High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines.

Abstract:

:There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-DC or the vehicle and exposed to 3.4 Gy or 4.1 Gy of 60Co radiation. Canines irradiated at 4.1 Gy were also given clinical support, which consisted of blood transfusion and antibiotics (gentamicin, and cefoxitin or cephalexin). Peripheral blood cell profile and 60-day survival were used as indices of protection. At 3.4 Gy, 3-DC- or vehicle-treated canines without postirradiation clinical support survived only for 10 to 12 days. Fifty percent of the canines treated with 3-DC or vehicle and provided postirradiation clinical support survived 4.1-Gy irradiation. Survival of canines treated with vehicle before irradiation significantly correlated with postirradiation antibiotic treatments, but not with blood transfusion. The recovery profile of peripheral blood cells in 4.1 Gy-irradiated canines treated with vehicle and antibiotics was better than drug-treated canines. These results indicate that therapy with high doses of intramuscular aminoglycoside antibiotic (gentamicin) and an oral cephalosporin (cephalexin) enhanced survival of irradiated canines. Although blood transfusion correlated with survival of 3-DC treated canines, there were no additional survivors with 3-DC treated canines than the controls.

journal_name

J Radiat Res

authors

Kumar KS,Srinivasan V,Toles RE,Miner VL,Jackson WE,Seed TM

doi

10.1269/jrr.43.361

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

361-70

issue

4

eissn

0449-3060

issn

1349-9157

journal_volume

43

pub_type

杂志文章
  • The role of the sympathetic nervous system in radiation-induced apoptosis in jejunal crypt cells of spontaneously hypertensive rats.

    abstract::To evaluate the effect of the sympathetic nervous system on radiation-induced apoptosis in jejunal crypt cells, apoptosis levels were compared in spontaneously hypertensive rats (SHR), animals which are a genetic hyperfunction model of the sympathetic nervous system, and normotensive Wistar-Kyoto rats (WKY). SHR and W...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.41.55

    authors: Matsuu M,Shichijo K,Nakamura Y,Ikeda Y,Naito S,Ito M,Okaichi K,Sekine I

    更新日期:2000-03-01 00:00:00

  • Neutron carcinogenesis: past, present, and future.

    abstract::An interest in the possible cancer causing ability of neutrons began soon after their discovery. Early use of neutrons from radioactive sources and from cyclotrons led to a need to define risk for such exposures. This need was soon followed by a more tangible need to define risk to the general population of high LET r...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.s117

    authors: Hill CK,Williams-Hill D

    更新日期:1999-12-01 00:00:00

  • Mutation induction and RBE of low energy neutrons in V79 cells.

    abstract::We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.s21

    authors: Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

    更新日期:1999-12-01 00:00:00

  • Chromosomal aberrations detected by chromosome painting in lymphocytes from cancer patients given high doses of therapeutic X-rays.

    abstract::Chromosome painting by fluorescence in situ hybridization (FISH) with a whole chromosome-specific DNA probe was used to detect chromosomal aberrations in lymphocytes from cancer patients given partial-body fractionated X-ray therapy. Six male patients with cancer of the stomach, prostate, lung, or hepatocellular carci...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.37.257

    authors: Matsuoka A,Yamada K,Hayashi M,Sofuni T

    更新日期:1996-12-01 00:00:00

  • Development of a hybrid magnetic resonance/computed tomography-compatible phantom for magnetic resonance guided radiotherapy.

    abstract::The purpose of the present study was to develop a hybrid magnetic resonance/computed tomography (MR/CT)-compatible phantom and tissue-equivalent materials for each MR and CT image. Therefore, the essential requirements necessary for the development of a hybrid MR/CT-compatible phantom were determined and the developme...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz094

    authors: Kim MJ,Lee SR,Song KH,Baek HM,Choe BY,Suh TS

    更新日期:2020-03-23 00:00:00

  • Retention, excretion and translocation of 239Pu in rats following inhalation of 239PuO2 calcined at 1150 and 400 degrees C.

    abstract::Wistar rats inhaled 239PuO2 particles prepared by the calcination of 239Pu hydroxide at 1150 and 400 degrees C. Lung retention, fecal and urinary excretion, and translocation of 239Pu were compared between the two calcination temperatures. The clearance of 239Pu from the lungs was significantly faster in the rats expo...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.197

    authors: Sato H,Yamada Y,Ishigure N,Nakano T,Enomoto H,Takahashi S,Kubota Y,Inaba J

    更新日期:1999-06-01 00:00:00

  • Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation.

    abstract::The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt118

    authors: Diffenderfer ES,Dolney D,Schaettler M,Sanzari JK,McDonough J,Cengel KA

    更新日期:2014-03-01 00:00:00

  • Electron probe X-ray microanalysis of boar and inobuta testes after the Fukushima accident.

    abstract::We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv070

    authors: Yamashiro H,Abe Y,Hayashi G,Urushihara Y,Kuwahara Y,Suzuki M,Kobayashi J,Kino Y,Fukuda T,Tong B,Takino S,Sugano Y,Sugimura S,Yamada T,Isogai E,Fukumoto M

    更新日期:2015-12-01 00:00:00

  • Relationship between sentinel lymph nodes and postoperative tangential fields in early breast cancer, evaluated using SPECT/CT.

    abstract::Single-photon emission computed tomography/computed tomography (SPECT/CT) demonstrates the precise location of the sentinel lymph nodes (SLNs) in patients with breast cancer. We evaluated the relationship between SLNs and postoperative tangential fields by using SPECT/CT images. Subjects included 72 patients with earl...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv035

    authors: Wadasaki K,Nishibuchi I

    更新日期:2015-09-01 00:00:00

  • Recombinant human epidermal growth factor (rhEGF) protects radiation-induced intestine injury in murine system.

    abstract::This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.09145

    authors: Oh H,Seong J,Kim W,Park S,Koom WS,Cho NH,Song M

    更新日期:2010-01-01 00:00:00

  • Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies.

    abstract::We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs021

    authors: Hojo H,Zenda S,Akimoto T,Kohno R,Kawashima M,Arahira S,Nishio T,Tahara M,Hayashi R,Sasai K

    更新日期:2012-09-01 00:00:00

  • DNA damage response induces structural alterations in histone H3-H4.

    abstract::Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw086

    authors: Izumi Y,Fujii K,Yamamoto S,Matsuo K,Namatame H,Taniguchi M,Yokoya A

    更新日期:2017-01-01 00:00:00

  • Biological and physical dosimeters for monitoring solar UV-B light.

    abstract::A biological dosimetry system for measuring solar UV-B light was established using bacteriophage T1 with E. coli Bs-1 as the host cell. Also a new physical UV-B dosimeter was developed which can specifically detect the UV spectral region related to inactivation of phage T1. Phage T1 is very stable in liquid suspension...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.31.189

    authors: Furusawa Y,Suzuki K,Sasaki M

    更新日期:1990-06-01 00:00:00

  • Dosimetric comparison between volumetric modulated arc therapy planning techniques for prostate cancer in the presence of intrafractional organ deformation.

    abstract::The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverag...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa123

    authors: Varnava M,Sumida I,Oda M,Kurosu K,Isohashi F,Seo Y,Otani K,Ogawa K

    更新日期:2020-12-21 00:00:00

  • Percutaneous fiducial marker placement prior to stereotactic body radiotherapy for malignant liver tumors: an initial experience.

    abstract::The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv099

    authors: Ohta K,Shimohira M,Murai T,Nishimura J,Iwata H,Ogino H,Hashizume T,Shibamoto Y

    更新日期:2016-03-01 00:00:00

  • Strategies for prediction and mitigation of radiation-induced liver toxicity.

    abstract::Although well described in the 1960s, liver toxicity secondary to radiation therapy, commonly known as radiation-induced liver disease (RILD), remains a major challenge. RILD encompasses two distinct clinical entities, a 'classic' form, composed of anicteric hepatomegaly, ascites and elevated alkaline phosphatase; and...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx104

    authors: Toesca DAS,Ibragimov B,Koong AJ,Xing L,Koong AC,Chang DT

    更新日期:2018-03-01 00:00:00

  • Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model.

    abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt108

    authors: Sanzari JK,Wan SX,Diffenderfer ES,Cengel KA,Kennedy AR

    更新日期:2014-03-01 00:00:00

  • Time course of reoxygenation in experimental murine tumors after carbon-beam and X-ray irradiation.

    abstract::We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irrad...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.42.131

    authors: Oya N,Sasai K,Shibata T,Takagi T,Shibuya K,Koike S,Nojima K,Furusawa Y,Ando K,Hiraoka M

    更新日期:2001-06-01 00:00:00

  • Estimation of yields of OH radicals in water irradiated by ionizing radiation.

    abstract::The yield of OH radical induced by ionizing radiation was estimated by an empirical model; a prescribed diffusion model for a spur of single size applying to neutral water. Two representative spur distances were introduced, one for an incident primary charged particle and one for a representative secondary electron, t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.46.333

    authors: Yamaguchi H,Uchihori Y,Yasuda N,Takada M,Kitamura H

    更新日期:2005-09-01 00:00:00

  • Implementation of Gy-Eq for deterministic effects limitation in shield design.

    abstract::The NCRP has recently defined RBE values and a new quantity (Gy-Eq) for use in estimation of deterministic effects in space shielding and operations. The NCRP's RBE for neutrons is left ambiguous and not fully defined. In the present report we will suggest a complete definition of neutron RBE consistent with the NCRP ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s103

    authors: Wilson JW,Kim MH,De Angelis G,Cucinotta FA,Yoshizawa N,Badavi FF

    更新日期:2002-12-01 00:00:00

  • The LD50 associated with exposure to the atomic bombing of Hiroshima and Nagasaki.

    abstract::Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was igno...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_154

    authors: Fujita S,Kato H,Schull WJ

    更新日期:1991-03-01 00:00:00

  • Blood flow change quantification in cervical cancer before and during radiation therapy using perfusion CT.

    abstract::The purpose of this study was to quantify the changes of tumor blood flow (BF) in cervical cancer after radiation therapy by using perfusion computed tomography (CT), and to examine the difference between maximum slope (MS) and single-input one-compartment model (SOCM) methods. Fourteen consecutive patients who receiv...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.11079

    authors: Shibuya K,Tsushima Y,Horisoko E,Noda SE,Taketomi-Takahashi A,Ohno T,Amanuma M,Endo K,Nakano T

    更新日期:2011-01-01 00:00:00

  • Biological effects of field emission-type X-rays generated by nanotechnology.

    abstract::Thermionic emission (TE)-type X-ray generators have been exclusively used in medicine, but there are many difficulties in making these X-ray sources compact. A field emission (FE)-type X-ray generator using carbon nanotubes is a newly-developed compact system that can be as small as several cm in length. Considering t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.06071

    authors: Nakazato T,Nakanishi M,Kita S,Okuyama F,Shibamoto Y,Otsuka T

    更新日期:2007-03-01 00:00:00

  • Changes in normal and abnormal colony formation of thyroid cells in vivo, when transplanted at 1 day or 6 weeks after X-irradiation in situ.

    abstract::Thyroid cells were given 5.5 Gy X-rays in situ and transplanted after 1 day or after 6 weeks to form colonies in fat pads. The colony-forming efficiency unexpectedly decreased by a factor of about 2 with this increase in delay time before transplantation. In addition, there was a concomitant marked increase above the ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.35.116

    authors: Watanabe H,Hendry JH

    更新日期:1994-06-01 00:00:00

  • Whole-pelvic radiotherapy with spot-scanning proton beams for uterine cervical cancer: a planning study.

    abstract::The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw052

    authors: Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

    更新日期:2016-09-01 00:00:00

  • Tritium precipitation in European cities and in Osaka, Japan owing to the Chernobyl nuclear accident.

    abstract::Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.267

    authors: Koga T,Morishima H,Niwa T,Kawai H

    更新日期:1991-09-01 00:00:00

  • 4D digitally reconstructed radiography for verifying a lung tumor position during volumetric modulated arc therapy.

    abstract::We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs013

    authors: Nakagawa K,Kida S,Haga A,Masutani Y,Yamashita H,Onoe T,Imae T,Tanaka K,Ohtomo K,Yoda K

    更新日期:2012-07-01 00:00:00

  • Equivalency of the quality of sublethal lesions after photons and high-linear energy transfer ion beams.

    abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx030

    authors: Furusawa Y,Nakano-Aoki M,Matsumoto Y,Hirayama R,Kobayashi A,Konishi T

    更新日期:2017-11-01 00:00:00

  • Subjective voice quality, communicative ability and swallowing after definitive radio(chemo)therapy, laryngectomy plus radio(chemo)therapy, or organ conservation surgery plus radio(chemo)therapy for laryngeal and hypopharyngeal cancer.

    abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru093

    authors: Szuecs M,Kuhnt T,Punke C,Witt G,Klautke G,Kramp B,Hildebrandt G

    更新日期:2015-01-01 00:00:00

  • Plutonium behavior after pulmonary administration according to solubility properties, and consequences on alveolar macrophage activation.

    abstract::The physico-chemical form in which plutonium enters the body influences the lung distribution and the transfer rate from lungs to blood. In the present study, we evaluated the early lung damage and macrophage activation after pulmonary contamination of plutonium of various preparation modes which produce different sol...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.11112

    authors: Van der Meeren A,Gremy O,Renault D,Miroux A,Bruel S,Griffiths N,Tourdes F

    更新日期:2012-01-01 00:00:00