The importance of mesorectum motion in determining PTV margins in rectal cancer patients treated with neoadjuvant radiotherapy.

Abstract:

:New precision radiotherapy (RT) techniques reduce the uncertainties in localizing soft and moving tumors. However, there are still many uncontrollable internal organ movements. In our study, patients who underwent neoadjuvant chemoradiotherapy (NA-CRT) for rectal cancer were evaluated to determine inter-fraction mesorectum motion and dosimetric changes. Fourteen patients treated with NA-CRT for rectal cancer between 2014 and 2016 were included in the analysis. The mesorectum and clinical target volume (CTV) were delineated on planning computed tomography (CT) and cone-beam CT (CB-CT) scans. After planning with a volumetric modulated arc therapy (VMAT) plan, re-planning was performed on all CB-CTs. Finally, the volumetric and dosimetric changes of PTV and mesorectum were evaluated in all CB-CTs compared with the initial CT and VMAT plans. The geometrical center of mesorectum volume in CB-CTs had moved 1 (0.2-6.6), 1.6 (0.2-3.8) and 1.6 (0-4.9) mm in the x, y and z-axis respectively compared with the initial CT. The dosimetric parameters of PTV including D2, D95 and D98 on CB-CT showed a median 47.19 (46.70-47.80), 45.05 (44.18-45.68) and 44.69 (43.83-45.48) Gy and median 1% (1-2), 0% (0-2) and 1% (0-2) dosimetric change compared with the initial VMAT plan. In our study, we have shown that the mesorectum has moved up to 20 mm in the lateral and anterior-posterior direction and almost 10 mm in the superior/inferior direction during RT, causing a median of ~2% change in dosimetric parameters. Therefore, these movements must be considered in determining PTV margins to avoid dosimetric changes.

journal_name

J Radiat Res

authors

Alickikus ZA,Kuru A,Aydin B,Akcay D,Gorken IB

doi

10.1093/jrr/rrz092

subject

Has Abstract

pub_date

2020-03-23 00:00:00

pages

335-342

issue

2

eissn

0449-3060

issn

1349-9157

pii

5681346

journal_volume

61

pub_type

杂志文章
  • Reassessment of the cancer mortality risk among Hiroshima atomic-bomb survivors using a new dosimetry system, ABS2000D, compared with ABS93D.

    abstract::The aim of the present study was to examine the excess relative risk for leukemia mortality and all cancers, except leukemia, among Hiroshima atomic-bomb survivors by applying ABS93D and ABS2000D. Particular attention was given to any difference in the neutron-dose estimates between the two dosimetry systems. The stud...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.53

    authors: Katayama H,Matsuura M,Endo S,Hoshi M,Ohtaki M,Hayakawa N

    更新日期:2002-03-01 00:00:00

  • Effect of gamma-irradiation on the uptake and digestion of 125I-labeled bovine serum albumin by rat visceral yolk sac cultured in vitro.

    abstract::The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.34.171

    authors: Takahashi S,Koshimoto C,Kubota Y

    更新日期:1993-06-01 00:00:00

  • Microbeam studies of the bystander response.

    abstract::Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coi...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.09012s

    authors: Prise KM,Schettino G,Vojnovic B,Belyakov O,Shao C

    更新日期:2009-03-01 00:00:00

  • Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions.

    abstract::The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome co...

    journal_title:Journal of radiation research

    pub_type: 临床试验,杂志文章

    doi:10.1269/jrr.45.195

    authors: Lee R,Yamada S,Yamamoto N,Miyamoto T,Ando K,Durante M,Tsujii H

    更新日期:2004-06-01 00:00:00

  • Serum lactate dehydrogenase predicts survival in small-cell lung cancer patients with brain metastases that were treated with whole-brain radiotherapy.

    abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry107

    authors: Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

    更新日期:2019-03-01 00:00:00

  • Effects of neonatal ovarian X-irradiation in the Chinese hamster. I. Correlation between the age of irradiation and the fertility span.

    abstract::The fertility span between the first and the last estrus was compared among female Chinese hamsters exposed to 1 Gy X-rays on neonatal day 0, 2, 4, 6, 8, 10 and 14. The fertility span changed dramatically according to the age at the time of irradiation. The females irradiated on day 4, 6 and 8 showed a definite delay ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.30.185

    authors: Tateno H,Mikamo K

    更新日期:1989-06-01 00:00:00

  • Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA.

    abstract::Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was found to reduce the dGMP hydroxyl radical adducts through electron transfer reactions. The rate constants of the reactions were g...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru079

    authors: Hata K,Urushibara A,Yamashita S,Lin M,Muroya Y,Shikazono N,Yokoya A,Fu H,Katsumura Y

    更新日期:2015-01-01 00:00:00

  • Study of the magnets used for a mobile isocenter carbon ion gantry.

    abstract::A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt041

    authors: Moreno JO,Pullia MG,Priano C,Lante V,Necchi MM,Savazzi S

    更新日期:2013-07-01 00:00:00

  • Stereotactic body radiation therapy for head and neck tumor: disease control and morbidity outcomes.

    abstract::We evaluated the efficacy and safety of stereotactic body radiation therapy (SBRT) for patients with head and neck tumors. From April 2005 through April 2008, 34 patients with head and neck tumors were treated with CyberKnife SBRT. Twenty-one of them had prior radiotherapy. Treatment sites were orbit (n = 7), cervical...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10086

    authors: Kodani N,Yamazaki H,Tsubokura T,Shiomi H,Kobayashi K,Nishimura T,Aibe N,Ikeno H,Nishimura T

    更新日期:2011-01-01 00:00:00

  • A gradient of radioactive contamination in Dolon village near the SNTS and comparison of computed dose values with instrumental estimates for the 29 August, 1949 nuclear test.

    abstract::Spatial distributions of soil contamination by 137Cs (89 sampling points) and 239+240Pu (76 points) near and within Dolon village were analyzed. An essential exponential decrease of contamination was found in Dolon village: the distance of a half reduction in contamination is about 0.87-1.25 km (in a northwest-southea...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.47.a149

    authors: Stepanenko VF,Hoshi M,Dubasov YV,Sakaguchi A,Yamamoto M,Orlov MY,Bailiff IK,Ivannikov AI,Skvortsov VG,Iaskova EK,Kryukova IG,Zhumadilov KS,Endo S,Tanaka K,Apsalikov KN,Gusev BI

    更新日期:2006-02-01 00:00:00

  • Assessment of simulated high-dose partial-body irradiation by PCC-R assay.

    abstract::The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt032

    authors: Romero I,García O,Lamadrid AI,Gregoire E,González JE,Morales W,Martin C,Barquinero JF,Voisin P

    更新日期:2013-09-01 00:00:00

  • Overall image of nuclear tests and their human effects at Semipalatinsk: an attempt at analyses based on verbal data.

    abstract::The present paper is part of an attempt at finally reconstructing the realities of nuclear tests and their human effects near Semipalatinsk, Kazakhstan. As a first step, it tries to reconstruct the overall image of nuclear tests and their human effects. Our data are 199 written testimonies of those affected by radiati...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.47.a219

    authors: Matsuo M,Kawano N,Satoh K,Apsalikov KN,Moldagaliev T

    更新日期:2006-02-01 00:00:00

  • Preliminary study on radiosensitivity to carbon ions in human breast cancer.

    abstract::The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle dist...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa017

    authors: Zhang Q,Kong Y,Yang Z,Liu Y,Liu R,Geng Y,Luo H,Zhang H,Li H,Feng S,Wang X

    更新日期:2020-05-22 00:00:00

  • Impact of early radiological response evaluation on radiotherapeutic outcomes in the patients with nasal cavity and paranasal sinus malignancies.

    abstract::We analyzed the correlation between primary tumor response within 6 months after radiation therapy (RT) including proton beam therapy (PBT) and progression free survival rate (PFS) in patients with nasal cavity and paranasal sinus malignancies to clarify the impact of early radiological evaluation of treatment respons...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrs021

    authors: Hojo H,Zenda S,Akimoto T,Kohno R,Kawashima M,Arahira S,Nishio T,Tahara M,Hayashi R,Sasai K

    更新日期:2012-09-01 00:00:00

  • Radiation-induced motility alterations in medulloblastoma cells.

    abstract::Photon irradiation has been repeatedly suspected of increasing tumor cell motility and promoting locoregional recurrence of disease. This study was set up to analyse possible mechanisms underlying the potentially radiation-altered motility in medulloblastoma cells. Medulloblastoma cell lines D425 and Med8A were analyz...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rru120

    authors: Rieken S,Rieber J,Brons S,Habermehl D,Rief H,Orschiedt L,Lindel K,Weber KJ,Debus J,Combs SE

    更新日期:2015-05-01 00:00:00

  • The role of the sympathetic nervous system in radiation-induced apoptosis in jejunal crypt cells of spontaneously hypertensive rats.

    abstract::To evaluate the effect of the sympathetic nervous system on radiation-induced apoptosis in jejunal crypt cells, apoptosis levels were compared in spontaneously hypertensive rats (SHR), animals which are a genetic hyperfunction model of the sympathetic nervous system, and normotensive Wistar-Kyoto rats (WKY). SHR and W...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.41.55

    authors: Matsuu M,Shichijo K,Nakamura Y,Ikeda Y,Naito S,Ito M,Okaichi K,Sekine I

    更新日期:2000-03-01 00:00:00

  • Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model.

    abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt108

    authors: Sanzari JK,Wan SX,Diffenderfer ES,Cengel KA,Kennedy AR

    更新日期:2014-03-01 00:00:00

  • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Aging.

    abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_310

    authors: Sasaki H,Kodama K,Yamada M

    更新日期:1991-03-01 00:00:00

  • Radiation carcinogenesis in dogs irradiated during prenatal and postnatal development.

    abstract::To evaluate the lifetime hazards of ionizing radiation exposure, 1680 beagles received whole-body, 60-Cobalt gamma exposures or sham-exposures during development. Eight groups of 120 dogs each received mean doses of 16 or 83 cGy at 8 (preimplantation), 28 (embryonic), or 55 (late fetal) days postcoitus (dpc), or 2 (ne...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement2_86

    authors: Benjamin SA,Saunders WJ,Angleton GM,Lee AC

    更新日期:1991-12-01 00:00:00

  • Consecutive CT-guided core needle tissue biopsy of lung lesions in the same dog at different phases of radiation-induced lung injury.

    abstract::This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw053

    authors: Yin Z,Deng S,Liang Z,Wang Q

    更新日期:2016-09-01 00:00:00

  • Reassessment of gamma-ray doses in Hiroshima and Nagasaki.

    abstract::Reassessment of gamma-ray doses from the atomic bombs in Hiroshima and Nagasaki has been carried out with the thermoluminescent measurements of bricks and decorative tiles which were collected from the buildings that remain as they were at the time of the explosions. The thermoluminescent measurements were performed u...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.32.supplement_40

    authors: Maruyama T,Kumamoto Y,Noda Y

    更新日期:1991-03-01 00:00:00

  • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Cancer risk among in utero-exposed survivors.

    abstract::The Radiation Effects Research Foundation (RERF) continues to conduct a follow-up study initiated some years ago of cancer mortality and incidence among the survivors of the atomic bombing of Hiroshima and Nagasaki exposed in utero. Although only 18 incident cases of cancer were identified in the years 1950-1984 (of w...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_231

    authors: Yoshimoto Y,Kato H,Schull WJ

    更新日期:1991-03-01 00:00:00

  • Estimation of internal dose from tap water after the Fukushima Daiichi Nuclear Power Station accident using newly obtained data.

    abstract::Massive release of radioactive materials into the atmosphere occurred due to the Fukushima Daiichi Nuclear Power Station (FDNPS) accident in March 2011. The World Health Organization (WHO) and the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR) reported the results of dose estimation t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz089

    authors: Miyatake H,Kawai M,Yoshizawa N,Suzuki G

    更新日期:2020-03-23 00:00:00

  • Treatment outcomes of patients with FIGO Stage I/II uterine cervical cancer treated with definitive radiotherapy: a multi-institutional retrospective research study.

    abstract::The purpose of this study was to analyze the patterns of care and outcomes of patients with FIGO Stage I/II cervical cancer who underwent definitive radiotherapy (RT) at multiple Japanese institutions. The Japanese Radiation Oncology Study Group (JROSG) performed a questionnaire-based survey of their cervical cancer p...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,多中心研究

    doi:10.1093/jrr/rrv036

    authors: Ariga T,Toita T,Kato S,Kazumoto T,Kubozono M,Tokumaru S,Eto H,Nishimura T,Niibe Y,Nakata K,Kaneyasu Y,Nonoshita T,Uno T,Ohno T,Iwata H,Harima Y,Wada H,Yoshida K,Gomi H,Numasaki H,Teshima T,Yamada S,Nakano T

    更新日期:2015-09-01 00:00:00

  • Mutation induction and RBE of low energy neutrons in V79 cells.

    abstract::We have examined the neutron energy dependency of cell killing and mutation induction at the hprt locus in Chinese hamster V79 cells. Monoenergetic neutrons at 0.32, 0.57, and 1.2 MeV were generated at the Hiroshima University Radiobiological Research Accelerator (HIRRAC) Facility, and were used to irradiate cells. Th...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.40.s21

    authors: Kubota N,Okada S,Nagatomo S,Ozawa F,Inada T,Hill CK,Endo S,Komatsu K

    更新日期:1999-12-01 00:00:00

  • Rectal content and intrafractional prostate gland motion assessed by magnetic resonance imaging.

    abstract::We evaluated the interrelationship between rectal content and intrafraction motion of the prostate. Forty seven prostate cancer patients instructed to remove their rectal gas were imaged by planning CT and MRI before radiotherapy (RT) and during RT. The total scan time was comparable to our cone-beam CT scanning and t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10126

    authors: Ogino I,Kaneko T,Suzuki R,Matsui T,Takebayashi S,Inoue T,Morita S

    更新日期:2011-01-01 00:00:00

  • Implementation of Gy-Eq for deterministic effects limitation in shield design.

    abstract::The NCRP has recently defined RBE values and a new quantity (Gy-Eq) for use in estimation of deterministic effects in space shielding and operations. The NCRP's RBE for neutrons is left ambiguous and not fully defined. In the present report we will suggest a complete definition of neutron RBE consistent with the NCRP ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s103

    authors: Wilson JW,Kim MH,De Angelis G,Cucinotta FA,Yoshizawa N,Badavi FF

    更新日期:2002-12-01 00:00:00

  • DNA damage response induces structural alterations in histone H3-H4.

    abstract::Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw086

    authors: Izumi Y,Fujii K,Yamamoto S,Matsuo K,Namatame H,Taniguchi M,Yokoya A

    更新日期:2017-01-01 00:00:00

  • Analyses of local control and survival after stereotactic body radiotherapy for pulmonary oligometastases from colorectal adenocarcinoma.

    abstract::This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rraa071

    authors: Yamamoto T,Niibe Y,Matsumoto Y,Onishi H,Aoki M,Nishikawa A,Oh RJ,Shintani T,Yahara K,Ozaki M,Manabe Y,Jingu K

    更新日期:2020-11-16 00:00:00

  • Plutonium and uranium in human bones from areas surrounding the Semipalatinsk nuclear test site.

    abstract::To evaluate the present levels of 239,240Pu and U in residents living near the Semipalatinsk nuclear test site, more than 70 bone samples were obtained at autopsy. The subjects ranged in age from 30 to 86 years (mean 59.3+/-12.9). Most of the samples consisted of victims who died of various diseases. Plutonium and U w...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.47.a85

    authors: Yamamoto M,Hoshi M,Sakaguchi A,Shinohara K,Kurihara O,Apsalikov KN,Gusev BI

    更新日期:2006-02-01 00:00:00