当前位置： SCI文献检索 > JOURNAL OF RADIATION RESEARCH期刊下所有文献 > Differential activation of kinases in ex vivo and in vivo irradiated mice lymphocytes.

Differential activation of kinases in ex vivo and in vivo irradiated mice lymphocytes.

Abstract：

:Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole body irradiation is concerned. In this study a comparison has been made between the activities of these kinases following ex vivo and in vivo irradiation. Tyrosine kinase activity showed no difference in the lymphocytes irradiated ex vivo or in vivo. A significant differential dose-dependent response could be observed in PKC activity. PKC was seen to be activated at the higher dose, i.e., 1 Gy in, in vivo irradiated lymphocytes, whereas in ex vivo irradiated lymphocytes, PKC was seen to be activated at the lower dose, i.e., 0.1 Gy. MAP kinase activity was seen to decrease with an increasing dose in ex vivo irradiated lymphocytes. In vivo MAP kinase activity was seen to increase as the dose increased, with maximum activation at 3 Gy. These kinases are being used to manipulate the tumor response to radiotherapy. Thus it is essential to study the behavior of the above kinases in the whole animal because the difference in response of a single cell to the whole animal may be different.

journal_name

J Radiat Res

journal_title

Journal of radiation research

authors

Varadkar PA,Krishna M

doi

10.1269/jrr.45.127

keywords:

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

127-31

issue

1

eissn

0449-3060

issn

1349-9157

journal_volume

45

pub_type

杂志文章

相关文献

JOURNAL OF RADIATION RESEARCH文献大全
  • Three-dimensional dose prediction and validation with the radiobiological gamma index based on a relative seriality model for head-and-neck IMRT.

    abstract：:This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrx017

    authors： Hamatani N,Sumida I,Takahashi Y,Oda M,Seo Y,Isohashi F,Tamari K,Ogawa K

    更新日期：2017-09-01 00:00:00

  • Alpha-particle fluence in radiobiological experiments.

    abstract：:Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrw106

    authors： Nikezic D,Yu KN

    更新日期：2017-03-01 00:00:00

  • Kinetic analysis of double-strand break rejoining reveals the DNA reparability of gamma-irradiated tobacco cultured cells.

    abstract：:The rejoining efficiency of double-strand breaks (DSBs) was quantified by a DNA fragment-size analysis in tobacco protoplasts and CHO-K1 cells following gamma-ray irradiation in order to compare DNA reparability of higher plants with mammals. Results showed that the DSB rejoining efficiency of tobacco protoplasts is d...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.08064

    authors： Yokota Y,Wada S,Hase Y,Funayama T,Kobayashi Y,Narumi I,Tanaka A

    更新日期：2009-03-01 00:00:00

  • Effects of neonatal ovarian X-irradiation in the Chinese hamster. I. Correlation between the age of irradiation and the fertility span.

    abstract：:The fertility span between the first and the last estrus was compared among female Chinese hamsters exposed to 1 Gy X-rays on neonatal day 0, 2, 4, 6, 8, 10 and 14. The fertility span changed dramatically according to the age at the time of irradiation. The females irradiated on day 4, 6 and 8 showed a definite delay ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.30.185

    authors： Tateno H,Mikamo K

    更新日期：1989-06-01 00:00:00

  • Cancer mortality in the high background radiation areas of Yangjiang, China during the period between 1979 and 1995.

    abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.41.s31

    authors： Tao Z,Zha Y,Akiba S,Sun Q,Zou J,Li J,Liu Y,Kato H,Sugahara T,Wei L

    更新日期：2000-10-01 00:00:00

  • Hypoxia expression in radiation-induced late rectal injury.

    abstract：:Tumor hypoxia and angiogenesis have been studied extensively. However, the relation between normal tissue injury and hypoxia is still unclear. In this study, we investigated the effect of hypoxia on radiation-induced late rectal injury in mice. The rectum of C57BL/6N mice was irradiated locally with a single dose of 2...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.07099

    authors： Liu Y,Kudo K,Abe Y,Aoki M,Hu DL,Kijima H,Nakane A

    更新日期：2008-05-01 00:00:00

  • Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.

    abstract：:When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.s209

    authors： Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

    更新日期：2002-12-01 00:00:00

  • 4D digitally reconstructed radiography for verifying a lung tumor position during volumetric modulated arc therapy.

    abstract：:We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrs013

    authors： Nakagawa K,Kida S,Haga A,Masutani Y,Yamashita H,Onoe T,Imae T,Tanaka K,Ohtomo K,Yoda K

    更新日期：2012-07-01 00:00:00

  • Reassessment of the cancer mortality risk among Hiroshima atomic-bomb survivors using a new dosimetry system, ABS2000D, compared with ABS93D.

    abstract：:The aim of the present study was to examine the excess relative risk for leukemia mortality and all cancers, except leukemia, among Hiroshima atomic-bomb survivors by applying ABS93D and ABS2000D. Particular attention was given to any difference in the neutron-dose estimates between the two dosimetry systems. The stud...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.53

    authors： Katayama H,Matsuura M,Endo S,Hoshi M,Ohtaki M,Hayakawa N

    更新日期：2002-03-01 00:00:00

  • Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.

    abstract：:Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line. Therefore, a ROS-i...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrs125

    authors： Hirose K,Monzen S,Sato H,Sato M,Aoki M,Hatayama Y,Kawaguchi H,Narita Y,Takai Y,Kashiwakura I

    更新日期：2013-05-01 00:00:00

  • Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells.

    abstract：:Resveratrol has received considerable attention as a polyphenol with anti-oxidant, anti-carcinogenic, and anti-inflammatory effects. Radiation is an important component of therapy for a wide range of malignant conditions. However, it causes damage to normal cells and, hence, can result in adverse side effects. This st...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrt140

    authors： Jeong MH,Yang KM,Jeong DH,Lee CG,Oh SJ,Jeong SK,Lee KW,Jo YR,Jo WS

    更新日期：2014-05-01 00:00:00

  • Hyaluronate gel injection for rectum dose reduction in gynecologic high-dose-rate brachytherapy: initial Japanese experience.

    abstract：:Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrz016

    authors： Kashihara T,Murakami N,Tselis N,Kobayashi K,Tsuchida K,Shima S,Masui K,Yoshida K,Takahashi K,Inaba K,Umezawa R,Igaki H,Ito Y,Kato T,Uno T,Itami J

    更新日期：2019-07-01 00:00:00

  • Recent innovations in carbon-ion radiotherapy.

    abstract：:In the last few years, hospital-based facilities for carbon-ion radiotherapy are being constructed and proposed in Europe and Asia. During the next few years, several new facilities will be opened for carbon-ion radiotherapy in the world. These facilities in operation or under construction are categorized in two types...

    journal_title：Journal of radiation research

    pub_type： 杂志文章,评审

    doi：10.1269/jrr.10028

    authors： Minohara S,Fukuda S,Kanematsu N,Takei Y,Furukawa T,Inaniwa T,Matsufuji N,Mori S,Noda K

    更新日期：2010-01-01 00:00:00

  • Rectal content and intrafractional prostate gland motion assessed by magnetic resonance imaging.

    abstract：:We evaluated the interrelationship between rectal content and intrafraction motion of the prostate. Forty seven prostate cancer patients instructed to remove their rectal gas were imaged by planning CT and MRI before radiotherapy (RT) and during RT. The total scan time was comparable to our cone-beam CT scanning and t...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.10126

    authors： Ogino I,Kaneko T,Suzuki R,Matsui T,Takebayashi S,Inoue T,Morita S

    更新日期：2011-01-01 00:00:00

  • High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines.

    abstract：:There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-D...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.361

    authors： Kumar KS,Srinivasan V,Toles RE,Miner VL,Jackson WE,Seed TM

    更新日期：2002-12-01 00:00:00

  • Effect of gamma-irradiation on the uptake and digestion of 125I-labeled bovine serum albumin by rat visceral yolk sac cultured in vitro.

    abstract：:The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.34.171

    authors： Takahashi S,Koshimoto C,Kubota Y

    更新日期：1993-06-01 00:00:00

  • The impact of epidermal growth factor receptor mutations on patterns of disease recurrence after chemoradiotherapy for locally advanced non-small cell lung cancer: a literature review and pooled analysis.

    abstract：:The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章,评审

    doi：10.1093/jrr/rrw075

    authors： Ochiai S,Nomoto Y,Watanabe Y,Yamashita Y,Toyomasu Y,Kawamura T,Takada A,Noriko,Sakuma H

    更新日期：2016-09-01 00:00:00

  • Stereotactic body radiation therapy for early-stage non-small-cell lung cancer in octogenarians and older: an alternative treatment.

    abstract：:Surgery is the standard modality for early-stage I-II non-small-cell lung cancer (NSCLC). Generally, patients who are >80 years old tend to have more comorbidities and inferior physical status than younger patients. Stereotactic body radiation therapy (SBRT) may provide an alternative treatment for this group of patie...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rraa027

    authors： Bei Y,Murakami N,Nakayama Y,Okuma K,Kashihara T,Raturi VP,Okamoto H,Takahashi K,Inaba K,Igaki H,Itami J

    更新日期：2020-07-06 00:00:00

  • Transfer of plutonium to rat embryos in vivo and in vitro.

    abstract：:The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.33.301

    authors： Takahashi S,Sato H,Kubota Y,Inaba J

    更新日期：1992-12-01 00:00:00

  • Analyses of local control and survival after stereotactic body radiotherapy for pulmonary oligometastases from colorectal adenocarcinoma.

    abstract：:This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rraa071

    authors： Yamamoto T,Niibe Y,Matsumoto Y,Onishi H,Aoki M,Nishikawa A,Oh RJ,Shintani T,Yahara K,Ozaki M,Manabe Y,Jingu K

    更新日期：2020-11-16 00:00:00

  • Multimodal approaches including three-dimensional conformal re-irradiation for recurrent or persistent esophageal cancer: preliminary results.

    abstract：:The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradi...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.11066

    authors： Yamaguchi S,Ohguri T,Imada H,Yahara K,Moon SD,Higure A,Yamaguchi K,Yoshikawa I,Harada M,Korogi Y

    更新日期：2011-01-01 00:00:00

  • Whole-pelvic radiotherapy with spot-scanning proton beams for uterine cervical cancer: a planning study.

    abstract：:The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrw052

    authors： Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

    更新日期：2016-09-01 00:00:00

  • Long-term exposure to a 40-GHz electromagnetic field does not affect genotoxicity or heat shock protein expression in HCE-T or SRA01/04 cells.

    abstract：:Millimeter waves are used in various fields, and the risks of this wavelength range for human health must be carefully evaluated. In this study, we investigated the effects of millimeter waves on genotoxicity and heat shock protein expression in human corneal epithelial (HCE-T) and human lens epithelial (SRA01/04) cel...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrz017

    authors： Koyama S,Narita E,Suzuki Y,Shiina T,Taki M,Shinohara N,Miyakoshi J

    更新日期：2019-07-01 00:00:00

  • A novel combination treatment of armed oncolytic adenovirus expressing IL-12 and GM-CSF with radiotherapy in murine hepatocarcinoma.

    abstract：:In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.10185

    authors： Kim W,Seong J,Oh HJ,Koom WS,Choi KJ,Yun CO

    更新日期：2011-01-01 00:00:00

  • Clinical outcomes for 61 cases of hypopharyngeal cancer with synchronous esophageal cancer.

    abstract：:The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrz042

    authors： Yang S,Yang S,Liao W,Huang R,Li B,Lu S,Li C,Wang Z,Li C,Pei J,Wen H,Zhang S

    更新日期：2019-10-23 00:00:00

  • Mutation induction and RBE of low energy neutrons in V79 cells.

    abstract：:We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.40.s21

    authors： Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

    更新日期：1999-12-01 00:00:00

  • Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model.

    abstract：:The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rrt108

    authors： Sanzari JK,Wan SX,Diffenderfer ES,Cengel KA,Kennedy AR

    更新日期：2014-03-01 00:00:00

  • Analysis of simultaneous modulated accelerated radiotherapy (SMART) for nasopharyngeal carcinomas.

    abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1093/jrr/rru012

    authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

    更新日期：2014-07-01 00:00:00

  • Exposure rate as a determinant of the synergistic interaction of heat combined with ionizing or ultraviolet radiation in cell killing.

    abstract：:A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.42.361

    authors： Kim JK,Petin VG,Zhurakovskaya GP

    更新日期：2001-12-01 00:00:00

  • Immunohistochemical study on cellular origins of rat lung tumors induced by inhalation exposures to plutonium dioxide aerosols as compared to those by X-ray irradiation.

    abstract：:Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to 239PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeare...

    journal_title：Journal of radiation research

    pub_type： 杂志文章

    doi：10.1269/jrr.43.301

    authors： Oghiso Y,Yamada Y

    更新日期：2002-09-01 00:00:00