Megakaryocytic differentiation in human chronic myelogenous leukemia K562 cells induced by ionizing radiation in combination with phorbol 12-myristate 13-acetate.

abstract：:We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irrad...

journal_title：Journal of radiation research

authors： Oya N,Sasai K,Shibata T,Takagi T,Shibuya K,Koike S,Nojima K,Furusawa Y,Ando K,Hiraoka M

更新日期：2001-06-01 00:00:00

abstract：:We examined the use of the mouse Pc-3 ESTR (expanded simple tandem repeat) locus and 72 human microsatellite loci as potentially sensitive biomarkers for mutagenic exposures to germ cells in mice and humans respectively. In the mouse work, we treated male mice with TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin; a chemi...

journal_title：Journal of radiation research

authors： Ryo H,Nakajima H,Nomura T

更新日期：2006-01-01 00:00:00

abstract：:The aim of this study was to describe our initial experience with a gold flexible linear fiducial marker and to evaluate the safety and technical and clinical efficacy of stereotactic body radiotherapy using this marker for malignant liver tumors. Between July 2012 and February 2015, 18 patients underwent percutaneous...

journal_title：Journal of radiation research

authors： Ohta K,Shimohira M,Murai T,Nishimura J,Iwata H,Ogino H,Hashizume T,Shibamoto Y

更新日期：2016-03-01 00:00:00

abstract：:The quality of the sublethal damage (SLD) after irradiation with high-linear energy transfer (LET) ion beams was investigated with low-LET photons. Chinese hamster V79 cells and human squamous carcinoma SAS cells were first exposed to a priming dose of different ion beams at different LETs at the Heavy Ion Medical Acc...

journal_title：Journal of radiation research

authors： Furusawa Y,Nakano-Aoki M,Matsumoto Y,Hirayama R,Kobayashi A,Konishi T

更新日期：2017-11-01 00:00:00

abstract：:This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...

journal_title：Journal of radiation research

authors： Hamatani N,Sumida I,Takahashi Y,Oda M,Seo Y,Isohashi F,Tamari K,Ogawa K

更新日期：2017-09-01 00:00:00

abstract：:The purpose of this study was to evaluate the efficacy and toxicity of radiotherapy concurrently with weekly cisplatin, followed by adjuvant chemotherapy, for the treatment of N2-3 nasopharyngeal cancer (NPC) in Asian countries, especially regions of South and Southeast Asian countries where NPC is endemic. Between 20...

journal_title：Journal of radiation research

authors： Ohno T,Thinh DH,Kato S,Devi CR,Tung NT,Thephamongkhol K,Calaguas MJ,Zhou J,Chansilpa Y,Supriana N,Erawati D,Banu PA,Koo CC,Kobayashi K,Nakano T,Tsujii H

更新日期：2013-05-01 00:00:00

abstract：:The biokinetics of radon in the body has previously been studied with the assumption that its absorption through the skin is negligibly small. This assumption would be acceptable except in specific situations, such as bathing in a radon hot spring where the radon concentration in thermal water is far higher than that ...

journal_title：Journal of radiation research

authors： Sakoda A,Ishimori Y,Tschiersch J

更新日期：2016-07-01 00:00:00

abstract：:A synergistic interaction of hyperthermia with ionizing or UV light (254 nm) radiation was analyzed in experiments with yeast cells. For a fixed dose rate of radiation, the synergism was shown to be observed only within a definite temperature range (40-45 degrees C), inside of which there was an optimal temperature to...

journal_title：Journal of radiation research

authors： Kim JK,Petin VG,Zhurakovskaya GP

更新日期：2001-12-01 00:00:00

abstract：:Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

journal_title：Journal of radiation research

authors： Yonezawa M,Takeda A,Misonoh J

更新日期：1990-09-01 00:00:00

abstract：:Herein we summarize the public health actions taken to mitigate exposure of the public to radiation after the Fukushima accident that occurred on 11 March 2011 in order to record valuable lessons learned for disaster preparedness. Evacuations from the radiation-affected areas and control of the distribution of various...

journal_title：Journal of radiation research

authors： Shimura T,Yamaguchi I,Terada H,Robert Svendsen E,Kunugita N

更新日期：2015-05-01 00:00:00

abstract：:External beam radiotherapy is a potential salvage or adjuvant therapy after radical prostatectomy (RP). The purpose of this study was to investigate the treatment outcome of salvage radiotherapy (RT) following RP for clinically localized prostate cancer and to identify factors that may predict the outcome of salvage R...

journal_title：Journal of radiation research

authors： Hayashi S,Hayashi K,Yoshimura R,Masuda H,Kihara K,Shibuya H

更新日期：2012-09-01 00:00:00

abstract：:The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...

journal_title：Journal of radiation research

authors： Tang JM,Ma XM,Hou YL,Dai LY,Cao HB,Ye M,Bai YR

更新日期：2014-07-01 00:00:00

abstract：:Intrafractional motion and interfractional changes affect the accuracy of the delivered dose in radiotherapy, particularly in charged-particle radiotherapy. Most recent studies are focused on intrafractional motion (respiratory motion). Here, we report a quantitative simulation analysis of the effects of interfraction...

journal_title：Journal of radiation research

authors： Mori S,Lu HM,Wolfgang JA,Choi NC,Chen GT

更新日期：2009-11-01 00:00:00

abstract：:Estimation of the relative biological effectiveness (RBE) of the proton beam at the National Cancer Center Proton Therapy Center in Korea (NCCPTC) is required clinically for the treatment of cancer. The proton beam was fixed at 190 MeV with 6 cm a spread out Bragg peaks (SOBP) for which corresponds to most frequent cl...

journal_title：Journal of radiation research

authors： Baek HJ,Kim TH,Shin D,Kwak JW,Choo DW,Lee SB,Furusawa Y,Ando K,Kim SS,Cho KH

更新日期：2008-09-01 00:00:00

abstract：:Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...

journal_title：Journal of radiation research

authors： Matsuya Y,Tsutsumi K,Sasaki K,Yoshii Y,Kimura T,Date H

更新日期：2017-05-01 00:00:00

abstract：:The multifraction regimens commonly used in conventional clinical radiotherapy are largely based on radiobiological experiments. However, no experimental reports on skin reactions focusing on inter-strain differences have displayed clinical relevance to the fractionated dose schedule. In this study, mice of inbred str...

journal_title：Journal of radiation research

authors： Ohta T,Iwakawa M,Oohira C,Noda S,Minfu Y,Goto M,Tanaka H,Harada Y,Imai T

更新日期：2004-12-01 00:00:00

abstract：:The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...

journal_title：Journal of radiation research

authors： Ohkubo Y,Ohno T,Noda SE,Kubo N,Nakagawa A,Kawahara M,Abe T,Kiyohara H,Wakatsuki M,Nakano T

更新日期：2013-11-01 00:00:00

abstract：:Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...

journal_title：Journal of radiation research

authors： Shinsuke K,Junya K,Tomonobu U,Yoshiko K,Izumo N,Takahiko S

更新日期：2017-11-01 00:00:00

abstract：:Various kinases, such as tyrosine, protein kinase C (PKC) and MAP kinase, play important role in the cellular response to radiation, but little is known about the specific response in the whole animal. Most studies, except a few, are based on single cells. There is a paucity of data where signaling following whole bod...

journal_title：Journal of radiation research

authors： Varadkar PA,Krishna M

更新日期：2004-03-01 00:00:00

abstract：:The yield of OH radical induced by ionizing radiation was estimated by an empirical model; a prescribed diffusion model for a spur of single size applying to neutral water. Two representative spur distances were introduced, one for an incident primary charged particle and one for a representative secondary electron, t...

journal_title：Journal of radiation research

authors： Yamaguchi H,Uchihori Y,Yasuda N,Takada M,Kitamura H

更新日期：2005-09-01 00:00:00

abstract：:To assess the mutational effects of radiation on vigorously proliferating plant tissue, the mutation spectrum was analyzed with Arabidopsis seedlings using the plasmid-rescue method. Transgenic plants containing the Escherichia coli rpsL gene were irradiated with γ-rays and carbon ion beams (320-MeV (12)C(6+)), and mu...

journal_title：Journal of radiation research

authors： Yoshihara R,Nozawa S,Hase Y,Narumi I,Hidema J,Sakamoto AN

更新日期：2013-11-01 00:00:00

abstract：:X-ray induced neoplastic transformation of C3H/10T1/2 cells was suppressed equally by Lipid A and LPS. We examined the effects of several modifiers of arachidonic acid (AA) metabolism in our investigation on the suppression mechanism of LPS. Dexamethasone (DM), an inhibitor of phospholipase A2 (PLA2), abolished the ef...

journal_title：Journal of radiation research

authors： Sakiyama H,Yasukawa M,Nishijima M,Wada E,Kanegasaki S

更新日期：1993-12-01 00:00:00

abstract：:We aimed to investigate the effect of chronic radiation exposure associated with the Fukushima Daiichi Nuclear Power Plant (FNPP) accident on the testes of boar and inobuta (a hybrid of Sus scrofa and Sus scrofa domestica). This study examined the contamination levels of radioactive caesium (Cs), especially (134)Cs an...

journal_title：Journal of radiation research

authors： Yamashiro H,Abe Y,Hayashi G,Urushihara Y,Kuwahara Y,Suzuki M,Kobayashi J,Kino Y,Fukuda T,Tong B,Takino S,Sugano Y,Sugimura S,Yamada T,Isogai E,Fukumoto M

更新日期：2015-12-01 00:00:00

abstract：:The expression of oncogenes was studied in 12 types of 178 mouse tumors induced by radiations and chemicals. DNA was analyzed in tumors in which the overexpression of oncogenes was noted. Amplification of the myc oncogene was found in chemically induced sarcomas, but not in sarcomas induced by radiation. Activation of...

journal_title：Journal of radiation research

authors： Niwa O,Muto M,Suzuki F,Kominami R,Yokoro K

更新日期：1991-12-01 00:00:00

abstract：:To analyze the biological effects of the space environment, we flew nine lines of rice seeds on the Chinese 20(th) recoverable satellite for a duration of 18 days. The same lines of seeds were also irradiated to low doses (2.0 mGy) of Carbon, or Neon or Iron ions (with different LET value of 13.3 keV/microm, 31 keV/mi...

journal_title：Journal of radiation research

authors： Wei LJ,Yang Q,Xia HM,Furusawa Y,Guan SH,Xin P,Sun YQ

更新日期：2006-11-01 00:00:00

abstract：:The 239Pu distribution in the 12.5-day-old rat conceptus was compared between in vivo and in vitro experimental systems to establish a possible mechanism of cross-placental transfer of this radionuclide. In the in vivo study, plutonium citrate solution was injected intravenously to pregnant Wistar rats. In the in vitr...

journal_title：Journal of radiation research

authors： Takahashi S,Sato H,Kubota Y,Inaba J

更新日期：1992-12-01 00:00:00

abstract：:Male C3H/HeN mice were exposed to 252Cf radiation and mated with unirradiated C57BL/6N females. F1 mice were analyzed for germline mutation at the paternally derived C3H/HeN allele of a hypervariable minisatellite locus, Ms6hm. This locus exhibited a high frequency of length change mutation spontaneously, and the muta...

journal_title：Journal of radiation research

authors： Niwa O,Fan YJ,Numoto M,Kamiya K,Kominami R

更新日期：1996-09-01 00:00:00

abstract：:Brain metastasis from esophageal carcinoma has been considered rare and survival following esophageal carcinoma with distant metastasis is poor. The purpose of this report was to clarify cumulative incidence and risk factors for brain metastasis after chemoradiotherapy for esophageal carcinoma, and to consider recomme...

journal_title：Journal of radiation research

authors： Kanemoto A,Hashimoto T,Harada H,Asakura H,Ogawa H,Furutani K,Boku N,Nakasu Y,Nishimura T

更新日期：2011-01-01 00:00:00

abstract：:PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms of tumor-specific radiosensitizat...

journal_title：Journal of radiation research

authors： Li HK,Matsumoto Y,Furusawa Y,Kamada T

更新日期：2016-09-01 00:00:00

abstract：:The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...

journal_title：Journal of radiation research

authors： Demirel C,Kilçiksiz S,Ay OI,Gürgül S,Ay ME,Erdal N

更新日期：2009-01-01 00:00:00