Abstract:
:Perirectal hyaluronate gel injection (HGI) appears to be a promising technique for healthy tissue dose sparing in pelvic radiotherapy. In this analysis, we report our initial experience of HGI in gynecologic brachytherapy, focusing on its safety and effectiveness for dose reduction to the rectum. Between July 2013 and May 2014, 36 patients received HGI for primary/salvage gynecologic brachytherapy. Dosimetric effect analysis was based on pre- and post-HGI computed tomography dataset registration with corresponding dose-volume histogram evaluation. The maximum dose to the most exposed 0.1 cm3 (D0.1cm3) and 2.0 cm3 (D2.0cm3) were used as index values for rectum and bladder dose evaluation. The dose indexes for target volume (TV) coverage were TV D90/V100. In all cases, HGI was well tolerated, with no acute or late adverse events documented at a median follow-up of 220 days (range, 18-1046 days). Rectum D2.0cm3 and D0.1cm3 were significantly decreased by HGI (P < 0.001 and P = 0.003, respectively), with no significant impact on dosimetric parameters of bladder and TV coverage. Factors correlating negatively with the dosimetric effect of HGI were an increasing number of interstitial catheters (P = 0.003) as well as Lcranial100% (P = 0.014) and Lcranial80% (P = 0.001) [i.e. the length from the anal verge to the most cranial point at which the 100% and 80% isodose lines, respectively, crossed the rectum]. The concept of HGI for gynecologic brachytherapy is plausible, and our initial experience indicates it to be an effective technique for rectal dose reduction in radiotherapy of intrapelvic tumours.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Kashihara T,Murakami N,Tselis N,Kobayashi K,Tsuchida K,Shima S,Masui K,Yoshida K,Takahashi K,Inaba K,Umezawa R,Igaki H,Ito Y,Kato T,Uno T,Itami Jdoi
10.1093/jrr/rrz016subject
Has Abstractpub_date
2019-07-01 00:00:00pages
501-508issue
4eissn
0449-3060issn
1349-9157pii
5481572journal_volume
60pub_type
杂志文章abstract::The purpose of this study is to evaluate the dose-volume metrics under different heterogeneity corrections and the factors associated with local recurrence (LR) after stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC). Eighty-three patients who underwent SBRT for pathologically proven st...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrs084
更新日期:2013-03-01 00:00:00
abstract::The paper describes the development of chemical modules simulating the prechemical and chemical stages of charged particle tracks in pure liquid water. These calculations are based on our physical track structure codes for electrons and ions (KURBUC, LEPHIST and LEAHIST) which provide the initial spatial distribution ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.47.69
更新日期:2006-03-01 00:00:00
abstract::Whole brain irradiation (WBI) has become an indispensible tool in the treatment of head and neck cancer, and it has greatly improved patient survival rate and total survival time. In addition, prophylactic cranial irradiation (PCI) has dramatically decreased the incidence of brain metastatic carcinoma. However, WBI ma...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrx041
更新日期:2017-11-01 00:00:00
abstract::The aim of the study was to investigate the various effects of high linear energy transfer (LET) carbon ion (12C6+) and low LET X-ray radiation on MDA-MB-231 and MCF-7 human breast cancer cells and to explore the underlying mechanisms of radiation sensitivity. Cell proliferation, cell colony formation, cell cycle dist...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa017
更新日期:2020-05-22 00:00:00
abstract::Six Japanese patients in Hokkaido area were diagnosed as xeroderma pigmentosum (XP) at two University Hospital; one patient, a 29 years old female (XP2AS) at Asahikawa Medical College, and five patients, namely, a 53 years old male (XP1SA), a 45 years old female (XP2SA), a 46 years old female (XP3SA), a 47 years old m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.168
更新日期:1994-09-01 00:00:00
abstract::We examined the effect of an extremely low-frequency magnetic field (ELFMF) at 5, 50 and 400 mT on DNA strand breaks in human glioma MO54 cells. A DNA damage analysis was performed using the method of alkaline comet assay. The cells were exposed to X-rays alone (5 Gy), ELFMF alone, or X-rays followed by ELFMF at 4 deg...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.41.293
更新日期:2000-09-01 00:00:00
abstract::Tritium precipitations in European cities and in Osaka, Japan were analyzed before and after the Chernobyl nuclear plant accident by the time series analysis code Census IIX11 developed by US Department of Commerce Bureau of the Census. Results of this analysis showed no significant tritium precipitation was produced ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.32.267
更新日期:1991-09-01 00:00:00
abstract::In this review, we would like to introduce a unique approach for the estimation of radioadaptation. Recently, we proposed a new methodology for evaluating the repair efficiency of DNA double-strand breaks (DSB) using a model system. The model system can trace the fate of a single DSB, which is introduced within intron...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.09050
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The aim of this study is to evaluate the cost-effectiveness of proton beam therapy with cochlear dose reduction compared with conventional X-ray radiotherapy for medulloblastoma in childhood. METHODS:We developed a Markov model to describe health states of 6-year-old children with medulloblastoma after trea...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt112
更新日期:2014-03-01 00:00:00
abstract::Alzheimer's disease (AD) is the most common progressive and irreversible neurodegenerative disease and it is caused by neuronal death in the brain. Recent studies have shown that non-ionizing radiofrequency (RF) radiation has some beneficial cognitive effects in animal models of AD. In this study, we examined the effe...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw040
更新日期:2016-11-01 00:00:00
abstract::The fertility span between the first and the last estrus was compared among female Chinese hamsters exposed to 1 Gy X-rays on neonatal day 0, 2, 4, 6, 8, 10 and 14. The fertility span changed dramatically according to the age at the time of irradiation. The females irradiated on day 4, 6 and 8 showed a definite delay ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.30.185
更新日期:1989-06-01 00:00:00
abstract::The effect of gamma-irradiation on a major nutritional function of the yolk sac (the uptake and digestion of macromolecular materials) was studied in rat visceral yolk sacs cultured in vitro being used 125I-labeled bovine serum albumin (RISA) as the tracer protein. The uptake of RISA (per g wet weight) by rat yolk sac...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.34.171
更新日期:1993-06-01 00:00:00
abstract::In this study, a mechanism in which low-dose hyper-radiosensitivity (HRS) is permanently removed, induced by low-dose-rate (LDR) (0.2-0.3 Gy/h for 1 h) but not by high-dose-rate priming (0.3 Gy at 40 Gy/h) was investigated. One HRS-negative cell line (NHIK 3025) and two HRS-positive cell lines (T-47D, T98G) were used....
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrt061
更新日期:2013-11-01 00:00:00
abstract::Gated radiation therapy is a promising method for improving the dose conformality of treatments to moving targets and reducing the total volume of irradiated tissue. Target motion is of particular concern in proton beam radiotherapy, due to the finite range of proton dose deposition in tissue. Gating allows one to red...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.48.a55
更新日期:2007-01-01 00:00:00
abstract::While recent advances in elucidating the enzyme/substrate relationship of phosphorylation cascades have demonstrated several distinct pathways in membrane-cytoplasm signaling, the molecular dissection of p53 and the products of other proto-oncogenes have greatly promoted the studies of nuclear signaling and expanded t...
journal_title:Journal of radiation research
pub_type: 杂志文章,评审
doi:10.1269/jrr.38.179
更新日期:1997-09-01 00:00:00
abstract::We examined dose-dependent or dose rate-dependent changes of superoxide dismutase (SOD) activity using a new large-scale facility for exposing small animals to radon. Mice were exposed to radon at a concentration of 250, 500, 1000, 2000, or 4000 Bq/m(3) for 0.5, 1, 2, 4, or 8 days. When mice were exposed to radon at 2...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10072
更新日期:2011-01-01 00:00:00
abstract::Radiation-induced rescue effect (RIRE) in cells refers to the phenomenon where irradiated cells (IRCs) receive help from feedback signals produced by partnered bystander unirradiated cells (UIRCs) or from the conditioned medium (CM) that has previously conditioned the UIRCs. In the present work, we explored the role o...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa023
更新日期:2020-05-22 00:00:00
abstract::Although salvage external-beam radiation therapy (EBRT) is an attractive treatment option for pelvic lymph nodal recurrence (PeNR) in patients with prostate cancer (PCa), limited data are available regarding its long-term efficacy. This study examined the long-term clinical outcomes of patients who underwent salvage p...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rraa044
更新日期:2020-07-06 00:00:00
abstract::This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.38.45
更新日期:1997-03-01 00:00:00
abstract::The aim of this research was to provide data from a single-center study of the treatment of synchronous hypopharyngeal cancer (HPC) and esophageal cancer (EC) with different treatment modalities. A total of 61 patients with synchronous HPC and EC were included in this study. Patients were treated with radiotherapy/che...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrz042
更新日期:2019-10-23 00:00:00
abstract::When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic m...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.43.s209
更新日期:2002-12-01 00:00:00
abstract::Synchrotron-radiation circular-dichroism spectroscopy was used to reveal that the DNA damage response induces a decrement of α-helix and an increment of β-strand contents of histone H3-H4 extracted from X-ray-irradiated human HeLa cells. The trend of the structural alteration was qualitatively opposite to that of our ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrw086
更新日期:2017-01-01 00:00:00
abstract::Our purpose was to develop recommendations for contouring the computed tomography (CT)-based high-risk clinical target volume (CTVHR) for 3D image-guided brachytherapy (3D-IGBT) for cervical cancer. A 15-member Japanese Radiation Oncology Study Group (JROSG) committee with expertise in gynecological radiation oncology...
journal_title:Journal of radiation research
pub_type: 杂志文章,多中心研究
doi:10.1093/jrr/rrw109
更新日期:2017-05-01 00:00:00
abstract::The purpose of this study was to analyze the clinical outcomes of simultaneous modulated accelerated radiotherapy (SMART) in patients with nasopharyngeal carcinoma (NPC). A total of 97 patients who underwent SMART for NPC between August 2005 and November 2011 were evaluated. The prescribed dose was 69.9 Gy/30 fraction...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rru012
更新日期:2014-07-01 00:00:00
abstract::The pulse radiolysis technique has been employed to determine the initiation and propagation rates of different transient species involved in the polymerization of N-isopropylacrylamide (NIPA) in aqueous solutions. Polymerization by anionic mechanism has been observed to be faster than by the free-radical mechanism. T...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.44.335
更新日期:2003-12-01 00:00:00
abstract::Low doses (2.5-15 cGy) of X-irradiation two months prior to a second exposure to a sublethal dose enhanced the survival rate in mice. Optimal and significant increase was observed with 5-10 cGy. Endogenous spleen colony counts (endo-CFUs) after 7 Gy increased by a factor of about 1.7 in mice pre-irradiated with 5-10 c...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.31.256
更新日期:1990-09-01 00:00:00
abstract::Single-photon emission computed tomography/computed tomography (SPECT/CT) demonstrates the precise location of the sentinel lymph nodes (SLNs) in patients with breast cancer. We evaluated the relationship between SLNs and postoperative tangential fields by using SPECT/CT images. Subjects included 72 patients with earl...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1093/jrr/rrv035
更新日期:2015-09-01 00:00:00
abstract::In case of an accidental overexposure to ionizing radiation where the dose received by the victim is over 5 Gy, the conventional biological indicator of dose, the dicentric assay, does not provide an accurate enough dose measurement. A more appropriate technique is to measure ring chromosomes in stimulated lymphocytes...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.0625
更新日期:2007-01-01 00:00:00
abstract::The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal hu...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.10116
更新日期:2011-01-01 00:00:00
abstract::As a part of technical improvements of chromosome aberration analysis on human peripheral lymphocytes for biological radiation dosimetry, we examined the optimal conditions for the use of colcemid in chromosome preparation in order to obtain enough number of cells at metaphase in the first cell division. When treated ...
journal_title:Journal of radiation research
pub_type: 杂志文章
doi:10.1269/jrr.35.41
更新日期:1994-03-01 00:00:00