Retention, excretion and translocation of 239Pu in rats following inhalation of 239PuO2 calcined at 1150 and 400 degrees C.

abstract：:The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

journal_title：Journal of radiation research

authors： Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

更新日期：2015-11-01 00:00:00

abstract：:When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

journal_title：Journal of radiation research

authors： Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

更新日期：2002-12-01 00:00:00

abstract：:To clarify the nature of the genes that contribute to the radiosensitivity of human hematopoietic stem/progenitor cells (HSPCs), we analyzed the gene expression profiles detected in HSPCs irradiated with 2 Gy X-rays after culture with or without an optimal combination of hematopoietic cytokines. Highly purified CD34(+...

journal_title：Journal of radiation research

authors： Tsujiguchi T,Hirouchi T,Monzen S,Tabuchi Y,Takasaki I,Kondo T,Kashiwakura I

更新日期：2016-01-01 00:00:00

abstract：:A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...

journal_title：Journal of radiation research

authors： Moreno JO,Pullia MG,Priano C,Lante V,Necchi MM,Savazzi S

更新日期：2013-07-01 00:00:00

abstract：:Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...

journal_title：Journal of radiation research

authors： Tokuyama Y,Furusawa Y,Ide H,Yasui A,Terato H

更新日期：2015-05-01 00:00:00

abstract：:The prognosis and treatment of thyroid cancer depends on the type and stage of the disease. Radiosensitivity differs among cancer cells owing to their varying capacity for repair after irradiation. Radioactive iodine can be used to destroy thyroid cancer cells. However, patient prognosis and improvement after irradiat...

journal_title：Journal of radiation research

authors： Ihara M,Ashizawa K,Shichijo K,Kudo T

更新日期：2019-03-01 00:00:00

abstract：:miR-34a is transcriptionally induced by the tumor suppressor gene p53, which is often downregulated in non-small cell lung cancer (NSCLC). To address whether the downstream signal of miR-34a is sufficient to induce apoptosis and to alter cellular radiosensitivity, a chemical synthetic miR-34a mimic was delivered into ...

journal_title：Journal of radiation research

authors： Duan W,Xu Y,Dong Y,Cao L,Tong J,Zhou X

更新日期：2013-07-01 00:00:00

abstract：:The purpose of this study was to assess the toxicity and efficacy of multimodal approaches, including three-dimensional conformal re-irradiation, for patients with recurrent or persistent esophageal cancer after radiotherapy. Thirty-one patients with esophageal cancer treated with three-dimensional conformal re-irradi...

journal_title：Journal of radiation research

authors： Yamaguchi S,Ohguri T,Imada H,Yahara K,Moon SD,Higure A,Yamaguchi K,Yoshikawa I,Harada M,Korogi Y

更新日期：2011-01-01 00:00:00

abstract：:We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...

journal_title：Journal of radiation research

authors： Ryo H,Nakajima H,Nomura T

更新日期：2006-01-01 00:00:00

abstract：:Immediately after X-irradiation, monocytic cells can express the gene for interleukin (IL)-1beta, which enhances inflammation and contributes to radioprotection in mice. In order to analyze the mechanism(s) for the immediate-early induction of IL-1beta after X-irradiation at 20 Gy in cultured murine macrophages, we ex...

journal_title：Journal of radiation research

authors： Ishihara H,Tanaka I,Wan H,Cheeramakara C

更新日期：2003-06-01 00:00:00

abstract：:The purpose of the study was to quantify local setup errors and evaluate the planning target volume (PTV) margins for sub-regions in cone-beam computed tomography (CBCT)-guided post-mastectomy radiation therapy (PMRT). The local setup errors of 20 patients undergoing CBCT-guided PMRT were analysed retrospectively. Ima...

journal_title：Journal of radiation research

authors： Zhou J,Li S,Ye C,Shen K,Li A,Chen G,Li X,Bai S,Wang W,Zhong R

更新日期：2020-05-22 00:00:00

abstract：:Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...

journal_title：Journal of radiation research

authors： Hata K,Urushibara A,Yamashita S,Lin M,Muroya Y,Shikazono N,Yokoya A,Fu H,Katsumura Y

更新日期：2015-01-01 00:00:00

abstract：:Neutron dose is transferred to biological materials through the recoil protons produced by elastic scattering. When a low-velocity proton collides with the atoms or molecules of a target, it changes to a hydrogen atom by electron capture; this hydrogen atom then changes to a proton by losing the electron. Because the ...

journal_title：Journal of radiation research

authors： Endo S

更新日期：2004-09-01 00:00:00

abstract：:Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was igno...

journal_title：Journal of radiation research

authors： Fujita S,Kato H,Schull WJ

更新日期：1991-03-01 00:00:00

abstract：:Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...

journal_title：Journal of radiation research

authors： Oike T,Ogiwara H,Amornwichet N,Nakano T,Kohno T

更新日期：2014-07-01 00:00:00

abstract：:Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to 239PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeare...

journal_title：Journal of radiation research

authors： Oghiso Y,Yamada Y

更新日期：2002-09-01 00:00:00

abstract：:The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...

journal_title：Journal of radiation research

authors： Ohkubo Y,Ohno T,Noda SE,Kubo N,Nakagawa A,Kawahara M,Abe T,Kiyohara H,Wakatsuki M,Nakano T

更新日期：2013-11-01 00:00:00

abstract：:Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E ...

journal_title：Journal of radiation research

authors： Shimada M,Komatsu K

更新日期：2009-07-01 00:00:00

abstract：:Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the...

journal_title：Journal of radiation research

authors： Nikezic D,Yu KN

更新日期：2017-03-01 00:00:00

abstract：:The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...

journal_title：Journal of radiation research

authors： Sanzari JK,Wan SX,Diffenderfer ES,Cengel KA,Kennedy AR

更新日期：2014-03-01 00:00:00

abstract：:The direct biological effects of radiation, particularly accelerated heavy particle ions, on neurons are not fully known. Hence, the direct effect of carbon-ion beams on immature neurons was investigated by comparing to the effect of X-rays in vitro using primary hippocampal neurons. Primary neurons were prepared from...

journal_title：Journal of radiation research

authors： Kaminuma T,Suzuki Y,Shirai K,Mizui T,Noda SE,Yoshida Y,Funayama T,Takahashi T,Kobayashi Y,Shirao T,Nakano T

更新日期：2010-01-01 00:00:00

abstract：:This study determined whether dynamic F-18 FDG PET imaging could differentiate benign from malignant solitary pulmonary nodules (SPNs). Histopathologically confirmed SPNs (10-35 mm), 24 malignant and 10 benign, from 34 patients were studied through both dynamic and static F-18 FDG PET imaging of all patients. Volumes ...

journal_title：Journal of radiation research

authors： Huang YE,Lu HI,Liu FY,Huang YJ,Lin MC,Chen CF,Wang PW

更新日期：2012-01-01 00:00:00

abstract：:The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...

journal_title：Journal of radiation research

authors： Uehara S,Nikjoo H

更新日期：2006-03-01 00:00:00

abstract：:To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subseque...

journal_title：Journal of radiation research

authors： Otomo T,Hishii M,Arai H,Sato K,Sasai K

更新日期：2004-03-01 00:00:00

abstract：:In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...

journal_title：Journal of radiation research

authors： Kim W,Seong J,Oh HJ,Koom WS,Choi KJ,Yun CO

更新日期：2011-01-01 00:00:00

abstract：:This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...

journal_title：Journal of radiation research

authors： Chu KH,Lin YT,Hsu CC,Chen CY,Pan LK

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this study was to describe the results of definitive radiotherapy (RT) with concurrent chemotherapy for maxillary sinus carcinomas (MSCs) with neck lymph node metastasis to clarify its limitation. Local control (LC), progression-free survival (PFS) and overall survival (OS) rates were calculated using t...

journal_title：Journal of radiation research

authors： Abe T,Saito S,Iino M,Aoshika T,Ryuno Y,Ohta T,Igari M,Hirai R,Kumazaki Y,Ebihara Y,Nakahira M,Sugasawa M,Noda SE,Kato S

更新日期：2021-01-01 00:00:00

abstract：:This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

journal_title：Journal of radiation research

authors： Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

更新日期：2019-03-01 00:00:00

abstract：:We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acq...

journal_title：Journal of radiation research

authors： Nakagawa K,Kida S,Haga A,Masutani Y,Yamashita H,Onoe T,Imae T,Tanaka K,Ohtomo K,Yoda K

更新日期：2012-07-01 00:00:00

abstract：:Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness of proton beam therapy (PBT) using a patch-field technique for large HCC. Data from nine patients (aged 52-79 years) with large HCC tr...

journal_title：Journal of radiation research

authors： Nakamura M,Fukumitsu N,Kamizawa S,Numajiri H,Nemoto Murofushi K,Ohnishi K,Aihara T,Ishikawa H,Okumura T,Tsuboi K,Sakurai H

更新日期：2018-09-01 00:00:00