Effect of N-acetylcysteine on radiation-induced genotoxicity and cytotoxicity in rat bone marrow.

abstract：:To evaluate the feasibility of using radiosensitivity of peripheral leukocytes as a predictor of clinical therapeutic responses to radiosurgery in individuals with cerebral arteriovenous malformation (AVM), we enrolled 18 patients years after they had received Gamma Knife radiosurgery for their cerebral AVM. The AVMs ...

journal_title：Journal of radiation research

authors： Guo WY,Pan HC,Wu HM,Hsieh WA,Tsai MH,Chow YM,Chung WY,Shiau CY,Chen SK,Chang WP

更新日期：2004-06-01 00:00:00

abstract：:Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...

journal_title：Journal of radiation research

authors： Yonezawa M,Takeda A,Misonoh J

更新日期：1990-09-01 00:00:00

abstract：:Non-homologous end-joining (NHEJ) is the predominant pathway for the repair of DNA double-strand breaks (DSBs) in human cells. XRCC4 is indispensable to NHEJ and functions together with DNA ligase IV in the rejoining of broken DNA ends. Artemis is a nuclease required for trimming of some, but not all, types of broken ...

journal_title：Journal of radiation research

authors： Katsube T,Mori M,Tsuji H,Shiomi T,Shiomi N,Onoda M

更新日期：2011-01-01 00:00:00

abstract：:Direct irradiation may cause malfunctioning of cardiac implantable electronic devices (CIEDs). Therefore, a treatment plan that does not involve direct irradiation of CIEDs should be formulated. However, CIEDs may be directly exposed to radiation because of the sudden intrafractional movement of the patient. The proba...

journal_title：Journal of radiation research

authors： Nakamura K,Aoyama T,Kaneda N,Otsuji M,Minami Y,Sakuragi A,Nakamura M

更新日期：2020-05-22 00:00:00

abstract：:The purpose of the study was to quantify local setup errors and evaluate the planning target volume (PTV) margins for sub-regions in cone-beam computed tomography (CBCT)-guided post-mastectomy radiation therapy (PMRT). The local setup errors of 20 patients undergoing CBCT-guided PMRT were analysed retrospectively. Ima...

journal_title：Journal of radiation research

authors： Zhou J,Li S,Ye C,Shen K,Li A,Chen G,Li X,Bai S,Wang W,Zhong R

更新日期：2020-05-22 00:00:00

abstract：:Tumor hypoxia and angiogenesis have been studied extensively. However, the relation between normal tissue injury and hypoxia is still unclear. In this study, we investigated the effect of hypoxia on radiation-induced late rectal injury in mice. The rectum of C57BL/6N mice was irradiated locally with a single dose of 2...

journal_title：Journal of radiation research

authors： Liu Y,Kudo K,Abe Y,Aoki M,Hu DL,Kijima H,Nakane A

更新日期：2008-05-01 00:00:00

abstract：:This study investigated the radioprotective effect of Sipunculus nudus L. polysaccharide (SNP) in combination with WR-2721, rhIL-11 and rhG-CSF on irradiated mice. A total of 70 Imprinting Control Region (ICR) mice were divided into seven groups: the control group, the model group and five administration groups. All g...

journal_title：Journal of radiation research

authors： Jiang S,Shen X,Liu Y,He Y,Jiang D,Chen W

更新日期：2015-05-01 00:00:00

abstract：:The purpose of this study was to compare single-arc (SA) and double-arc (DA) treatment plans, which are planning techniques often used in prostate cancer volumetric modulated arc therapy (VMAT), in the presence of intrafractional deformation (ID) to determine which technique is superior in terms of target dose coverag...

journal_title：Journal of radiation research

authors： Varnava M,Sumida I,Oda M,Kurosu K,Isohashi F,Seo Y,Otani K,Ogawa K

更新日期：2020-12-21 00:00:00

abstract：:In Japan, the use of adjuvant radiotherapy after prostatectomy for prostate cancer has not increased compared with the use of salvage radiotherapy. We retrospectively evaluated the outcome of adjuvant radiotherapy together with prognostic factors of outcome in Japan. Between 2005 and 2007, a total of 87 patients were ...

journal_title：Journal of radiation research

authors： Aoki M,Mizowaki T,Akimoto T,Nakamura K,Ejima Y,Jingu K,Tamai Y,Nakajima N,Takemoto S,Kokubo M,Katoh H

更新日期：2014-05-01 00:00:00

abstract：:Investigating the biological effects of high-LET heavy-ion irradiation at low fluence is important to evaluate the risk of radiation in space. It is especially necessary to detect radiation damage induced by a precise number of heavy ions in individual cells. We thus compared the number of ions traversing a cell and t...

journal_title：Journal of radiation research

authors： Wada S,Kobayashi Y,Funayama T,Natsuhori M,Ito N,Yamamoto K

更新日期：2002-12-01 00:00:00

abstract：:This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...

journal_title：Journal of radiation research

authors： Yin Z,Deng S,Liang Z,Wang Q

更新日期：2016-09-01 00:00:00

abstract：:The purpose of this study was to investigate the radiosensitizing effect of geldanamycin (GA), an inhibitor of heat shock protein 90, on tumour cells and normal cells. We tested the effect of a combination of GA and radiation on cell survival, PI3K/Akt-related proteins and apoptosis induction. GA sensitized tumour cel...

journal_title：Journal of radiation research

authors： Matsumoto Y,Machida H,Kubota N

更新日期：2005-06-01 00:00:00

abstract：:The aim of the present study was to examine the excess relative risk for leukemia mortality and all cancers, except leukemia, among Hiroshima atomic-bomb survivors by applying ABS93D and ABS2000D. Particular attention was given to any difference in the neutron-dose estimates between the two dosimetry systems. The stud...

journal_title：Journal of radiation research

authors： Katayama H,Matsuura M,Endo S,Hoshi M,Ohtaki M,Hayakawa N

更新日期：2002-03-01 00:00:00

abstract：:This study was designed to elucidate the dose-response relationships for life-shortening and tumorigenic effect in the dose range below 1 Gy of gamma rays delivered during the infant period. Female B6C3F1 mice were irradiated with 0.10, 0.48 or 0.95 Gy at 7 days of age. All irradiated mice were allowed to live out the...

journal_title：Journal of radiation research

authors： Sasaki S,Fukuda N

更新日期：2006-06-01 00:00:00

abstract：:Chronic irradiation with low-dose-rate 137Cs-γ rays inhibits the differentiation of human neural progenitor cells and influences the expression of proteins associated with several cellular functions. We aimed to determine whether such chronic irradiation influences the expression of proteins associated with PC12 cells...

journal_title：Journal of radiation research

authors： Shinsuke K,Junya K,Tomonobu U,Yoshiko K,Izumo N,Takahiko S

更新日期：2017-11-01 00:00:00

abstract：:To determine the patterns of gene expression responsible for the radiosensitivity of glioblastoma cells, we analyzed transcriptional changes after ionizing radiation in different cell lines. After completing clonogenic survival assays, we selected two glioblastoma cell lines with different radiosensitivities. Subseque...

journal_title：Journal of radiation research

authors： Otomo T,Hishii M,Arai H,Sato K,Sasai K

更新日期：2004-03-01 00:00:00

abstract：:The aim of the study was to evaluate inter-fractional dosimetric variations for high-dose rate breast brachytherapy using a strut-adjusted volume implant (SAVI). For the nine patients included, dosimetric constraints for treatment were as follows: for the planning target volume for evaluation (PTV_Eval), the volume re...

journal_title：Journal of radiation research

authors： Iijima K,Okamoto H,Takahashi K,Aikawa A,Wakita A,Nakamura S,Nishioka S,Harada K,Notake R,Sugawara A,Yoshimura R,Kunieda E,Itami J

更新日期：2020-01-23 00:00:00

abstract：:This study is a subset analysis of a retrospective multicenter study performed in Japan and its purpose was to investigate the effectiveness of stereotactic body radiotherapy (SBRT) for pulmonary oligometastases from colorectal cancer. Local control (LC), freedom from further metastases, relapse-free survival and over...

journal_title：Journal of radiation research

authors： Yamamoto T,Niibe Y,Matsumoto Y,Onishi H,Aoki M,Nishikawa A,Oh RJ,Shintani T,Yahara K,Ozaki M,Manabe Y,Jingu K

更新日期：2020-11-16 00:00:00

abstract：:The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...

journal_title：Journal of radiation research

authors： Romero I,García O,Lamadrid AI,Gregoire E,González JE,Morales W,Martin C,Barquinero JF,Voisin P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...

journal_title：Journal of radiation research

authors： Hirano E,Fuji H,Onoe T,Kumar V,Shirato H,Kawabuchi K

更新日期：2014-03-01 00:00:00

abstract：:A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...

journal_title：Journal of radiation research

authors： Hu Z,Xing Y,Qian Y,Chen X,Tu J,Ren L,Wang K,Chen Z

更新日期：2013-03-01 00:00:00

abstract：:PU-H71, a heat shock protein 90 (Hsp90) inhibitor, has yielded therapeutic efficacy in many preclinical models and is currently in clinical trials. Carbon-ion radiotherapy (CIRT) has provided successful tumor control; however, there is still room for improvement, particularly in terms of tumor-specific radiosensitizat...

journal_title：Journal of radiation research

authors： Li HK,Matsumoto Y,Furusawa Y,Kamada T

更新日期：2016-09-01 00:00:00

abstract：:Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...

journal_title：Journal of radiation research

authors： Matsuya Y,Tsutsumi K,Sasaki K,Yoshii Y,Kimura T,Date H

更新日期：2017-05-01 00:00:00

abstract：:This study aimed to evaluate the relationship between cardiac toxicity after definitive chemoradiotherapy (CRT) for esophageal cancer and the dose-volume histogram (DVH) of organs at risk (OARs) [using biological effective dose (BED)]. We analyzed the data of 83 patients with esophageal cancer treated using definitive...

journal_title：Journal of radiation research

authors： Takeuchi Y,Murakami Y,Kameoka T,Ochi M,Imano N,Takahashi I,Nishibuchi I,Kimura T,Kawahara D,Saito A,Nagata Y

更新日期：2020-03-23 00:00:00

abstract：:The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...

journal_title：Journal of radiation research

authors： Uehara S,Nikjoo H

更新日期：2006-03-01 00:00:00

abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...

journal_title：Journal of radiation research

authors： Tao Z,Zha Y,Akiba S,Sun Q,Zou J,Li J,Liu Y,Kato H,Sugahara T,Wei L

更新日期：2000-10-01 00:00:00

abstract：:A conceptual design of a mobile isocenter carbon ion gantry was carried out in the framework of the Particle Training Network for European Radiotherapy (PARTNER) and Union of Light Ion Centres in Europe (ULICE) projects. To validate the magnets used in this gantry, Finite Element Method (FEM) simulations were performe...

journal_title：Journal of radiation research

authors： Moreno JO,Pullia MG,Priano C,Lante V,Necchi MM,Savazzi S

更新日期：2013-07-01 00:00:00

abstract：:3D image-guided brachytherapy (3D-IGBT) has become a standard therapy for cervical cancer. However, the use of 3D-IGBT is limited in East and Southeast Asia. This study aimed to clarify the current usage patterns of 3D-IGBT for cervical cancer in East and Southeast Asia. A questionnaire-based survey was performed in 1...

journal_title：Journal of radiation research

authors： Okonogi N,Wakatsuki M,Mizuno H,Fukuda S,Cao J,Kodrat H,Lau FN,Calaguas MJ,de Los Reyes RH,Chansilpa Y,Uddin AFMK,Adylkhanov T,Cho CK,Tsegmed U,Hoang NC,Ohno T,Nakano T,Kato S,Forum for Nuclear Cooperation in Asia.

更新日期：2020-07-06 00:00:00

abstract：:Exposure to ionizing radiation leads to severe damages in radiosensitive organs and induces acute radiation syndrome, including effects on the hematopoietic system and gastrointestinal system. In this study, the radioprotective ability of KMRC011, a novel toll-like receptor 5 (TLR5) agonist, was investigated in C57BL6...

journal_title：Journal of radiation research

authors： Kim JY,Park JH,Seo SM,Park JI,Jeon HY,Lee HK,Yoo RJ,Lee YJ,Woo SK,Lee WJ,Choi CM,Choi YK

更新日期：2019-07-01 00:00:00

abstract：:Before the sorafenib era, advanced but liver-confined hepatocellular carcinoma (HCC) was treated by liver-directed therapy. Hepatic arterial concurrent chemoradiotherapy (CCRT) has been performed in our group, giving substantial local control but frequent failure. The aim of this study was to analyze patterns of failu...

journal_title：Journal of radiation research

authors： Cha H,Yoon HI,Lee IJ,Koom WS,Han KH,Seong J

更新日期：2013-11-01 00:00:00