Reassessment of the cancer mortality risk among Hiroshima atomic-bomb survivors using a new dosimetry system, ABS2000D, compared with ABS93D.


:The aim of the present study was to examine the excess relative risk for leukemia mortality and all cancers, except leukemia, among Hiroshima atomic-bomb survivors by applying ABS93D and ABS2000D. Particular attention was given to any difference in the neutron-dose estimates between the two dosimetry systems. The study subjects were 51,532 atomic-bomb survivors registered in a database of the Research Institute for Radiation Biology and Medicine of Hiroshima University (RIRBM). The results obtained by both dosimetry systems are similar: the excess relative risk per Sv for leukemia mortality and all cancers except leukemia is significantly higher compared to the control group. In addition, the difference in the excess relative risks between the two systems is not significant. Therefore, it is indicated that a modification of the neutron-dose estimates would not markedly change the conclusions about the cancer mortality risk.


J Radiat Res


Katayama H,Matsuura M,Endo S,Hoshi M,Ohtaki M,Hayakawa N





Has Abstract


2002-03-01 00:00:00












  • Preliminary study on radiosensitivity to carbon ions in human breast cancer.

    abstract::The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle dist...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Zhang Q,Kong Y,Yang Z,Liu Y,Liu R,Geng Y,Luo H,Zhang H,Li H,Feng S,Wang X

    更新日期:2020-05-22 00:00:00

  • A questionnaire-based survey on 3D image-guided brachytherapy for cervical cancer in Japan: advances and obstacles.

    abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

    更新日期:2015-11-01 00:00:00

  • p53-dependent signal transduction induced by stress.

    abstract::While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Wang X,Ohnishi T

    更新日期:1997-09-01 00:00:00

  • Alpha-particle fluence in radiobiological experiments.

    abstract::Two methods were proposed for determining alpha-particle fluence for radiobiological experiments. The first involved calculating the probabilities of hitting the target for alpha particles emitted from a source through Monte Carlo simulations, which when multiplied by the activity of the source gave the fluence at the...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Nikezic D,Yu KN

    更新日期:2017-03-01 00:00:00

  • Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction.

    abstract::In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on ce...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ogino H,Shibamoto Y,Sugie C,Ito M

    更新日期:2005-12-01 00:00:00

  • Microbeam studies of the bystander response.

    abstract::Microbeams have undergone a renaissance since their introduction and early use in the mid 60s. Recent advances in imaging, software and beam delivery have allowed rapid technological developments in microbeams for use in a range of experimental studies. The resurgence in the use of microbeams since the mid 90s has coi...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Prise KM,Schettino G,Vojnovic B,Belyakov O,Shao C

    更新日期:2009-03-01 00:00:00

  • Analysis of gene expression in a human-derived glial cell line exposed to 2.45 GHz continuous radiofrequency electromagnetic fields.

    abstract::The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Sakurai T,Kiyokawa T,Narita E,Suzuki Y,Taki M,Miyakoshi J

    更新日期:2011-01-01 00:00:00

  • Exposure to strong magnetic fields at power frequency potentiates X-ray-induced DNA strand breaks.

    abstract::We examined the effect of an extremely low-frequency magnetic field (ELFMF) at 5, 50 and 400 mT on DNA strand breaks in human glioma MO54 cells. A DNA damage analysis was performed using the method of alkaline comet assay. The cells were exposed to X-rays alone (5 Gy), ELFMF alone, or X-rays followed by ELFMF at 4 deg...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Miyakoshi J,Yoshida M,Shibuya K,Hiraoka M

    更新日期:2000-09-01 00:00:00

  • Effect of N-acetylcysteine on radiation-induced genotoxicity and cytotoxicity in rat bone marrow.

    abstract::The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Demirel C,Kilçiksiz S,Ay OI,Gürgül S,Ay ME,Erdal N

    更新日期:2009-01-01 00:00:00

  • Micronuclei formation induced by X-ray irradiation does not always result from DNA double-strand breaks.

    abstract::X-ray induced formation of micronuclei is generally thought to result from DNA double-strand breaks (DSBs). However, DNA DSBs inhibit the cell cycle progression that is required for micronucleus formation. In order to reconcile this apparent discrepancy, we investigated whether DNA DSBs induced during the G1 phase cou...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Okada T,Kashino G,Nishiura H,Tano K,Watanabe M

    更新日期:2012-01-01 00:00:00

  • A retrospective comparison of outcome and toxicity of preoperative image-guided intensity-modulated radiotherapy versus conventional pelvic radiotherapy for locally advanced rectal carcinoma.

    abstract::The aim of the study was to compare clinical outcomes and toxicity between 3D conformal radiotherapy (3DCRT) and image-guided intensity-modulated radiotherapy (IG-IMRT) administered through helical tomotherapy in locally advanced rectal cancer (LARC) patients receiving preoperative chemoradiotherapy. We reviewed 144 p...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Huang CM,Huang MY,Tsai HL,Huang CW,Ma CJ,Lin CH,Huang CJ,Wang JY

    更新日期:2017-03-01 00:00:00

  • Emerging connection between centrosome and DNA repair machinery.

    abstract::Centrosomes function in proper cell division in animal cells. The centrosome consists of a pair of centrioles and the surrounding pericentriolar matrix (PCM). After cytokinesis, daughter cells each acquire one centrosome, which subsequently duplicates at the G1/S phase in a manner that is dependent upon CDK2/cyclin-E ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Shimada M,Komatsu K

    更新日期:2009-07-01 00:00:00

  • DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus.

    abstract::To identify the repair dynamics involved in high linear energy transfer (LET) radiation-induced DNA damage, phospho-H2AX (gammaH2AX) foci formation was analyzed after cellular exposure to iron ions (Fe-ions, 500 MeV u(-1), 200 KeV microm(-1)). The foci located at DNA damage sites were visualized using immunocytochemic...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Takahashi A,Yamakawa N,Kirita T,Omori K,Ishioka N,Furusawa Y,Mori E,Ohnishi K,Ohnishi T

    更新日期:2008-11-01 00:00:00

  • Assessment of daily needle applicator displacement during high-dose-rate interstitial brachytherapy for prostate cancer using daily CT examinations.

    abstract::To improve treatment conformity for prostate cancer, we investigated daily applicator displacement during high-dose-rate interstitial brachytherapy (HDR-ISBT). Thirty patients treated with HDR-ISBT as monotherapy were examined. All patients received a treatment dosage of 49 Gy per 7 fractions over 4 days. For dose adm...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Takenaka T,Yoshida K,Ueda M,Yamazaki H,Miyake S,Tanaka E,Yoshida M,Yoshimura Y,Oka T,Honda K

    更新日期:2012-01-01 00:00:00

  • Induction of a germline mutation at a hypervariable mouse minisatellite locus by 252Cf radiation.

    abstract::Male C3H/HeN mice were exposed to 252Cf radiation and mated with unirradiated C57BL/6N females. F1 mice were analyzed for germline mutation at the paternally derived C3H/HeN allele of a hypervariable minisatellite locus, Ms6hm. This locus exhibited a high frequency of length change mutation spontaneously, and the muta...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Niwa O,Fan YJ,Numoto M,Kamiya K,Kominami R

    更新日期:1996-09-01 00:00:00

  • Preliminary survey of 3D image-guided brachytherapy for cervical cancer at representative hospitals in Asian countries.

    abstract::3D image-guided brachytherapy (3D-IGBT) has become a standard therapy for cervical cancer. However, the use of 3D-IGBT is limited in East and Southeast Asia. This study aimed to clarify the current usage patterns of 3D-IGBT for cervical cancer in East and Southeast Asia. A questionnaire-based survey was performed in 1...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Okonogi N,Wakatsuki M,Mizuno H,Fukuda S,Cao J,Kodrat H,Lau FN,Calaguas MJ,de Los Reyes RH,Chansilpa Y,Uddin AFMK,Adylkhanov T,Cho CK,Tsegmed U,Hoang NC,Ohno T,Nakano T,Kato S,Forum for Nuclear Cooperation in Asia.

    更新日期:2020-07-06 00:00:00

  • Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes.

    abstract::As a part of technical improvements of chromosome aberration analysis on human peripheral lymphocytes for biological radiation dosimetry, we examined the optimal conditions for the use of colcemid in chromosome preparation in order to obtain enough number of cells at metaphase in the first cell division. When treated ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Kanda R,Jiang T,Hayata I,Kobayashi S

    更新日期:1994-03-01 00:00:00

  • Vascular homeostasis regulators, Edn1 and Agpt2, are upregulated as a protective effect of heat-treated zinc yeast in irradiated murine bone marrow.

    abstract:PURPOSE:To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast). MATERIALS AND METHODS:Zn-yeast suspension was administered into C3H/He mice immediately after whole body irradiation (WBI) at 7.5 Gy. Bone marrow was extracted fr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ueno M,Imadome K,Iwakawa M,Anzai K,Ikota N,Imai T

    更新日期:2010-01-01 00:00:00

  • Quantifying biological effects of radiation from high-energy linear accelerators on lymphocytes.

    abstract::The aim of this study was to investigate the radiobiological effects of flattening filter (FF) and flattening filter-free (FFF) modes of linear electron accelerators and to understand whether there is any difference between the effects of these modes. We evaluated the number of chromosome aberrations following irradia...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Farkas G,Kocsis ZS,Székely G,Mihály D,Pesznyák C,Pócza T,Major T,Polgár C,Jurányi Z

    更新日期:2020-01-23 00:00:00

  • Retention, excretion and translocation of 239Pu in rats following inhalation of 239PuO2 calcined at 1150 and 400 degrees C.

    abstract::Wistar rats inhaled 239PuO2 particles prepared by the calcination of 239Pu hydroxide at 1150 and 400 degrees C. Lung retention, fecal and urinary excretion, and translocation of 239Pu were compared between the two calcination temperatures. The clearance of 239Pu from the lungs was significantly faster in the rats expo...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Sato H,Yamada Y,Ishigure N,Nakano T,Enomoto H,Takahashi S,Kubota Y,Inaba J

    更新日期:1999-06-01 00:00:00

  • Investigation of whether in-room CT-based adaptive intracavitary brachytherapy for uterine cervical cancer is robust against interfractional location variations of organs and/or applicators.

    abstract::This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiat...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

    更新日期:2016-11-01 00:00:00

  • Serum lactate dehydrogenase predicts survival in small-cell lung cancer patients with brain metastases that were treated with whole-brain radiotherapy.

    abstract::This study aimed to identify factors that predict prognosis after radiotherapy for brain metastases (BMs) from small-cell lung cancer (SCLC). This study retrospectively evaluated 48 consecutive patients who underwent whole-brain radiotherapy (WBRT) for BMs from SCLC between February 2008 and December 2017. WBRT was de...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Anami S,Doi H,Nakamatsu K,Uehara T,Wada Y,Fukuda K,Inada M,Ishikawa K,Kanamori S,Nishimura Y

    更新日期:2019-03-01 00:00:00

  • Assessing residual motion for gated proton-beam radiotherapy.

    abstract::Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to red...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Sharp GC,Lu HM,Trofimov A,Tang X,Jiang SB,Turcotte J,Gierga DP,Chen GT,Hong TS

    更新日期:2007-01-01 00:00:00

  • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Aging.

    abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Sasaki H,Kodama K,Yamada M

    更新日期:1991-03-01 00:00:00

  • Chromatin-regulating proteins as targets for cancer therapy.

    abstract::Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone acetyltransferases (HATs) and histone deacetylases (HDACs) play important roles in the repair of DNA double-strand breaks generated by ionizing...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审


    authors: Oike T,Ogiwara H,Amornwichet N,Nakano T,Kohno T

    更新日期:2014-07-01 00:00:00

  • Effects of interfractional anatomical changes on water-equivalent pathlength in charged-particle radiotherapy of lung cancer.

    abstract::Intrafractional motion and interfractional changes affect the accuracy of the delivered dose in radiotherapy, particularly in charged-particle radiotherapy. Most recent studies are focused on intrafractional motion (respiratory motion). Here, we report a quantitative simulation analysis of the effects of interfraction...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Mori S,Lu HM,Wolfgang JA,Choi NC,Chen GT

    更新日期:2009-11-01 00:00:00

  • Relative biological effectiveness of simulated solar particle event proton radiation to induce acute hematological change in the porcine model.

    abstract::The present study was undertaken to determine relative biological effectiveness (RBE) values for simulated solar particle event (SPE) radiation on peripheral blood cells using Yucatan minipigs and electron-simulated SPE as the reference radiation. The results demonstrated a generally downward trend in the RBE values w...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Sanzari JK,Wan SX,Diffenderfer ES,Cengel KA,Kennedy AR

    更新日期:2014-03-01 00:00:00

  • Percutaneous fiducial marker placement prior to stereotactic body radiotherapy for malignant liver tumors: an initial experience.

    abstract::The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Ohta K,Shimohira M,Murai T,Nishimura J,Iwata H,Ogino H,Hashizume T,Shibamoto Y

    更新日期:2016-03-01 00:00:00

  • Chromosomal aberrations in lymphocytes of lung cancer patients treated with carbon ions.

    abstract::The purpose of this study is to investigate the normal tissue damage caused by carbon-ion therapy. We measured chromosomal aberrations in peripheral blood lymphocytes before, during, and after radiotherapy, using the techniques of fluorescence in situ hybridization (FISH) and chemically induced premature chromosome co...

    journal_title:Journal of radiation research

    pub_type: 临床试验,杂志文章


    authors: Lee R,Yamada S,Yamamoto N,Miyamoto T,Ando K,Durante M,Tsujii H

    更新日期:2004-06-01 00:00:00

  • Recombinant human epidermal growth factor (rhEGF) protects radiation-induced intestine injury in murine system.

    abstract::This study was to investigate whether rhEGF protects radiation induced intestine injury without compromising antitumor effect of radiation in murine system. A radiation induced intestinal injury model was established in mice by whole body irradiation. Using this model, 4 groups were set; control, rhEGF (100 µg/kg intr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章


    authors: Oh H,Seong J,Kim W,Park S,Koom WS,Cho NH,Song M

    更新日期:2010-01-01 00:00:00