Abstract：
:This study evaluated synthetic trehalose dicorynomycolate (S-TDCM), an immunomodulator, for its survival enhancing capacity and behavioral toxicity in B6D2F1 female mice. In survival experiments, mice were administered S-TDCM (25-400 micrograms/mouse i.p.) 20-24 hr before 5.6 Gy mixed-field fission-neutron irradiation (n) and gamma-photon irradiation. The 30-day survival rates for mice treated with 100-400 micrograms/mouse S-TDCM were significantly enhanced compared to controls. Toxicity of S-TDCM was measured in nonirradiated mice by locomotor activity, food intake, water consumption, and alterations in body weight. A dose-dependent decrease was noted in all behavioral measures in mice treated with S-TDCM. Doses of 100 and 200 micrograms/mouse S-TDCM significantly reduced motor activity beginning 12 hr postinjection with recovery by 24 hr. A dose of 400 micrograms/mouse significantly decreased activity within the first 4 hr after administration and returned to control levels by 32 hr following injection. Food and water intake were significantly depressed at doses of 200 and 400 micrograms/mouse on the day following drug administration, and were recovered in 24 hr. Body weight was significantly decreased in the 200 micrograms/mouse group for 2 days and in the 400 micrograms/mouse group for 4 days following injection. A dose of 100 micrograms/mouse effectively enhanced survival after fission-neutron irradiation with no adverse effect on food consumption, water intake, or body weight and a minimal, short-term effect on locomotor activity.
journal_name
J Radiat Resjournal_title
Journal of radiation researchauthors
Landauer MR,McChesney DG,Ledney GDdoi
10.1269/jrr.38.45subject
Has Abstractpub_date
1997-03-01 00:00:00pages
45-54issue
1eissn
0449-3060issn
1349-9157journal_volume
38pub_type
杂志文章abstract：:There is an urgent need to develop non-toxic radioprotectors. We tested the efficacy of a 3-drug combination (3-DC) of iloprost, misoprostol, and 3D-MPL (3-deacylated monophosphoryl lipid A) and the effects of postirradiation clinical support with high doses of antibiotics and blood transfusion. Canines were given 3-D...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.43.361
更新日期：2002-12-01 00:00:00
abstract：:The prognosis and treatment of thyroid cancer depends on the type and stage of the disease. Radiosensitivity differs among cancer cells owing to their varying capacity for repair after irradiation. Radioactive iodine can be used to destroy thyroid cancer cells. However, patient prognosis and improvement after irradiat...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rry097
更新日期：2019-03-01 00:00:00
abstract：:Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and are indispensable for antibacterial and antiviral immunity. Our previous report showed that ionizing radiation increases the cell surface expressions of TLR2 and TLR4 and enhances their responses to a...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrx011
更新日期：2017-09-01 00:00:00
abstract：:Efficacy of different schedules of HDR brachytherapy in concurrent chemoradiotherapy was evaluated. The study compared the effectiveness of the two HDR brachytherapy schedules which have the same Biological Effective Dose (BED) in locally advanced cervical carcinoma that was treated with concurrent chemoradiotherapy. ...
journal_title：Journal of radiation research
pub_type： 杂志文章,随机对照试验
doi：10.1269/jrr.11038
更新日期：2012-01-01 00:00:00
abstract：:This study was conducted in order to evaluate the cytotoxicity of high linear-energy-transfer (LET) ionizing radiation (IR) on glioblastoma cells and fibroblasts using different modes of cell inactivation assays. Two human glioblastoma cell lines with or without p53-mutation, and fibroblasts were used as materials. Ga...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.06081
更新日期：2007-07-01 00:00:00
abstract：:To investigate the importance of gender and aging on the individual radiosensitivity of lineage-committed myeloid hematopoietic stem/progenitor cells (HSPCs) detected in mononuclear cells (MNCs) of steady-state human peripheral blood (PB), the clonogenic survival of HPCs, including colony-forming unit-granulocyte macr...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10142
更新日期：2011-01-01 00:00:00
abstract：:Reactive oxygen species continuously oxidize DNA bases and threaten the genetic integrity. Thymine glycol (TG), one of the representative oxidized products, is repaired mainly by base excision repair (BER). In Escherichia coli, endonuclease III (Nth) and endonuclease VIII (Nei) are known to actively remove TG from DNA...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.07100
更新日期：2008-05-01 00:00:00
abstract：:Investigating the biological effects of high-LET heavy-ion irradiation at low fluence is important to evaluate the risk of radiation in space. It is especially necessary to detect radiation damage induced by a precise number of heavy ions in individual cells. We thus compared the number of ions traversing a cell and t...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.43.s153
更新日期：2002-12-01 00:00:00
abstract：:Thermionic emission (TE)-type X-ray generators have been exclusively used in medicine, but there are many difficulties in making these X-ray sources compact. A field emission (FE)-type X-ray generator using carbon nanotubes is a newly-developed compact system that can be as small as several cm in length. Considering t...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.06071
更新日期：2007-03-01 00:00:00
abstract：:In hypofractionated stereotactic radiotherapy (SRT), high doses per fraction are usually used and the dose delivery pattern is different from that of conventional radiation. The daily dose is usually given intermittently over a longer time compared with conventional radiotherapy. During prolonged radiation delivery, s...
journal_title：Journal of radiation research
pub_type： 杂志文章,评审
doi：10.1093/jrr/rrw015
更新日期：2016-08-01 00:00:00
abstract：:The International Space Environment Service (ISES) is an international organization for space weather forecasts and belongs to the International Union of Radio Science (URSI). There are eleven ISES forecast centers in the world, and Communications Research Laboratory (CRL) runs the Japanese one. We make forecasts on t...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.43.s53
更新日期：2002-12-01 00:00:00
abstract：:The aims of present study were to evaluate the efficacy of combining sunitinib with ionizing radiation (IR) on endothelial cells in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) were exposed to IR with or without sunitinib pretreatment. Apoptosis assay and cell cycle distribution were analyzed by ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10013
更新日期：2011-01-01 00:00:00
abstract：:A number of agents are now available for use in protecting against ionizing radiation. These radiation-protective agents, however, have many adverse effects. Efforts have been made to develop new radiation-protective agents for medical application. Here, we investigated whether a compound, polyethylenimine (PEI), whic...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrs098
更新日期：2013-03-01 00:00:00
abstract：:Male C3H/HeN mice were exposed to 252Cf radiation and mated with unirradiated C57BL/6N females. F1 mice were analyzed for germline mutation at the paternally derived C3H/HeN allele of a hypervariable minisatellite locus, Ms6hm. This locus exhibited a high frequency of length change mutation spontaneously, and the muta...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.37.217
更新日期：1996-09-01 00:00:00
abstract：:Fukushima residents' negative views on the safety of water and air environments have been a concern since the Fukushima Dai-ichi Nuclear power plant (FDNPP) accident. The objective of this study was to clarify the factors determining these negative views and their association with radiation risk perception using the o...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrx096
更新日期：2018-04-01 00:00:00
abstract：:Hyper-radiosensitivity (HRS) is a well-known bioresponse under low-dose or low-dose-rate exposures. Although disorder of the DNA repair function, non-targeted effects and accumulation of cells in G2 have been experimentally observed, the mechanism for inducing HRS by long-term irradiation is still unclear. On the basi...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrw110
更新日期：2017-05-01 00:00:00
abstract：:The aim of this study is to evaluate the potential radioprotective effects of N-acetylcysteine (NAC) against genotoxicity and cytotoxicity. The effect of WR-2721, as a representative of clinically used radioprotector, was compared with that of NAC, using the chromosomal aberration (CA) and micronucleus (MN) test syste...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.08066
更新日期：2009-01-01 00:00:00
abstract：:The estimation of the dose and the irradiated fraction of the body is important information in the primary medical response in case of a radiological accident. The PCC-R assay has been developed for high-dose estimations, but little attention has been given to its applicability for partial-body irradiations. In the pr...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrt032
更新日期：2013-09-01 00:00:00
abstract：:In this report we update our long-term follow-up results of the prospective study whose aim was to evaluate the efficacy of high-dose-rate (HDR) brachytherapy in combination with external-beam radiotherapy (EBRT) in the treatment of medically inoperable endometrial cancer. Between 1995 and 1998, 29 patients with stage...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.10080
更新日期：2010-01-01 00:00:00
abstract：:To determine the possible effect of hypergravity to modify the signal transduction of ionizing radiation, we analyzed the accumulation of p53 and the expression of p53-dependent genes, Waf-1 and Bax, using the western blot analysis. Hypergravity (20 x g) induced the accumulation of p53 in the human glioblastoma cell l...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.43.s261
更新日期：2002-12-01 00:00:00
abstract：:Halobacterium salinarium, a member of the extremely halophilic archaebacteria, contains a C50-carotenoid namely bacterioruberin. We have previously reported the high resistance of this organism against the lethal actions of DNA-damaging agents including ionizing radiation and ultraviolet light (UV). In this study, we ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.39.251
更新日期：1998-12-01 00:00:00
abstract：:Respiratory motion management is a huge challenge in radiation therapy. Respiratory motion induces temporal anatomic changes that distort the tumor volume and its position. In this study, a markerless tumor-tracking algorithm was investigated by performing phase recognition during stereotactic body radiation therapy (...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rry085
更新日期：2019-01-01 00:00:00
abstract：:The objective of the present study was to estimate cancer risk associated with the low-level radiation exposure of an average annual effective dose of 6.4 mSv (including internal exposure) in the high background-radiation areas (HBRA) in Yangjiang, China. The mortality survey consisted of two steps, i.e., the follow-u...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.41.s31
更新日期：2000-10-01 00:00:00
abstract：:We investigated the sensitizing effect of the 2-nitroimidazole analogue doranidazole, a new hypoxic radiosensitizer, on radiation-induced apoptosis in L5178Y cells. Apoptosis was assessed by checking DNA ladder formation, the presence of sub-G1 peaks in flow cytometry, and chromatin condensation. A radiosensitizing ef...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.43.161
更新日期：2002-06-01 00:00:00
abstract：:The radioprotective effect of chitosan was studied in mice following whole-body X-ray irradiation. C3H/He mice were exposed to 7 Gy, and their survival rates were examined. The survival rates of chitosan-diet mice were about 20% higher than those of mice on a standard diet, and the rates dropped sharply to a plateau a...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.44.53
更新日期：2003-03-01 00:00:00
abstract：:The purpose of this study was to evaluate interfractional changes of the minimum dose delivered to 90% of the high-risk clinical target volume (HR-CTV D90) and D2cc of the bladder and rectum during brachytherapy for uterine cervical cancer patients. A total of 52 patients received external beam radiotherapy and high-d...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrt073
更新日期：2013-11-01 00:00:00
abstract：:In intensity-modulated radiation therapy (IMRT) and stereotactic irradiation using a linear accelerator, radiation is administered intermittently and one treatment session often requires 30 min or a longer time. The purpose of the present study was to investigate the effect of fractionation and dose per fraction on ce...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1269/jrr.46.401
更新日期：2005-12-01 00:00:00
abstract：:This project aimed to set up a Beagle dog model of radiation-induced lung injury in order to supply fresh lung tissue samples in the different injury phases for gene and protein research. Three dogs received 18 Gy X-ray irradiation in one fraction, another three dogs received 8 Gy in each of three fractions at weekly ...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrw053
更新日期：2016-09-01 00:00:00
abstract：:In the last few years, hospital-based facilities for carbon-ion radiotherapy are being constructed and proposed in Europe and Asia. During the next few years, several new facilities will be opened for carbon-ion radiotherapy in the world. These facilities in operation or under construction are categorized in two types...
journal_title：Journal of radiation research
pub_type： 杂志文章,评审
doi：10.1269/jrr.10028
更新日期：2010-01-01 00:00:00
abstract：:This study proposes a quality assurance (QA) method incorporating radiobiological factors based on the QUANTEC-determined tumor control probability and the normal tissue complication probability (NTCP) of head-and-neck intensity-modulated radiation therapy (HN-IMRT). Per-beam measurements were conducted for 20 cases u...
journal_title：Journal of radiation research
pub_type： 杂志文章
doi：10.1093/jrr/rrx017
更新日期：2017-09-01 00:00:00
