Clinical outcomes for 61 cases of hypopharyngeal cancer with synchronous esophageal cancer.

Abstract:

:The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/chemoradiotherapy (28 cases), surgery (9 cases), palliative radiotherapy and/or chemotherapy (17 cases), or supportive care (7 cases). The median radiotherapy doses for EC and HPC in the radiotherapy/chemoradiotherapy group were 64.5 Gy (range, 0-70) and 70 Gy (range, 60-75.2), respectively. Seven patients in the surgery group received pharyngoesophagectomy with gastric pull-up reconstruction, and two received esophagectomy followed by radiotherapy at the hypopharynx. Cox proportional hazard analysis revealed that the outcome of active treatments, including surgery and radiotherapy/chemoradiotherapy, was better than that of conservative care. In survival analysis, patients in the surgery group tended to have a better 3-year overall survival rate than those in the radiotherapy/chemoradiotherapy group (55.6% vs 30.9%); however, this difference was not statistically different (P = 0.493). The two groups had similar 3-year progression-free survival rates (30.6% and 33.3%, P = 0.420). The current study suggested that radiotherapy/chemoradiotherapy should be considered as an important treatment modality in addition to surgery for synchronous HPC and EC.

journal_name

J Radiat Res

authors

Yang S,Yang S,Liao W,Huang R,Li B,Lu S,Li C,Wang Z,Li C,Pei J,Wen H,Zhang S

doi

10.1093/jrr/rrz042

subject

Has Abstract

pub_date

2019-10-23 00:00:00

pages

658-665

issue

5

eissn

0449-3060

issn

1349-9157

pii

5524788

journal_volume

60

pub_type

杂志文章
  • An approach to estimate radioadaptation from DSB repair efficiency.

    abstract::In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.09050

    authors: Yatagai F,Sugasawa K,Enomoto S,Honma M

    更新日期:2009-09-01 00:00:00

  • General ion recombination effect in a liquid ionization chamber in high-dose-rate pulsed photon and electron beams.

    abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx088

    authors: Takei H,Isobe T,Kitamura N,Mori Y,Tomita T,Kobayashi D,Kamizawa S,Sato T,Sakurai H,Sakae T

    更新日期:2018-05-01 00:00:00

  • Assessing residual motion for gated proton-beam radiotherapy.

    abstract::Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to red...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.48.a55

    authors: Sharp GC,Lu HM,Trofimov A,Tang X,Jiang SB,Turcotte J,Gierga DP,Chen GT,Hong TS

    更新日期:2007-01-01 00:00:00

  • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Aging.

    abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_310

    authors: Sasaki H,Kodama K,Yamada M

    更新日期:1991-03-01 00:00:00

  • The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy.

    abstract::New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesor...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz092

    authors: Alickikus ZA,Kuru A,Aydin B,Akcay D,Gorken IB

    更新日期:2020-03-23 00:00:00

  • Differences in the dose-volume metrics with heterogeneity correction status and its influence on local control in stereotactic body radiation therapy for lung cancer.

    abstract::The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs084

    authors: Ueki N,Matsuo Y,Shibuya K,Nakamura M,Narabayashi M,Sakanaka K,Norihisa Y,Mizowaki T,Hiraoka M

    更新日期:2013-03-01 00:00:00

  • Immunohistochemical study on cellular origins of rat lung tumors induced by inhalation exposures to plutonium dioxide aerosols as compared to those by X-ray irradiation.

    abstract::Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to 239PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeare...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.301

    authors: Oghiso Y,Yamada Y

    更新日期:2002-09-01 00:00:00

  • Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice.

    abstract::The radioprotective effect of chitosan was studied in mice following whole-body X-ray irradiation. C3H/He mice were exposed to 7 Gy, and their survival rates were examined. The survival rates of chitosan-diet mice were about 20% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau a...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.44.53

    authors: Nishimura Y,Kim HS,Ikota N,Arima H,Bom HS,Kim YH,Watanabe Y,Yukawa M,Ozawa T

    更新日期:2003-03-01 00:00:00

  • Simulation of proton neutralization effect for neutron dosimetry.

    abstract::Neutron dose is transferred to biological materials through the recoil protons produced by elastic scattering. When a low-velocity proton collides with the atoms or molecules of a target, it changes to a hydrogen atom by electron capture; this hydrogen atom then changes to a proton by losing the electron. Because the ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.45.351

    authors: Endo S

    更新日期:2004-09-01 00:00:00

  • Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.

    abstract::Differentiation-induction therapy is an attractive approach in leukemia treatment. It has been suggested that the accumulation of intracellular reactive oxygen species (ROS) is involved in megakaryocytic differentiation induced by phorbol 12-myristate 13-acetate (PMA) in the K562 leukemia cell line. Therefore, a ROS-i...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs125

    authors: Hirose K,Monzen S,Sato H,Sato M,Aoki M,Hatayama Y,Kawaguchi H,Narita Y,Takai Y,Kashiwakura I

    更新日期:2013-05-01 00:00:00

  • Validating the efficacy of single-stage breast-conserving therapy using multicatheter partial-breast brachytherapy based on updated ASTRO guidelines.

    abstract::Based on the accumulating evidence for equivalent results of partial-breast irradiation (PBI) and whole-breast irradiation (WBI) in breast-conserving therapy (BCT), the American Society for Radiation Oncology (ASTRO) updated the consensus statement (CS) to expand the range of potential candidates for PBI outside clini...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry033

    authors: Sato K,Fuchikami H,Takeda N,Kato M,Shimo T,Okawa T

    更新日期:2018-05-01 00:00:00

  • Investigation of whether in-room CT-based adaptive intracavitary brachytherapy for uterine cervical cancer is robust against interfractional location variations of organs and/or applicators.

    abstract::This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw043

    authors: Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

    更新日期:2016-11-01 00:00:00

  • Tritium concentration in unpolished rice.

    abstract::Inoue and Iwakura recently reported that the specific activity ratio of organically-bound 3H to free water 3H in polished rice samples collected in Japan and China was lower than unity. Their paper was the first to report the systematic apparent elimination of 3H for incorporation to organically-bound form in samples ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.389

    authors: Hisamatsu S,Katsumata T,Takizawa Y

    更新日期:1991-12-01 00:00:00

  • Salvage radiotherapy after radical prostatectomy: outcomes and prognostic factors especially focusing on pathological findings.

    abstract::External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage R...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs034

    authors: Hayashi S,Hayashi K,Yoshimura R,Masuda H,Kihara K,Shibuya H

    更新日期:2012-09-01 00:00:00

  • Protective roles of bacterioruberin and intracellular KCl in the resistance of Halobacterium salinarium against DNA-damaging agents.

    abstract::Halobacterium salinarium, a member of the extremely halophilic archaebacteria, contains a C50-carotenoid namely bacterioruberin. We have previously reported the high resistance of this organism against the lethal actions of DNA-damaging agents including ionizing radiation and ultraviolet light (UV). In this study, we ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.39.251

    authors: Shahmohammadi HR,Asgarani E,Terato H,Saito T,Ohyama Y,Gekko K,Yamamoto O,Ide H

    更新日期:1998-12-01 00:00:00

  • Mutation induction and RBE of low energy neutrons in V79 cells.

    abstract::We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.s21

    authors: Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

    更新日期:1999-12-01 00:00:00

  • In cellulo phosphorylation of XRCC4 Ser320 by DNA-PK induced by DNA damage.

    abstract::XRCC4 is a protein associated with DNA Ligase IV, which is thought to join two DNA ends at the final step of DNA double-strand break repair through non-homologous end joining. In response to treatment with ionizing radiation or DNA damaging agents, XRCC4 undergoes DNA-PK-dependent phosphorylation. Furthermore, Ser260 ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv086

    authors: Sharma MK,Imamichi S,Fukuchi M,Samarth RM,Tomita M,Matsumoto Y

    更新日期:2016-03-01 00:00:00

  • Activities of the Japanese space weather forecast center at Communications Research Laboratory.

    abstract::The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s53

    authors: Watari S,Tomita F

    更新日期:2002-12-01 00:00:00

  • Evaluation of the intake of radon through skin from thermal water.

    abstract::The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw024

    authors: Sakoda A,Ishimori Y,Tschiersch J

    更新日期:2016-07-01 00:00:00

  •  Generation of low-flux X-ray micro-planar beams and their biological effect on a murine subcutaneous tumor model.

    abstract::We generated low-flux X-ray micro-planar beams (MPBs) using a laboratory-scale industrial X-ray generator (60 kV/20 mA) with custom-made collimators with three different peak/pitch widths (50/200 μm, 100/400 μm, 50/400 μm). To evaluate normal skin reactions, the thighs of C3H/HeN mice were exposed to 100 and 200 Gy MP...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv037

    authors: Hong Z,Zenkoh J,Le B,Gerelchuluun A,Suzuki K,Moritake T,Washio M,Urakawa J,Tsuboi K

    更新日期:2015-09-01 00:00:00

  • p53-dependent signal transduction induced by stress.

    abstract::While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.38.179

    authors: Wang X,Ohnishi T

    更新日期:1997-09-01 00:00:00

  • Application of a newly developed photoluminescence glass dosimeter for measuring the absorbed dose in individual mice exposed to low-dose rate 137Cs gamma-rays.

    abstract::A photoluminescence glass dosimeter, GD-301, was applied to the measurement of low absorbed doses in mice exposed to low-dose rate 137Cs gamma-rays. The dosimeter system consists of small rod-shaped glass chip detectors capable of embedded in the body of a mouse and an automatic readout device equipped with a standard...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.41.129

    authors: Hoshi Y,Nomura T,Oda T,Iwasaki T,Fujita K,Ishikawa T,Kato A,Ikegami T,Sakai K,Tanooka H,Yamada T

    更新日期:2000-06-01 00:00:00

  • Chromatin-regulating proteins as targets for cancer therapy.

    abstract::Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1093/jrr/rrt227

    authors: Oike T,Ogiwara H,Amornwichet N,Nakano T,Kohno T

    更新日期:2014-07-01 00:00:00

  • Three-dimensional dose prediction and validation with the radiobiological gamma index based on a relative seriality model for head-and-neck IMRT.

    abstract::This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx017

    authors: Hamatani N,Sumida I,Takahashi Y,Oda M,Seo Y,Isohashi F,Tamari K,Ogawa K

    更新日期:2017-09-01 00:00:00

  • Characteristics of interventional cardiologists and their work practices for the study on radiation-induced lens opacities based on the methodology developed by ELDO-preliminary results.

    abstract::Preliminary results of the Polish epidemiology study on eye lens opacities among interventional cardiologists (ICs), based on the methodology proposed by ELDO (epidemiological studies of radio-induced cataracts in interventional cardiologists and radiologists: methodology implementation), are presented. The aim of the...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw019

    authors: Domienik J,Gryglak S,Jurewicz J

    更新日期:2016-07-01 00:00:00

  • Involvement of connexin43 hemichannel in ATP release after γ-irradiation.

    abstract::Ionizing radiation induces biological effects not only in irradiated cells but also in non-irradiated cells, which is called the bystander effect. Recently, in vivo and in vitro experiments have suggested that both gap junction hemichannel connexin43 (Cx43) and extracellular adenosine triphosphate (ATP) released from ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs014

    authors: Ohshima Y,Tsukimoto M,Harada H,Kojima S

    更新日期:2012-07-01 00:00:00

  • The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation.

    abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt061

    authors: Edin NJ,Sandvik JA,Vollan HS,Reger K,Görlach A,Pettersen EO

    更新日期:2013-11-01 00:00:00

  • Monte Carlo modeling in CT-based geometries: dosimetry for biological modeling experiments with particle beam radiation.

    abstract::The space radiation environment imposes increased dangers of exposure to ionizing radiation, particularly during a solar particle event (SPE). These events consist primarily of low energy protons that produce a highly inhomogeneous dose distribution. Due to this inherent dose heterogeneity, experiments designed to inv...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt118

    authors: Diffenderfer ES,Dolney D,Schaettler M,Sanzari JK,McDonough J,Cengel KA

    更新日期:2014-03-01 00:00:00

  • Evaluation of effective dose for a patient under Ga-67 nuclear examination using TLD, water phantom and a simplified model.

    abstract::This study evaluated the effective dose of Ga-67 for a patient undergoing Ga-67 citrate nuclear examination by applying thermoluminescent dosimeter (TLD) technique and an indigenous water phantom. The Ga-67 radionuclide remaining in the body inevitably generated a measurable internal dose even though gamma camera scan...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs050

    authors: Chu KH,Lin YT,Hsu CC,Chen CY,Pan LK

    更新日期:2012-11-01 00:00:00

  • Development of a biological dosimeter for translocation scoring based on two-color fluorescence in situ hybridization of chromosome subsets.

    abstract::Recently fluorescence in situ hybridization protocols have been developed which allow the painting of individual chromosomes using DNA-libraries from sorted human chromosomes. This approach has the particular advantage that radiation induced chromosome translocations can be easily detected, if chromosomes of distinctl...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.33.supplement_61

    authors: Popp S,Cremer T

    更新日期:1992-03-01 00:00:00