Abstract:
:We have proposed four dimensional (4D) digitally reconstructed radiography (DRR) for verifying a lung tumor position during volumetric modulated arc therapy (VMAT). An internal target volume (ITV) was defined based on two clinical target volumes (CTVs) delineated on maximum exhalation and maximum inhalation images acquired by 4D planning computed tomography (CT). A planning target volume (PTV) was defined by adding a margin of 5 mm to the ITV on the maximum exhalation 3D CT images. A single-arc VMAT plan was created on the same CT data using Pinnacle SmartArc with a maximum multi-leaf collimator leaf speed of 1 mm/degree, thereby resulting in quasi-conformal field shapes while optimizing each beam intensity for each gantry angle. During VMAT delivery, cone-beam CT (CBCT) projection data were acquired by an on-board kilovoltage X-ray unit and a flat panel 2D detector. Four CBCT image sets with different respiratory phases were reconstructed using in-house software, where respiratory phases were extracted from the projection data. Subsequently a CTV was delineated on each of the 4D CBCT images by an oncologist. Using the resulting 4D CBCT data including the CTV contours, 4D DRRs during the VMAT delivery were calculated as a function of gantry angle. It was confirmed that the contoured CTV was within the radiation field during the four-fraction lung VMAT delivery. The proposed 4D DRR may facilitate the verification of the position of a respiratory moving lung tumor during VMAT delivery on each treatment day.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Nakagawa K,Kida S,Haga A,Masutani Y,Yamashita H,Onoe T,Imae T,Tanaka K,Ohtomo K,Yoda Kdoi
10.1093/jrr/rrs013subject
Has Abstractpub_date
2012-07-01 00:00:00pages
628-32issue
4eissn
0449-3060issn
1349-9157pii
rrs013journal_volume
53pub_type
杂志文章abstract::The purpose of this review was to evaluate the impact of epidermal growth factor receptor (EGFR) mutation status on disease recurrence in patients treated with chemoradiotherapy (CRT) for locally advanced non-small cell lung cancer (NSCLC). A literature search was conducted and a total of three studies were analyzed. ...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw075
更新日期:2016-09-01 00:00:00
abstract::This study evaluated cytogenetic damage by measuring the frequency of micronucleated cells (MNC) in peripheral blood and buccal mucosa of head-and-neck cancer patients undergoing radiotherapy. MNC frequencies were assessed in 31 patients before, during, and after radiotherapy, and in 17 healthy controls matched for ge...
journal_title:Journal of radiation research
pub_type: 临床试验,杂志文章
doi:10.1269/jrr.46.135
更新日期:2005-06-01 00:00:00
abstract::The purpose of this multi-institutional Phase II trial study was to prospectively investigate the efficacy of the herbal medicine TJ-14 for acute radiation-induced enteritis (ARE). TJ-14 was administered orally as a first-line treatment for ARE. The primary end point was efficacy at 1 week. The secondary end points we...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrz025
更新日期:2020-01-23 00:00:00
abstract::To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subseque...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.45.53
更新日期:2004-03-01 00:00:00
abstract::The fertility span between the first and the last estrus was compared among female Chinese hamsters exposed to 1 Gy X-rays on neonatal day 0, 2, 4, 6, 8, 10 and 14. The fertility span changed dramatically according to the age at the time of irradiation. The females irradiated on day 4, 6 and 8 showed a definite delay ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.30.185
更新日期:1989-06-01 00:00:00
abstract::This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa071
更新日期:2020-11-16 00:00:00
abstract::XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv086
更新日期:2016-03-01 00:00:00
abstract::Clustered DNA damage is a specific type of DNA damage induced by ionizing radiation. Any type of ionizing radiation traverses the target DNA molecule as a beam, inducing damage along its track. Our previous study showed that clustered DNA damage yields decreased with increased linear energy transfer (LET), leading us ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru122
更新日期:2015-05-01 00:00:00
abstract::To gain an insight into the relationship between UVB-carcinogenesis and natural killer activity, we examined ultraviolet light-induced carcinogenesis in mice with high natural killer, activity (KSN) and mice with natural killer deficiency (KSN-bg). We exposed mice six times a week to three levels of daily ultraviolet ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.39.119
更新日期:1998-06-01 00:00:00
abstract::Development of a curative local treatment for large hepatocellular carcinoma (HCC) is an important issue. Here, we investigated the dose homogeneity, safety and antitumor effectiveness of proton beam therapy (PBT) using a patch-field technique for large HCC. Data from nine patients (aged 52-79 years) with large HCC tr...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry056
更新日期:2018-09-01 00:00:00
abstract::miR-34a is transcriptionally induced by the tumor suppressor gene p53, which is often downregulated in non-small cell lung cancer (NSCLC). To address whether the downstream signal of miR-34a is sufficient to induce apoptosis and to alter cellular radiosensitivity, a chemical synthetic miR-34a mimic was delivered into ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs136
更新日期:2013-07-01 00:00:00
abstract::Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry085
更新日期:2019-01-01 00:00:00
abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_310
更新日期:1991-03-01 00:00:00
abstract::While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.38.179
更新日期:1997-09-01 00:00:00
abstract::In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.0625
更新日期:2007-01-01 00:00:00
abstract::The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of w...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.32.supplement_231
更新日期:1991-03-01 00:00:00
abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt108
更新日期:2014-03-01 00:00:00
abstract::The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt073
更新日期:2013-11-01 00:00:00
abstract::A photoluminescence glass dosimeter, GD-301, was applied to the measurement of low absorbed doses in mice exposed to low-dose rate 137Cs gamma-rays. The dosimeter system consists of small rod-shaped glass chip detectors capable of embedded in the body of a mouse and an automatic readout device equipped with a standard...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.129
更新日期:2000-06-01 00:00:00
abstract::As a part of technical improvements of chromosome aberration analysis on human peripheral lymphocytes for biological radiation dosimetry, we examined the optimal conditions for the use of colcemid in chromosome preparation in order to obtain enough number of cells at metaphase in the first cell division. When treated ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.41
更新日期:1994-03-01 00:00:00
abstract::Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clini...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rry033
更新日期:2018-05-01 00:00:00
abstract::Disufiram (a drug used for the treatment of alcoholism) protected microsomal membranes and plasmid DNA against damages induced by gamma-radiation. The peroxidation of membrane lipids increased linearly with the radiation dose up to 600 Gy, and the presence of disulfiram inhibited membrane lipid peroxidation as assayed...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.255
更新日期:2003-09-01 00:00:00
abstract::In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1093/jrr/rrw015
更新日期:2016-08-01 00:00:00
abstract::This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs050
更新日期:2012-11-01 00:00:00
abstract::The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx030
更新日期:2017-11-01 00:00:00
abstract::Patient A who was exposed to a critical dose of radiation developed skin lesions throughout the body surface, gastrointestinal disorder with massive diarrhea and prominent bleeding, which caused severe loss in body fluids. Gastrointestinal bleeding due to the deteriorated intestinal mucosa was considered to be one of ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.42.s167
更新日期:2001-09-01 00:00:00
abstract::Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.256
更新日期:1990-09-01 00:00:00
abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.supplement_40
更新日期:1991-03-01 00:00:00
abstract::The aim of this study was to carry out geometric and dosimetric evaluation of the usefulness of a deformable image registration algorithm utilized for adaptive head-and-neck intensity-modulated radiotherapy. Data consisted of seven patients, each with a planning CT (pCT), a rescanning CT (ReCT) and a cone beam CT (CBC...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru044
更新日期:2014-09-01 00:00:00
abstract::The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw052
更新日期:2016-09-01 00:00:00