Abstract:
:Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was ignored. The recent reassessment of the atomic bomb radiation dosimetry has provided an opportunity for the estimation of the bone marrow LD50. There is a surprising concordance in the various estimates that have been made given the different groups of survivors involved and the methods used to estimate the LD50/60.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Fujita S,Kato H,Schull WJdoi
10.1269/jrr.32.supplement_154subject
Has Abstractpub_date
1991-03-01 00:00:00pages
154-61eissn
0449-3060issn
1349-9157journal_volume
32 Supplpub_type
杂志文章,评审abstract::This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.47.135
更新日期:2006-06-01 00:00:00
abstract::In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw015
更新日期:2016-08-01 00:00:00
abstract::The radiation killing of tumor cells by ionizing radiation is best described by the linear-quadratic (LQ) model. Research into the underlying mechanisms of α- and β-inactivation has suggested that different molecular targets (DNA in different forms) and different microdosimetric energy deposits (spurs versus electron ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrt111
更新日期:2014-01-01 00:00:00
abstract::The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz073
更新日期:2020-01-23 00:00:00
abstract::To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1269/jrr.45.269
更新日期:2004-06-01 00:00:00
abstract::Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coi...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09012s
更新日期:2009-03-01 00:00:00
abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv047
更新日期:2015-11-01 00:00:00
abstract::We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv070
更新日期:2015-12-01 00:00:00
abstract::Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clini...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry033
更新日期:2018-05-01 00:00:00
abstract::Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa044
更新日期:2020-07-06 00:00:00
abstract::Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and are indispensable for antibacterial and antiviral immunity. Our previous report showed that ionizing radiation increases the cell surface expressions of TLR2 and TLR4 and enhances their responses to a...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx011
更新日期:2017-09-01 00:00:00
abstract::Preliminary results of the Polish epidemiology study on eye lens opacities among interventional cardiologists (ICs), based on the methodology proposed by ELDO (epidemiological studies of radio-induced cataracts in interventional cardiologists and radiologists: methodology implementation), are presented. The aim of the...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw019
更新日期:2016-07-01 00:00:00
abstract::Radiotherapy-induced toxicity is a major dose-limiting factor in anti-cancer treatment. Ionizing radiation leads to the formation of reactive oxygen and nitrogen species (ROS/RNS) that are associated with radiation-induced cell death. Investigations of biological effects of fullerenol have provided evidence for its RO...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.07092
更新日期:2008-05-01 00:00:00
abstract::This retrospective analysis focusses on the impact of therapy on perceived long-term post-cancer treatment function. A validated questionnaire including items and components for the assessment of communicative ability, quality of voice and swallowing was sent to 129 patients. All patients were treated between 1998 and...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru093
更新日期:2015-01-01 00:00:00
abstract::Patient A who was exposed to a critical dose of radiation developed skin lesions throughout the body surface, gastrointestinal disorder with massive diarrhea and prominent bleeding, which caused severe loss in body fluids. Gastrointestinal bleeding due to the deteriorated intestinal mucosa was considered to be one of ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.s167
更新日期:2001-09-01 00:00:00
abstract::Several models for the action of mixed irradiation with two types of radiation have been proposed in the last two decades, although the superiority or inferiority of these models is not completely elucidated. However, mixed irradiation is sometimes composed of more than two types of radiation, and for this type of mix...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.39.215
更新日期:1998-09-01 00:00:00
abstract::Six Japanese patients in Hokkaido area were diagnosed as xeroderma pigmentosum (XP) at two University Hospital; one patient, a 29 years old female (XP2AS) at Asahikawa Medical College, and five patients, namely, a 53 years old male (XP1SA), a 45 years old female (XP2SA), a 46 years old female (XP3SA), a 47 years old m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.168
更新日期:1994-09-01 00:00:00
abstract::The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome co...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1269/jrr.45.195
更新日期:2004-06-01 00:00:00
abstract::There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-D...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.361
更新日期:2002-12-01 00:00:00
abstract::The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using t...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa120
更新日期:2021-01-01 00:00:00
abstract::The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw024
更新日期:2016-07-01 00:00:00
abstract::Previous studies have demonstrated that X-ray irradiation affects angiogenesis in tumors. Here, we studied the effects of gamma-ray irradiation on boron-10 compound accumulation in a murine tumor model. The mouse squamous cell carcinoma was irradiated with gamma-ray before BSH ((10)B-enriched borocaptate sodium) admin...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.09071
更新日期:2009-11-01 00:00:00
abstract::The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.33.301
更新日期:1992-12-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::We investigated the efficacy and safety of albumin-bound paclitaxel (nab-PTX) and carboplatin (CBDCA) with concurrent radiotherapy for unresectable locally advanced non-small-cell lung cancer (NSCLC). Patients with Stage III NSCLC and an Eastern Cooperative Oncology Group performance status of 0 or 1 were eligible. Co...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv062
更新日期:2016-01-01 00:00:00
abstract::Male C3H/HeN mice were exposed to 252Cf radiation and mated with unirradiated C57BL/6N females. F1 mice were analyzed for germline mutation at the paternally derived C3H/HeN allele of a hypervariable minisatellite locus, Ms6hm. This locus exhibited a high frequency of length change mutation spontaneously, and the muta...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.37.217
更新日期:1996-09-01 00:00:00
abstract::When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s209
更新日期:2002-12-01 00:00:00
abstract::In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on ce...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.46.401
更新日期:2005-12-01 00:00:00
abstract::The pulse radiolysis technique has been employed to determine the initiation and propagation rates of different transient species involved in the polymerization of N-isopropylacrylamide (NIPA) in aqueous solutions. Polymerization by anionic mechanism has been observed to be faster than by the free-radical mechanism. T...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.335
更新日期:2003-12-01 00:00:00
abstract::Exposure to ionizing radiation leads to severe damages in radiosensitive organs and induces acute radiation syndrome, including effects on the hematopoietic system and gastrointestinal system. In this study, the radioprotective ability of KMRC011, a novel toll-like receptor 5 (TLR5) agonist, was investigated in C57BL6...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz024
更新日期:2019-07-01 00:00:00