:2016-09-01 00:00:00
abstract::The aims of present study were to evaluate the efficacy of combining sunitinib with ionizing radiation (IR) on endothelial cells in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to IR with or without sunitinib pretreatment. Apoptosis assay and cell cycle distribution were analyzed by ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10013
更新日期:2011-01-01 00:00:00