Investigation of whether in-room CT-based adaptive intracavitary brachytherapy for uterine cervical cancer is robust against interfractional location variations of organs and/or applicators.

Abstract:

:This study investigates whether in-room computed tomography (CT)-based adaptive treatment planning (ATP) is robust against interfractional location variations, namely, interfractional organ motions and/or applicator displacements, in 3D intracavitary brachytherapy (ICBT) for uterine cervical cancer. In ATP, the radiation treatment plans, which have been designed based on planning CT images (and/or MR images) acquired just before the treatments, are adaptively applied for each fraction, taking into account the interfractional location variations. 2D and 3D plans with ATP for 14 patients were simulated for 56 fractions at a prescribed dose of 600 cGy per fraction. The standard deviations (SDs) of location displacements (interfractional location variations) of the target and organs at risk (OARs) with 3D ATP were significantly smaller than those with 2D ATP (P < 0.05). The homogeneity index (HI), conformity index (CI) and tumor control probability (TCP) in 3D ATP were significantly higher for high-risk clinical target volumes than those in 2D ATP. The SDs of the HI, CI, TCP, bladder and rectum D2cc, and the bladder and rectum normal tissue complication probability (NTCP) in 3D ATP were significantly smaller than those in 2D ATP. The results of this study suggest that the interfractional location variations give smaller impacts on the planning evaluation indices in 3D ATP than in 2D ATP. Therefore, the 3D plans with ATP are expected to be robust against interfractional location variations in each treatment fraction.

journal_name

J Radiat Res

authors

Oku Y,Arimura H,Nguyen TT,Hiraki Y,Toyota M,Saigo Y,Yoshiura T,Hirata H

doi

10.1093/jrr/rrw043

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

677-683

issue

6

eissn

0449-3060

issn

1349-9157

pii

rrw043

journal_volume

57

pub_type

杂志文章
  • Effectiveness of carbon-ion beams for apoptosis induction in rat primary immature hippocampal neurons.

    abstract::The direct biological effects of radiation, particularly accelerated heavy particle ions, on neurons are not fully known. Hence, the direct effect of carbon-ion beams on immature neurons was investigated by comparing to the effect of X-rays in vitro using primary hippocampal neurons. Primary neurons were prepared from...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10050

    authors: Kaminuma T,Suzuki Y,Shirai K,Mizui T,Noda SE,Yoshida Y,Funayama T,Takahashi T,Kobayashi Y,Shirao T,Nakano T

    更新日期:2010-01-01 00:00:00

  • Risk factors for pericardial effusion after chemoradiotherapy for thoracic esophageal cancer-comparison of four-field technique and traditional two opposed fields technique.

    abstract::Pericardial effusion is an important late toxicity after concurrent chemoradiotherapy (CCRT) for locally advanced esophageal cancer. We investigated the clinical and dosimetric factors that were related to pericardial effusion among patients with thoracic esophageal cancer who were treated with definitive CCRT using t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rry029

    authors: Takata N,Kataoka M,Hamamoto Y,Tsuruoka S,Kanzaki H,Uwatsu K,Nagasaki K,Mochizuki T

    更新日期:2018-05-01 00:00:00

  • Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin.

    abstract::The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.46.215

    authors: Matsumoto Y,Machida H,Kubota N

    更新日期:2005-06-01 00:00:00

  • Protective roles of bacterioruberin and intracellular KCl in the resistance of Halobacterium salinarium against DNA-damaging agents.

    abstract::Halobacterium salinarium, a member of the extremely halophilic archaebacteria, contains a C50-carotenoid namely bacterioruberin. We have previously reported the high resistance of this organism against the lethal actions of DNA-damaging agents including ionizing radiation and ultraviolet light (UV). In this study, we ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.39.251

    authors: Shahmohammadi HR,Asgarani E,Terato H,Saito T,Ohyama Y,Gekko K,Yamamoto O,Ide H

    更新日期:1998-12-01 00:00:00

  • Involvement of reactive oxygen species in ionizing radiation-induced upregulation of cell surface Toll-like receptor 2 and 4 expression in human monocytic cells.

    abstract::Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and are indispensable for antibacterial and antiviral immunity. Our previous report showed that ionizing radiation increases the cell surface expressions of TLR2 and TLR4 and enhances their responses to a...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx011

    authors: Yoshino H,Kashiwakura I

    更新日期:2017-09-01 00:00:00

  • PCC-ring induction in human lymphocytes exposed to gamma and neutron irradiation.

    abstract::In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.0625

    authors: Lamadrid AI,García O,Delbos M,Voisin P,Roy L

    更新日期:2007-01-01 00:00:00

  • Radiation-induced bystander effect in non-irradiated glioblastoma spheroid cells.

    abstract::Radiation-induced bystander effects (RIBEs) are detected in cells that are not irradiated but receive signals from treated cells. The present study explored these bystander effects in a U87MG multicellular tumour spheroid model. A medium transfer technique was employed to induce the bystander effect, and colony format...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv039

    authors: Faqihi F,Neshastehriz A,Soleymanifard S,Shabani R,Eivazzadeh N

    更新日期:2015-09-01 00:00:00

  • Whole-pelvic radiotherapy with spot-scanning proton beams for uterine cervical cancer: a planning study.

    abstract::The aim of this study was to compare the dosimetric parameters of whole-pelvic radiotherapy (WPRT) for cervical cancer among plans involving 3D conformal radiotherapy (3D-CRT), intensity-modulated radiotherapy (IMRT), or spot-scanning proton therapy (SSPT). The dose distributions of 3D-CRT-, IMRT-, and SSPT-based WPRT...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw052

    authors: Hashimoto S,Shibamoto Y,Iwata H,Ogino H,Shibata H,Toshito T,Sugie C,Mizoe JE

    更新日期:2016-09-01 00:00:00

  • Optimized enzymatic dual functions of PaPrx protein by proton irradiation.

    abstract::We investigated the effects of proton irradiation on the function and structure of the Pseudomonas aeruginosa peroxiredoxin (PaPrx). Polyacrylamide gel demonstrated that PaPrx proteins exposed to proton irradiation at several doses exhibited simultaneous formation of high molecular weight (HMW) complexes and fragmenta...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt081

    authors: Park CH,Lee SS,Kim KR,Jung MH,Lee SY,Cho EJ,Singh S,Chung BY

    更新日期:2014-01-01 00:00:00

  • Radioprotective effect of chitosan in sub-lethally X-ray irradiated mice.

    abstract::The radioprotective effect of chitosan was studied in mice following whole-body X-ray irradiation. C3H/He mice were exposed to 7 Gy, and their survival rates were examined. The survival rates of chitosan-diet mice were about 20% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau a...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.44.53

    authors: Nishimura Y,Kim HS,Ikota N,Arima H,Bom HS,Kim YH,Watanabe Y,Yukawa M,Ozawa T

    更新日期:2003-03-01 00:00:00

  • Biological effects of field emission-type X-rays generated by nanotechnology.

    abstract::Thermionic emission (TE)-type X-ray generators have been exclusively used in medicine, but there are many difficulties in making these X-ray sources compact. A field emission (FE)-type X-ray generator using carbon nanotubes is a newly-developed compact system that can be as small as several cm in length. Considering t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.06071

    authors: Nakazato T,Nakanishi M,Kita S,Okuyama F,Shibamoto Y,Otsuka T

    更新日期:2007-03-01 00:00:00

  • Hypergravity modifies the signal transduction of ionizing radiation through p53.

    abstract::To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s261

    authors: Okaichi K,Usui A,Ohnishi T,Okumura Y

    更新日期:2002-12-01 00:00:00

  • Immunohistochemical study on cellular origins of rat lung tumors induced by inhalation exposures to plutonium dioxide aerosols as compared to those by X-ray irradiation.

    abstract::Immunohistochemical examinations were performed on rat pulmonary tumors induced by inhalation exposures to 239PuO2 aerosols, or by X-ray-irradiation to identify and compare cellular origins or, in turn, target cells at risk for radiation carcinogenesis. Both plutonium-induced and X-ray-induced pulmonary tumors appeare...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.301

    authors: Oghiso Y,Yamada Y

    更新日期:2002-09-01 00:00:00

  • A novel combination treatment of armed oncolytic adenovirus expressing IL-12 and GM-CSF with radiotherapy in murine hepatocarcinoma.

    abstract::In this study, a novel combination treatment of armed oncolytic adenovirus expressing interleukin 12 (IL-12) and granulocyte-macrophage colony-stimulating factor (GM-CSF) with radiation was investigated for antitumor and antimetastatic effect in a murine hepatic cancer (HCa-I) model. Tumor bearing syngeneic mice were ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10185

    authors: Kim W,Seong J,Oh HJ,Koom WS,Choi KJ,Yun CO

    更新日期:2011-01-01 00:00:00

  • High-dose antibiotic therapy is superior to a 3-drug combination of prostanoids and lipid A derivative in protecting irradiated canines.

    abstract::There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-D...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.361

    authors: Kumar KS,Srinivasan V,Toles RE,Miner VL,Jackson WE,Seed TM

    更新日期:2002-12-01 00:00:00

  • A novel method of boron delivery using sodium iodide symporter for boron neutron capture therapy.

    abstract::Boron Neutron Capture Therapy (BNCT) effectiveness depends on the preferential sequestration of boron in cancer cells relative to normal tissue cells. We present a novel strategy for sequestering boron using an adenovirus expressing the sodium iodide symporter (NIS). Human glioma grown subcutaneously in athymic mice a...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10036

    authors: Kumar S,Freytag SO,Barton KN,Burmeister J,Joiner MC,Sedghi B,Movsas B,Binns PJ,Kim JH,Brown SL

    更新日期:2010-01-01 00:00:00

  • A questionnaire-based survey on 3D image-guided brachytherapy for cervical cancer in Japan: advances and obstacles.

    abstract::The purpose of this study is to survey the current patterns of practice, and barriers to implementation, of 3D image-guided brachytherapy (3D-IGBT) for cervical cancer in Japan. A 30-item questionnaire was sent to 171 Japanese facilities where high-dose-rate brachytherapy devices were available in 2012. In total, 135 ...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrv047

    authors: Ohno T,Toita T,Tsujino K,Uchida N,Hatano K,Nishimura T,Ishikura S

    更新日期:2015-11-01 00:00:00

  • The LD50 associated with exposure to the atomic bombing of Hiroshima and Nagasaki.

    abstract::Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was igno...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_154

    authors: Fujita S,Kato H,Schull WJ

    更新日期:1991-03-01 00:00:00

  • Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.

    abstract::When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.43.s209

    authors: Kato F,Kakihara H,Kunugita N,Ootsuyama A,Norimura T

    更新日期:2002-12-01 00:00:00

  • Modeling cell survival and change in amount of DNA during protracted irradiation.

    abstract::Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrw110

    authors: Matsuya Y,Tsutsumi K,Sasaki K,Yoshii Y,Kimura T,Date H

    更新日期:2017-05-01 00:00:00

  • Radiotherapy for localized sebaceous carcinoma of the eyelid: a retrospective analysis of 83 patients.

    abstract::The current study retrospectively analyzed the results of radiotherapy for clinically localized sebaceous carcinoma of the eyelid.We reviewed records of 83 patients with histologically confirmed sebaceous carcinoma who were treated radiotherapeutically between 1983 and 2015. Sixty-five patients (78%) were initially tr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrz046

    authors: Takagawa Y,Tamaki W,Suzuki S,Inaba K,Murakami N,Takahashi K,Igaki H,Nakayama Y,Shigematsu N,Itami J

    更新日期:2019-10-23 00:00:00

  • Clinical outcomes of 125I brachytherapy with and without external-beam radiation therapy for localized prostate cancer: results from 300 patients at a single institution in Japan.

    abstract::The aim of this study was to determine the outcomes and adverse events for 300 men with prostate cancer treated with 125iodine (125I) brachytherapy with and without external-beam radiation therapy (EBRT) at a single institution in Japan. Between February 2005 and November 2011, 300 consecutive patients with clinically...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx051

    authors: Maki S,Itoh Y,Kubota S,Okada T,Nakahara R,Ito J,Kawamura M,Naganawa S,Yoshino Y,Fujita T,Kato M,Gotoh M,Ikeda M

    更新日期:2017-11-01 00:00:00

  • A novel monofunctional DNA glycosylase activity against thymine glycol in mouse cell nuclei.

    abstract::Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.07100

    authors: Yamamoto R,Akiyama M,Ide H,Yamamoto K,Matsuyama S,Kubo K

    更新日期:2008-05-01 00:00:00

  • Transfer of plutonium to rat embryos in vivo and in vitro.

    abstract::The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.33.301

    authors: Takahashi S,Sato H,Kubota Y,Inaba J

    更新日期:1992-12-01 00:00:00

  • Kinetic analysis of double-strand break rejoining reveals the DNA reparability of gamma-irradiated tobacco cultured cells.

    abstract::The rejoining efficiency of double-strand breaks (DSBs) was quantified by a DNA fragment-size analysis in tobacco protoplasts and CHO-K1 cells following gamma-ray irradiation in order to compare DNA reparability of higher plants with mammals. Results showed that the DSB rejoining efficiency of tobacco protoplasts is d...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.08064

    authors: Yokota Y,Wada S,Hase Y,Funayama T,Kobayashi Y,Narumi I,Tanaka A

    更新日期:2009-03-01 00:00:00

  • The role of nitric oxide radicals in removal of hyper-radiosensitivity by priming irradiation.

    abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrt061

    authors: Edin NJ,Sandvik JA,Vollan HS,Reger K,Görlach A,Pettersen EO

    更新日期:2013-11-01 00:00:00

  • Radiation chemical studies on thermosensitive N-isopropylacrylamide and its polymer in aqueous solutions.

    abstract::The pulse radiolysis technique has been employed to determine the initiation and propagation rates of different transient species involved in the polymerization of N-isopropylacrylamide (NIPA) in aqueous solutions. Polymerization by anionic mechanism has been observed to be faster than by the free-radical mechanism. T...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.44.335

    authors: Acharya A,Mohan H,Sabharwal S

    更新日期:2003-12-01 00:00:00

  • A review of forty-five years study of Hiroshima and Nagasaki atomic bomb survivors. Aging.

    abstract::The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bom...

    journal_title:Journal of radiation research

    pub_type: 杂志文章,评审

    doi:10.1269/jrr.32.supplement_310

    authors: Sasaki H,Kodama K,Yamada M

    更新日期:1991-03-01 00:00:00

  • General ion recombination effect in a liquid ionization chamber in high-dose-rate pulsed photon and electron beams.

    abstract::Liquid ionization chambers (LICs) are highly sensitive to dose irradiation and have small perturbations because of their liquid-filled sensitive volume. They require a sensitive volume much smaller than conventional air-filled chambers. However, it has been reported that the collection efficiency has dependencies on t...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1093/jrr/rrx088

    authors: Takei H,Isobe T,Kitamura N,Mori Y,Tomita T,Kobayashi D,Kamizawa S,Sato T,Sakurai H,Sakae T

    更新日期:2018-05-01 00:00:00

  • Vascular homeostasis regulators, Edn1 and Agpt2, are upregulated as a protective effect of heat-treated zinc yeast in irradiated murine bone marrow.

    abstract:PURPOSE:To elucidate the mechanism underlying the in vivo radioprotection activity by Zn-containing, heat-treated Saccharomyces cerevisiae yeast (Zn-yeast). MATERIALS AND METHODS:Zn-yeast suspension was administered into C3H/He mice immediately after whole body irradiation (WBI) at 7.5 Gy. Bone marrow was extracted fr...

    journal_title:Journal of radiation research

    pub_type: 杂志文章

    doi:10.1269/jrr.10005

    authors: Ueno M,Imadome K,Iwakawa M,Anzai K,Ikota N,Imai T

    更新日期:2010-01-01 00:00:00